Cell Biochemistry and Biophysics

, Volume 70, Issue 1, pp 437–442 | Cite as

Late Remote Ischemic Preconditioning Provides Benefit to Patients Undergoing Elective Percutaneous Coronary Intervention

  • Zhi Liu
  • Yan-Ling Wang
  • Dong Xu
  • Qi Hua
  • Yan-Yan Chu
  • Xun-Ming JiEmail author
Original Paper


To assess whether late remote ischemic preconditioning (L-RIPC) is effective in myocardial protection in patients with ischemic heart disease undergoing elective percutaneous coronary intervention (PCI). L-RIPC is exerted by newly synthesized cardioprotective proteins. The cardioprotective effects of L-RIPC are more durable. 200 consecutive patients undergoing elective PCI were randomized to receive L-RIPC (induced by three 5-minute inflations of a blood pressure cuff to 200 mmHg around the upper arm, followed by 5-min intervals of reperfusion) or control (an uninflated cuff around the arm) at 18 h before PCI. Creatine phosphokinase (CK), its cardiac isoenzyme (CK-MB), troponin I (TNI), and high-sensitivity C-reactive protein (hs-CRP) levels were measured at 24 h after PCI. Adverse events’ rates at 6 months were assessed. Compared with the control group, patients in L-RIPC group were observed with significantly lower incidences in Chest pain score >1 and ECG ST deviation >1 mm (P < 0.05). The median TNI, CK, and CK-MB concentrations at 24 h were lower in the L-RIPC group (0.009 vs. 0.036 ng/mL, 123 vs. 186 IU/L, 15 vs. 27 IU/L; P < 0.05). There was no statistical difference in hs-CRP between two groups. At 6 months, the adverse events’ rate was lower in the L-RIPC group (P = 0.036). L-RIPC is effective in myocardial protection in patients undergoing elective PCI and reduces adverse events’ rate at 6 months.


Late remote ischemic preconditioning Ischemic heart disease Elective percutaneous coronary intervention Troponin I 


Conflict of interest

None of authors have a conflict of interest.


The contents are solely the responsibility of the authors and do not represent the official view of any organization.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Zhi Liu
    • 1
  • Yan-Ling Wang
    • 1
  • Dong Xu
    • 1
  • Qi Hua
    • 1
  • Yan-Yan Chu
    • 1
  • Xun-Ming Ji
    • 2
    Email author
  1. 1.Department of Cardiology, Xuanwu HospitalCapital Medical UniversityBeijingChina
  2. 2.Department of Intervention, Xuanwu HospitalCapital Medical UniversityBeijingChina

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