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Suppression of lncRNA HOXA11-AS/miR-124 Axis Inhibits Glioma Progression

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Abstract

Our aim was to clarify the regulations of lncRNA HOXA11-AS (HOXA11-AS) played on the progression of glioma as well as to investigate the mechanisms by which HOXA11-AS modulated development of glioma. This study confirmed the regulations of miR-124 and HOXA11-AS on the progression of glioma. Here, HOXA11-AS was overexpressed and miR-124 was underexpressed in glioma. Expression of miR-124 was negatively related to that of HOXA11-AS. Silencing of HOXA11-AS suppressed cell proliferation, invasion, and promoted apoptosis in glioma cells in vitro. Moreover, inhibition of HOXA11-AS expression repressed glioma xenograft tumor growth. Expression of miR-124 was repressed by HOXA11-AS functioning as sponge. In addition, miR-124 knockdown partially abolished the inhibitory roles of HOXA11-AS downregulation in glioma cells. Conclusively, this study suggested that silencing of HOXA11-AS restrained proliferation, invasion, induced apoptosis of glioma cells, and repressed xenograft growth via modulating miR-124 expression and thus inhibited glioma progression.

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Authors and Affiliations

  1. Department of Breast Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

    Yishan He

  2. Department of Thyroid Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

    Xinguang Qiu

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  1. Yishan He
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  2. Xinguang Qiu
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Correspondence to Xinguang Qiu.

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He, Y., Qiu, X. Suppression of lncRNA HOXA11-AS/miR-124 Axis Inhibits Glioma Progression. Cell Biochem Biophys 79, 815–822 (2021). https://doi.org/10.1007/s12013-021-01007-7

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