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Adenosylmethionine Decarboxylase 1 (AMD1)-Mediated mRNA Processing and Cell Adhesion Activated & Inhibited Transition Mechanisms by Different Comparisons Between Chimpanzee and Human Left Hemisphere

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Abstract

To understand adenosylmethionine decarboxylase 1 (AMD1)-mediated mRNA processing and cell adhesion activated & inhibited transition mechanisms between chimpanzee and human left hemisphere, AMD1-activated different complete (all no positive correlation, Pearson correlation coefficient < 0.25) and uncomplete (partly no positive correlation except AMD1, Pearson < 0.25) networks were identified in higher human compared with lower chimpanzee left hemisphere from the corresponding AMD1-stimulated (Pearson ≥ 0.25) or inhibited (Pearson ≤ −0.25) overlapping molecules of Pearson and GRNInfer, respectively. This result was verified by the corresponding scatter matrix. As visualized by GO, KEGG, GenMAPP, BioCarta, and disease database integration, we proposed mainly that AMD1-stimulated different complete network was involved in AMD1 activation with cytoplasm ubiquitin specific peptidase (tRNA-guanine transglycosylase) to nucleus paired box-induced mRNA processing, whereas the corresponding inhibited network participated in AMD1 repression with cytoplasm protocadherin gamma and adaptor-related protein complex 3-induced cell adhesion in lower chimpanzee left hemisphere. However, AMD1-stimulated network contained AMD1 activation with plakophilin and phosphodiesterase to SH3 binding glutamic acid-rich protein to dynein and zinc finger-induced cell adhesion, whereas the corresponding inhibited different complete network included AMD1 repression with mitochondrial denine nucleotide translocator, brain protein, and ADH dehydrogenase to ribonucleoprotein-induced mRNA processing in higher human left hemisphere. Our AMD1 different networks were verified by AMD1-activated or -inhibited complete and uncomplete networks within and between chimpanzee left hemisphere or (and) human left hemisphere.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 61171114), the State Key Laboratory of Drug Research (SIMM1302KF), Automatical Scientific Planning of Tsinghua University (20111081023 and 20111081010).

Conflict of interests

We have no conflict of interests.

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Authors and Affiliations

  1. Bioinformatics Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, 100876, China

    Lin Wang, Juxiang Huang, Haizhen Diao, Huilei Zhou, Xiaohe Li & Qingchun Chen

  2. State key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China

    Lin Wang

  3. Lab of Computational Linguistics, School of Humanities and Social Sciences, Tsinghua University, Beijing, 100084, China

    Minghu Jiang

  4. School of Mechanical Electronic & Information Engineering, China University of Mining & Technology, Beijing, 100083, China

    Zhenfu Jiang

  5. Dean department, Heilongjiang University of Chinese Medicine, Harbin, 150040, China

    Haitao Feng

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  1. Lin Wang
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Correspondence to Lin Wang.

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Lin Wang, Juxiang Huang and Minghu Jiang have contributed equally to this work.

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Wang, L., Huang, J., Jiang, M. et al. Adenosylmethionine Decarboxylase 1 (AMD1)-Mediated mRNA Processing and Cell Adhesion Activated & Inhibited Transition Mechanisms by Different Comparisons Between Chimpanzee and Human Left Hemisphere. Cell Biochem Biophys 70, 279–288 (2014). https://doi.org/10.1007/s12013-014-9902-y

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