Abstract
Women constitute more than 50% out of millions of individuals infected with HIV-1, the major causative agent of acquired immune deficiency syndrome. About 40% of HIV-1 infections have been reported to initiate in the female reproductive tract. However, the mechanisms through which these infections are spread are poorly understood; hence, there is now a major concern in women who use long acting injectable hormonal contraceptives, particularly Depo-Provera and an increase of HIV-1 risk acquisition. Based on literature, Depo-Provera has an affinity for both the glucocorticoid receptor and the progesterone receptor in the female reproductive tract. Therefore, investigating HIV-1 pathogenesis in the female reproductive tract via the glucocorticoid receptor and the progesterone receptor mechanisms in response to the effect of Depo-Provera is of great importance.
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Moonsamy, S., Bhakat, S., & Soliman, M. E. S. (2014). Dynamic features of apo and bound HIV-Nef protein reveal the anti-HIV dimerization inhibition mechanism. Journal of Receptors and Signal Transduction, 9893, 1–11.
Sharp, P. M., & Hahn, B. H. (2011). Origins of HIV and the AIDS pandemic. Cold Spring Harbor Perspectives in Medicine, 1, 1–22.
Herrera-Carrillo, E., & Berkhout, B. (2015). Bone marrow gene therapy for HIV/AIDS. Viruses, 7, 3910–3936.
Tomasicchio, M., Avenant, C., Du Toit, A., Ray, R. M., & Hapgood, J. P. (2013). The progestin-only contraceptive medroxyprogesterone acetate, but not norethisterone acetate, enhances HIV-1 Vpr-mediated apoptosis in human CD4+T cells through the glucocorticoid receptor. PLoS ONE, 8(5), 1–15.
Palmisano, L., & Vella, S. (2011). A brief history of antiretroviral therapy of HIV infection: Success and challenges. Annali dell’Istituto Superiore di Sanità, 47(1), 44–48.
Polis, C. B., Phillips, S. J., Curtis, K. M., Westreich, D. J., Steyn, P. S., & Raymond, E., et al. (2014). Hormonal contraceptive methods and risk of HIV acquisition in women: A systematic review of epidemiological evidence. Contraception, 90, 360–390.
Ralph, L. J., McCoy, S. I., Shiu, K., & Padian, N. S. (2015). Hormonal contraceptive use and women’s risk of HIV acquisition: A meta-analysis of observational studies. The Lancet Infectious Diseases, 3099(14), 1–11.
Schindler, A. E., Campagnoli, C., Druckmann, R., Huber, J., Pasqualini, J. R., & Schweppe, K. W., et al. (2003). Classification and pharmacology of progestins. Maturitas, 46, 7–16.
National Institute of Allergy and Infectious Diseases (NIAID) (2005). The HIV life cycle. http://aidsinfo.nih.gov. Accessed 21 June 2016.
Engelman, A., & Cherepanov, P. (2013). The structural biology of HIV-1: Mechanistic and therapeutic insights. Nature Reviews Microbiology, 10(4), 279–290.
Does, A. (2007). HIV and AIDS. Available online at the following website: http://www.learner.org/courses/biology/support/textbook_full.pdf. Accessed 2 June 2017.
Mostad, S. B., Overbaugh, J., DeVange, D. M., Welch, M. J., Chohan, B., & Mandaliya, K., et al. (1997). Hormonal contraception, vitamin a deficiency, and other risk factors for shedding of HIV-1 infected cells from the cervix and vagina. Lancet, 350, 922–927.
Mmbaga, E. J. (2013). HIV prevalence and associated risk factors: Analysis of change over time in mainland Tanzania. DHS working papers 85, 1–38.
Bruland, T. (2003). Studies of early retrovi rus-host interactions. Norwegian University of Science and Technology. Det medisinske fakullet.
Nguyen, P. V., Kafka, J. K., Ferreira, V. H., Roth, K., & Kaushic, C. (2014). Innate and adaptive immune responses in male and female reproductive tracts in homeostasis and following HIV infection. Cellular & Molecular Immunology, 11, 410–427.
Hills-Nieminen, C., Foisy, M., & Tseng, A. (2015). Interaction between antiretrovirals (ARVs) and hormonal contraceptives. http://www.hivclinic.ca. Accessed 21 June 2016.
UNAIDS (2013). Access to antiretroviral therapy in Africa: Status report on progress towards the 2015 targets. http://www.unaids.org/sites/default/files/media_asset/20131219_AccessARTAfricaStatusReportProgresstowards2015Targets. Accessed 21 June 2016.
Lundgren, J. D., Babiker, A. G., Gordin, F., Emery, S., Grund, B., & Sharma, S., et al. (2015). Initiation of antiretroviral therapy in early asympyomatic HIV infection. The New England Journal of Medicine, 373(9), 795–807.
