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FGF Exhibits an Important Biological Role on Regulating Cell Proliferation of Breast Cancer When it Transports Into The Cell Nuclei

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Abstract

The endocrine system is closely related to the development of the breast cancer. Many studies have shown that FGF1 (Fibroblast growth factor-1) is involved the occurrence and development of the breast cancer. But up to now, the cellular behavior and characteristics of FGF1 in breast cancer have not been fully revealed. In the current study, breast cancer cell was used as an in vitro cell model to investigate FGF’s cell property. The results showed that FGF1 internalized into cells in a time-dependent manner. Further study indicated that both clathrin-mediated and caveolin-mediated endocytic pathway are involved in the internalization of FGF/FGFR (Fibroblast growth factor receptor), and both clathrin-mediated endocytosis and caveolin-mediated endocytosis are involved in the process of FGF1’s nuclear localization. Further study showed that Rab5 also plays an important role in the process of nuclear localization of FGF-1. In addition, we found that FGF1 and FGFR transported to the cell nuclei of breast cancer. Further experimental results indicated that the nuclear-localized FGF1 and/or FGFR is closely associated to cell proliferation of breast cancer cell. Taken together, the current work lays the foundation for exploring the relationship between nuclear-localized FGF1/FGFR and the occurrence and development of breast cancer.

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All data included in this study are available upon request by contact with the corresponding author.

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Acknowledgements

The author thanks Dr. Y.W. for the necessary information.

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Authors and Affiliations

  1. Tianjin First Central Hospital No. 24 Fukang Road, Nankai District, Tianjin, People’s Republic of China

    Yu Gao, Yiwei Wang, Juan Yu & Rende Guo

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  1. Yu Gao
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  2. Yiwei Wang
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  3. Juan Yu
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  4. Rende Guo
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Contributions

Y.G. and R.-de.G., performed the experiments; Y.G. drafted the paper. J.Y. and Y.W. edited the paper. Y.G. and R.-de.G. conceived of the study, and participated in its design and coordination.

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Correspondence to Yu Gao.

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Gao, Y., Wang, Y., Yu, J. et al. FGF Exhibits an Important Biological Role on Regulating Cell Proliferation of Breast Cancer When it Transports Into The Cell Nuclei. Cell Biochem Biophys 80, 311–320 (2022). https://doi.org/10.1007/s12013-021-01044-2

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  • DOI: https://doi.org/10.1007/s12013-021-01044-2

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