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Matrix Metalloproteinase-14 Expression and Its Prognostic Value in Cervical Carcinoma

Cell Biochemistry and Biophysics volume 70, pages 729–734 (2014)Cite this article

Abstract

The objective of the study was to evaluate the expression of matrix metalloproteinase-14 (MMP-14) in cervical carcinoma and correlate its expression with clinicopathological parameters, recurrence, and survival of the patients. The expressions of MMP-14 in normal cervical mucosa and cervical carcinoma tissue were detected with immunohistochemistry. Survival analysis by the Kaplan–Meier method was performed to assess prognostic significance. The positive expression rate of MMP-14 in cervical carcinoma tissue was 81.6 %(111/136), and there was significant difference on their positive expression rates between in cervical carcinoma tissue and in normal cervical mucosa(22.4 %)(13/58)(P < 0.05);The positive expression rates of MMP-14 in patients with poor histologic differentiation, lymph node metastasis, and recurrence group were heightened. Using Kaplan–Meier analysis, a comparison of survival curves of low versus high expressions of MMP-14 revealed a highly significant difference in human cervical carcinoma tissue (P < 0.05), which suggests that overexpression of MMP-14 is associated with a worse prognosis. The MMP-14 which promotes angiogenes is associated with lymph node metastasis, vascular invasion, and poor prognosis of cervical carcinoma. The current study shows that MMP-14 may be an independent prognostic factor for cervical carcinoma patients.

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Acknowledgments

The authors are very grateful to Zhigao Xu (M.D., Department of Pathology, Zhongnan Hospital of Wuhan University) for his excellent technical support.

Conflict of interest

The authors declare no conflicts of interest.

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Affiliations

  1. Department of Pathology, The Affiliated Hospital of Hubei College of Chinese Medicine and Jingzhou Second People Hospital, Jingzhou, Hubei Province, 434000, China

    Huayi Wang & Jia Li

  2. Department of Obstetrics and Gynecology, Jingzhou Second People Hospital, 241 Jiangjin Road, Jingzhou, Hubei Province, 434000, China

    Xianhua Zhang, Shuyun Qu & Fenglian Pan

  3. Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, 430071, China

    Liming Huang

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  1. Huayi Wang
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  2. Xianhua Zhang
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  3. Liming Huang
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  4. Jia Li
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Correspondence to Fenglian Pan.

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Wang, H., Zhang, X., Huang, L. et al. Matrix Metalloproteinase-14 Expression and Its Prognostic Value in Cervical Carcinoma. Cell Biochem Biophys 70, 729–734 (2014). https://doi.org/10.1007/s12013-014-9974-8

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  • DOI: https://doi.org/10.1007/s12013-014-9974-8

Keywords

  • Cervical carcinoma
  • MMP-14
  • Prognosis
  • Survival