Hicks, C., & Gulick, R. M. (2009). Raltegravir: The first HIV type 1 integrase inhibitor. Clinical Infectious Diseases, 48, 931–939.
Watts, D. H., Park, J. G., Cohn, S. E., Yu, S., Hitti, J., & Stek, A., et al. (2008). Safety and tolerability of depot medroxyprogesterone acetate among HIV-infected women on antiretroviral therapy: ACTG A5093. Contraception, 77, 84–90.
Bonny, A. E., Ziegler, J., Harvey, R., Debanne, S. M., Sesic, M., & Cromer, B. A. (2006). Weight gain in obese and nonobese adolescent girls initiating depot medroxyprogesterone, oral contraceptive pills, or no hormonal contraceptive method. Archives of Pediatrics & Adolescent Medicine, 160, 40–45.
McKay, L. I., & Cidlowski, J. A. (1999). Molecular control of immune/inflammatory responses: Interactions between nuclear factor-kB and steroid receptor-signaling pathways. Endocrine Reviews, 20(4), 435–459.
Bledsoe, R. K., Montana, V. G., Stanley, T. B., Delves, C. J., Apolito, C. J., & McKee, D. D., et al. (2002). Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell, 110, 93–105.
Africander, D., Verhoog, N., & Hapgood, J. P. (2011). Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception. Steroids, 76, 636–652.
Aranda, A., & Pascual, A. (2001). Nuclear hormone receptors and gene expression. Physiological Reviews, 81, 1269–1304.
De Bosscher, K., Van Craenenbroeck, K., Meijer, O. C., & Haegeman, G. (2008). Selective transrepression versus transactivation mechanisms by glucocorticoid receptor modulators in stress and immune systems. European Journal of Pharmacology, 583, 290–302.
Sedwick, C. (2014). Wanted: A new model for glucocorticoid receptor transactivation and transrepression. PLoS Biology, 12(3), 1–2.
Zhong, H., Voll, R. E., & Ghosh, S. (1998). Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Molecular Cell, 1, 661–671.
Oeckinghaus, A., & Ghosh, S. (2009). The NF-kappaB family of transcription factors and its regulation. Cold Spring Harbor Perspectives in Biology, 1, 1–14.
Barnes, P. J., Adcock, I. M., & Ito, K. (2005). Histone acetylation and deacetylation: Importance in inflammatory lung diseases. The European Respiratory Journal, 25(3), 552–563.
Louw-du Toit, R., Hapgood, J. P., & Africander, D. (2014). Medroxyprogesterone acetate differentially regulates interleukin (IL)-12 and IL-10 in a human ectocervical epithelial cell line in a glucocorticoid receptor (GR)-dependent manner. The Journal of Biological Chemistry, 289, 31136–31149.
Felzien, L. K., Woffendin, C., Hottiger, M. O., Subbramanian, R. A., Cohen, E. A., & Nabel, G. J. (1998). HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator. Proceedings of the National Academy of Sciences USA, 95, 5281–5286.
Guenzel, C., Herate, C., & Benichou, S. (2014). HIV-1 Vpr-a still “enigmatic multitasker”. Frontiers in Microbiology, 5, 1–13.
Wu, Y., Zhou, X., Barnes, C. O., Delucia, M., Cohen, A. E., Gronenborn, A. M., Ahn, J., & Calero, G. (2016). The DDB1-DCAF1-Vpr-UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction. Nature Structural & Molecular Biology, 23, 933–940.
Zahoor, M. A., Xue, G., Sato, H., Murakami, T., Takeshima, S. N., & Aida, Y. (2014). HIV-1 Vpr induces interferon-stimulated genes in human monocyte-derived macrophages. PLoS ONE, 9(8), 1–13.
Williams S. P., & Sigler P. B. (1998) Atomic structure of progesterone complexed with its receptor. Nature, 393, 392–396.
Irwin J. J., & Shoichet B. K. (2005) Zinc- A free database of commercially available compounds for Virtual Screening. Journal of Chemical Information and Modeling, 45(1), 177–182.
Trott O., & Olson A. J. (2010) AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading. Journal of Computational Chemistry, 31(2), 455–461.
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The authors would like to acknowledge the University of KwaZulu-Natal, College of Health Sciences for funding, and the Centre for High Performance Computing for computational resources.
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Takalani, F., Mhlongo, N.N., Moonsamy, S. et al. Review on the Biological Mechanisms Associated with Depo-Provera and HIV-1 Risk Acquisition in Women. Cell Biochem Biophys 76, 73–82 (2018). https://doi.org/10.1007/s12013-017-0806-5
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DOI: https://doi.org/10.1007/s12013-017-0806-5