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Duodenal Neuroendocrine Carcinoma Presenting with Disseminated Liver and Bone Metastases as the Primary Manifestation: Case Report and Literature Review

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Abstract

Neuroendocrine tumors are composed by a heterogeneous group of tumors with a wide range of morphologic, functional, and behavioral characteristics. These tumors are generally slow growing and behave in an indolent fashion. However, they have the potential to spread, especially for poorly differentiated neuroendocrine carcinomas, and when they do, they can be very aggressive, with high propensity for distant metastases, and difficult to treat with current modalities. As poorly differentiated neuroendocrine carcinomas rarely occur in extrapulmonary sites, to the best of our knowledge, this is the first case report of a poorly differentiated duodenal neuroendocrine carcinoma with diffuse liver and bone metastases as the primary manifestation. Despite receiving a trial of chemotherapeutic regimen, the patient had progressive intrahepatic cholestasis and died of subacute hepatic failure.

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All authors declare no potential conflicts or competing interests.

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Authors and Affiliations

  1. Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China

    Tao Guo & Jia Ming Qian

  2. Department of Gastroenterology, Centro Hospitalar Conde de S. Januario (CHCSJ), Macao, China

    Ka Kei Ng, Hoi Wan Chiang & Man Fei Ma

  3. Department of Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China

    Yi Lin

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  1. Tao Guo
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  2. Ka Kei Ng
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  3. Hoi Wan Chiang
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  6. Jia Ming Qian
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Correspondence to Tao Guo.

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Guo, T., Ng, K.K., Chiang, H.W. et al. Duodenal Neuroendocrine Carcinoma Presenting with Disseminated Liver and Bone Metastases as the Primary Manifestation: Case Report and Literature Review. Cell Biochem Biophys 72, 305–309 (2015). https://doi.org/10.1007/s12013-014-0430-6

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  • DOI: https://doi.org/10.1007/s12013-014-0430-6

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