Abstract
The purpose is to observe the clinical effect of large doses of ambroxol hydrochloride in lung protection during the perioperative period of lung cancer operation. Fifty-six lung cancer patients who have undergone open-thoracic pulmonary lobectomy were divided randomly into two groups, and were given normal and large doses of ambroxol hydrochloride, respectively, during their perioperative period. Statistics based on post-operation clinical observations were analyzed in terms of ease of expectoration and expectoration properties, duration of antibiotics dependence, occurrence of lung complications, and adverse reactions related to ambroxol hydrochloride. On the third and the seventh day, the experimental group showed signs of improvement in terms of ease of expectoration and expectoration properties, compared with the controlled group. In terms of occurrence of post-operation lung complications and duration of antibiotics dependence, the experimental group also performed better. Using large doses of ambroxol hydrochloride would result in better clinical effects than using normal doses in preventing post-operation complications, and its clinical value in lung protection during lung cancer perioperative period calls for further research and promotion.
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Thanks to the Xuzhou central hospital which supported this study.
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Wang Xin and Wang Lei have contributed equally to the study and should be considered as co-first authors.
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Wang, X., Wang, L., Wang, H. et al. Perioperative Lung Protection Provided by High-Dose Ambroxol in Patients with Lung Cancer. Cell Biochem Biophys 73, 281–284 (2015). https://doi.org/10.1007/s12013-015-0590-z
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DOI: https://doi.org/10.1007/s12013-015-0590-z