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Functional Diversity of SIRT7 Across Cellular Compartments: Insights and Perspectives

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Abstract

Posttranslational modifications (PTMs) play important roles in the regulation of protein function. Acetylation and deacetylation are among the most important PTMs. SIRT7 is a relatively understudied member of the sirtuin family, but recent studies have revealed that it plays a regulatory role in a variety of cellular activities, such as genome stabilization and repair, gene translation, ribosome production and other important processes. Here, we provide a list of the functions and mechanisms of SIRT7 in various organelles and show the important role of SIRT7 in maintaining normal cell function.

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Funding

Natural Science Foundation of Zhejiang Province, LGD22H160007.

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Authors and Affiliations

  1. Zhejiang University School of Medicine, Hangzhou, China

    Songtao Wu

  2. Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China

    Shengnan Jia

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  1. Songtao Wu
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  2. Shengnan Jia
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S.W. wrote and edited the manuscript, and S.J. edited and approved the manuscript.

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Correspondence to Songtao Wu or Shengnan Jia.

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Wu, S., Jia, S. Functional Diversity of SIRT7 Across Cellular Compartments: Insights and Perspectives. Cell Biochem Biophys 81, 409–419 (2023). https://doi.org/10.1007/s12013-023-01162-z

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