Abstract
In this study, we report the change of semen superoxide dismutase (SOD) and acrosin activities in the male sterility patients with positive antisperm antibody (AsAb). The activity of SOD was measured by xanthine oxidase assay and sperm acrosin activity was calculated by BAEE/ADH. Our data show that compared with the normal fertility group, the semen SOD activity in AsAb-positive patients was significantly lower. Similarly, the sperm acrosin activity in AsAb-positive patients was also significantly lower. Our results suggest that the sterility resulting from positive AsAb may be related with the changes of semen SOD and sperm acrosin activities.
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Rumke, P., & Hellinga, G. (1959). Auto-antibodies against spermatozoa in sterilemen. American Journal of Pathology, 32, 357–359.
Bronson, R., Cooper, G., & Rosenfeld, D. (1981). Ability of antibody-bound human sperm to penetrate zona-free hamster ova in vitro. Fertility and Sterility, 36, 778–783.
Alexander, N. J. (1984). Antibodies to human spermatozoa impede sperm penetration of cervical mucus or hamster eggs. Fertility and Sterility, 41, 433–439.
Clarke, G. N., Hyne, R. V., du Plesis, Y., & Johnston, W. I. H. (1988). Sperm antibodies and human in vitro fertilization. Fertility and Sterility, 49, 1018–1024.
Bronson, R. A., Fusi, F., Cooper, G. W., & Phillips, D. M. (1990). Antisperm antibodies induce polyspermy by promoting adherence of human sperm to zona-free hamster eggs. Human Reproduction, 5, 690–696.
Yeh, W.-R., Acosta, A. A., Seltman, H. J., & Doncel, G. (1995). Impact of immunoglobulin isotype and sperm surface location of antisperm antibodies on fertilization in vitro in the human. Fertility and Sterility, 63, 1287–1292.
Naz, R. K. (1992). Effects of antisperm antibodies on early cleavage of fertilizedova. Biology of Reproduction, 46, 130–139.
Jones, W.R. (1976). Immunological aspects of infertility. In J. S. Scott & W. R. Jones (Eds.), Immunology of human reproduction. London: Academic Press.
Mathur, S., Baker, E. R., Williamson, H. O., Derrick, F. C., Teague, K. J., & Fudenberg, H. H. (1981). Clinical significance of sperm antibodies in infertility. Fertility and Sterility, 36, 486–495.
Haas, G. G., Kubota, K., Quebbeman, J. F., Jijon, A., Menge, A. C., & Beer, A. E. (1986). Circulating antisperm antibodies in recurrent aborting women. Fertility and Sterility, 45, 209–215.
Witkin, S. S., & Chaudhry, A. (1989). Association between recurrent spontaneous abortion sand circulating IgG antibodies to sperm tails in women. Journal of Reproductive Immunology, 15, 151–158.
Franklin, R. R., & Dukes, C. D. (1964). Antispermatozoal antibody and unexplained infertility. American Journal of Obstetrics and Gynecology, 89, 6–9.
Isojima, S., Li, T. S., & Ashitaka, Y. (1968). Immunologic analysis of sperm immobilizing factor found in sera of women with unexplained sterility. American Journal of Obstetrics and Gynecology, 101, 677–683.
Edwards, R. G. (1969). Immunologic alaspects o finfertility. Proceedings of the Royal Society of Medicine, 62, 25–26.
Ayvaliotis, B., Bronson, R., Rosenfeld, D., & Cooper, G. (1985). Conception rates in couples where autoimmunity to sperm is detected. Fertility and Sterility, 43, 739–742.
Ping, W. W. (1979). Sperm antibody activity in human fallopian tube fluid. Fertility and Sterility, 32, 681–684.
Ingerslev, H. J., & Ingerslev, M. (1980). Clinical findings in infertile women with circulating antibodies against spermatozoa. Fertility and Sterility, 33, 514–520.
Check, J. H., Katsoff, D., Bollendorf, A., & Callan, C. (1995). The effect of sera antisperm antibodies in the female partner on in vivo and in vitro pregnancy and spontaneous abortion rates. American Journal of Reproductive Immunology, 33, 131–133.
Simpson, J. L., Carson, S. A., Mills, J. L., Conley, M. R., Aarons, J., Holmes, L. B., et al. (1996). Prospective study showing that antisperm antibodies are not associated with pregnancy losses. Fertility and Sterility, 66, 36–42.
Szabo, J., Bartok, K., Kereni, T., et al. (2000). Follow-up of prostate carcinoma patients treated with total androgen blockade by repeated map-biopsy. Annales d’Urologie (L Paris) 34(4):236–239.
Shiina, H., Igawa, M., Shigeno, K., et al. (1997). Relationship of serum testosterone level with proliferating cell nuclear antigen and nm23 protein inhuman prostatic carcinoma tissue. Oncology, 54(6), 482–489.
Myers, R. B., KudIow, J. E., & GrizzIe, W. E. (1993). Expression of transforming growth factor-alpha, epidermal growth factor and the epidermal growth factor receptor in adenocarcinoma of the prostate and benign prostatic hyperplasia. Modern Pathology, 6(1), 733–737.
Dijkman, G. A., Janknegr, R. A., De Reyke, T. M., et al. (1997). Long-term efficacy and safety of Nilutamide plus castration in advanced prostate cancer, and the significance of early prostate specific antigen normalization. Journal of Urology, 158(1), 160–163.
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Zhang, H., Zhao, E., Zhang, C. et al. The Change of Semen Superoxide Dismutase and Acrosin Activity in the Sterility of Male Patients with Positive Antisperm Antibody. Cell Biochem Biophys 73, 451–453 (2015). https://doi.org/10.1007/s12013-015-0663-z
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DOI: https://doi.org/10.1007/s12013-015-0663-z