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A Clinical Study of Patients with Coronary Heart Disease Complicated with Hypertriglyceridemic Waist Phenotype

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Abstract

The objective of this study was to investigate the characteristics of coronary lesions in patients with coronary heart disease complicated with hypertriglyceridemic waist phenotype and determine the relation to risk factors. For this purpose, 105 patients with ≥50 % stenosis in one branch of coronary arteries as confirmed by coronary angiography were enrolled. Further, in this regard, 41 cases (i.e., case group) were complicated with hypertriglyceridemic waist phenotype, while 64 patients (i.e., control group) were not complicated with this phenotype. The data show that, as compared with control group, the patients in case group had higher coronary artery scores. The coronary lesions in case group were associated with waist triglycerides index and tumor necrosis factor (TNF)-α; partial regression coefficients were 0.774 (P < 0.001) and 0.250 (P = 0.001), respectively. Therefore, it was concluded that the patients with hypertriglyceridemic waist phenotype had a worse coronary heart disease condition, whereas waist triglycerides index and TNF-α related closely to the severity of coronary lesions.

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References

  1. Arsenault, B. J., Lachance, D., Lemieux, I., et al. (2007). Visceral adipose tissue accumulation, cardiorespiratory fitness, and features of the metabolic syndrome. Archives of Internal Medicine, 167, 1518–1525.

    Article  CAS  PubMed  Google Scholar 

  2. Arsenault, B. J., Lemieux, I., Despres, J.-P., et al. (2010). The hypertriglyceridemic waist phenotype and the risk of coronary artery disease: Results from the EPIC-Norfolk prospective population study. Canadian Medical Association Journal, 182, 1427–1432.

    Article  PubMed Central  PubMed  Google Scholar 

  3. Lemieux, I., Poirier, P., Bergeron, J., et al. (2007). Hypertriglyceridemic waist: A useful screening phenotype in preventive cardiology? Canadian Journal of Cardiology, 23(Suppl B), 23B–31B.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Sam, S., Haffner, S., Davidson, M. H., et al. (2009). Hypertriglyceridemic waist phenotype predicts increased visceral fat in subjects with type 2 diabetes. Diabetes Care, 32, 1916–1920.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. St-Pierre, J., Lemieux, I., Vohl, M. C., et al. (2002). Contribution of abdominal obesity and hypertriglyceridemia to impaired fasting glucose and coronary artery disease. American Journal of Cardiology, 90, 15–18.

    Article  CAS  PubMed  Google Scholar 

  6. Bardini, G., Dicembrini, I., Pala, L., Cresci, B., & Rotella, C. M. (2011). Hypertriglyceridemic waist phenotype and β-cell function in subjects with normal and impaired glucose tolerance. Diabetic Medicine, 28, 1229–1233.

    Article  CAS  PubMed  Google Scholar 

  7. Lemieux, I., Pascot, A., Couillard, C., et al. (2000). Hypertriglyceridemic waist: A marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men? Circulation, 102, 179–184.

    Article  CAS  PubMed  Google Scholar 

  8. Lamarche, B., Tchernof, A., Mauriège, P., et al. (1998). Fasting insulin and apolipoprotein B levels and low-density lipoprotein particle size as risk factors for ischemic heart disease. The Journal of the American Medical Association, 279, 1955–1961.

    Article  CAS  Google Scholar 

  9. Chinese Society of Cardiology. (2011). Editorial board of Chinese journal of cardiology: Chinese prevention guidelines of cardiovascular diseases. Chinese Journal of Cardiology, 39, 3–22.

    Google Scholar 

  10. Xiao-yu, L., Yan, G., Wang-yu, Y., et al. (2003). The relation of small dense low-density lipoprotein and the risk factors to stroke. Zhonghua Yixue Zazhi, 83, 1939–1941.

    Google Scholar 

  11. Fruchart, J. C., Sacks, F. M., Hermans, M. P., et al. (2008). The residual risk reduction initiative: A call to action to reduce residual vascular risk in dyslipidemic patients. A condensed position paper by the residual risk reduction initiative (R3j). Diabetes and Vascular Diseases Research, 5, 319–335.

    Article  Google Scholar 

  12. Taskinen, M. R., Adiels, M., Westerbacka, J., et al. (2011). Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects. Arteriosclerosis, Thrombosis, and Vascular Biology, 31, 1946–1948.

    Article  Google Scholar 

  13. Atar, I. A., Atar, I., Aydınalp, A., et al. (2011). Is there any relationship between coronary artery disease and postprandial triglyceride levels? The Anatolian Journal of Cardiology, 11, 201–206.

    Google Scholar 

  14. Nordestgaard, B. G., Benn, M., Schnohr, P., et al. (2007). Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. The Journal of the American Medical Association, 298, 299–308.

    Article  CAS  Google Scholar 

  15. Després, J. P., & Lemieux, I. (2006). Abdominal obesity and metabolic syndrome. Nature, 444, 881–887.

    Article  PubMed  Google Scholar 

  16. Tanko, L. B., Bagger, Y. Z., Qin, G., et al. (2005). Enlarged waist combined with elevated triglycerides is a strong predictor of accelerated atherogenesis and related cardiovascular mortality in postmenopausal women. Circulation, 111, 1883–1890.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

The authors thank Kunming Medical Colleges and Yunnan Provincial Science and Technology Department for financial support (Project Code: 2007C0021R).

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Authors and Affiliations

  1. Department of Cardiology, The 2nd Affiliated Hospital with Kunming Medical University, Kunming, 650101, China

    Rui-feng Yang, Zhi Lin, Xiao-yong Liu & Ge Zhang

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  1. Rui-feng Yang
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  2. Zhi Lin
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  3. Xiao-yong Liu
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  4. Ge Zhang
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Correspondence to Ge Zhang.

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Yang, Rf., Lin, Z., Liu, Xy. et al. A Clinical Study of Patients with Coronary Heart Disease Complicated with Hypertriglyceridemic Waist Phenotype. Cell Biochem Biophys 70, 289–293 (2014). https://doi.org/10.1007/s12013-014-9906-7

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  • DOI: https://doi.org/10.1007/s12013-014-9906-7

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