Skip to main content

Advertisement

SpringerLink
Log in

The Study of Different Approaches of Parecoxib Sodium Pretreatment on the Behavior of Rats with Neuropathic Pain

  • Original Paper
  • Published:
Cell Biochemistry and Biophysics Aims and scope Submit manuscript

Abstract

Our objective is to analyze and observe the different administration routes of parecoxib sodium pretreatment on the behavioral improvement of rats with neuropathic pain to provide the preclinical data of parecoxib sodium on neuropathic pain treatment. 30 SD rats were randomly divided into five groups, including model group, sham operation group, intrathecal injection group (IT group), intraperitoneal injection group (IP group), and perineural infiltration group (PI group). The rats in model group and three parecoxib sodium pretreatment groups received spinal nerve ligation (SNL). Heat pain test and 50 % paw mechanical withdrawal threshold test (50 % PMWT) were use to assess the responses after parecoxib sodium pretreatment. 50 % PMWT results of right foot in five groups had no statistical difference (P > 0.05); 50 % PMWT results of left and right feet in three parecoxib sodium pretreatment groups were obviously higher than SNL group at different time points, which was statistically different (P < 0.05); in comparison with three pretreatment groups, the data of left foot in IT group were obviously higher than PI group and IP group, and the comparison among three groups had significant difference (P < 0.05). However, the data of right foot had no significant difference among three groups (P > 0.05). Paw thermal withdrawal latency (PTWL) results of left and right feet in five groups had no significant difference before surgery (P > 0.05); after the establishment of neuropathic model, PTWL results in five groups were significantly decreased; however, PTWL results of left and right feet at 3 days after surgery in IT group were significantly higher than the two other pretreatment groups (P < 0.05); PTWL results of left and right feet at 7 and 14 days after surgery had no significant difference. Parecoxib sodium pretreatment can effectively improve the behaviors caused by neuropathic pain, and intrathecal injection is the most effective route of administration.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Arle, J. E., et al. (2014). Mechanism of dorsal column stimulation to treat neuropathic but not nociceptive pain: Analysis with a computational model. Neuromodulation, 17(7), 642–655.

  2. Bohren, Y., et al. (2013). Antidepressants suppress neuropathic pain by a peripheral beta2-adrenoceptor mediated anti-TNFalpha mechanism. Neurobiology of Diseases, 60, 39–50.

    Article  CAS  Google Scholar 

  3. Kandhare, A. D., et al. (2013). Elucidation of molecular mechanism involved in neuroprotective effect of coenzyme Q10 in alcohol-induced neuropathic pain. Fundamental & Clinical Pharmacology, 27(6), 603–622.

    Article  CAS  Google Scholar 

  4. Akcakaya, M. O., et al. (2012). Cervical intradural glass fragment: A rare cause of neuropathic pain. Turkish Neurosurgery, 22(5), 667–670.

    PubMed  Google Scholar 

  5. Nakagawa, S., et al. (2011). Can milnacipran used for neuropathic pain in patients with advanced cancer cause neuromuscular and somatosensory disorders? Journal of Palliative Medicine, 14(4), 403–405.

    Article  PubMed  Google Scholar 

  6. Zenonos, G., & Kim, J. E. (2010). A T cell-orchestrated immune response in the adult dorsal spinal cord as a cause of neuropathic pain-like hypersensitivity after peripheral nerve damage: A door to novel therapies? Neurosurgery, 66(4), N24–N25.

    Article  PubMed  Google Scholar 

  7. Fishbain, D. A., et al. (2009). Does pain cause the perception of fatigue in patients with chronic pain? Findings from studies for management of diabetic peripheral neuropathic pain with duloxetine. Pain Practice, 9(5), 354–362.

    Article  PubMed  Google Scholar 

  8. Schroder, S., et al. (2013). Can medical herbs stimulate regeneration or neuroprotection and treat neuropathic pain in chemotherapy-induced peripheral neuropathy? Evidence-Based Complement and Alternative Medicine, 2013, 423713.

    Google Scholar 

  9. Eaton, M. J., Berrocal, Y., & Wolfe, S. Q. (2012). Potential for cell-transplant therapy with human neuronal precursors to treat neuropathic pain in models of PNS and CNS injury: Comparison of hNT2.17 and hNT2.19 cell lines. Pain Research and Treatment, 2012, 356412.

    PubMed Central  PubMed  Google Scholar 

  10. Hayashida, K., & Eisenach, J. C. (2008). Multiplicative interactions to enhance gabapentin to treat neuropathic pain. European Journal of Pharmacology, 598(1–3), 21–26.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Lenz, H., et al. (2011). Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans. Pain, 152(6), 1289–1297.

    Article  CAS  PubMed  Google Scholar 

  12. Liu, X., et al. (2013). Parecoxib added to ropivacaine prolongs duration of axillary brachial plexus blockade and relieves postoperative pain. Clinical Orthopaedics and Related Research, 471(2), 562–568.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Williams, D. L., Pemberton, E., & Leslie, K. (2011). Effect of intravenous parecoxib on post-craniotomy pain. British Journal of Anaesthesia, 107(3), 398–403.

    Article  CAS  PubMed  Google Scholar 

  14. Bao, Y., et al. (2012). Comparison of preincisional and postincisional parecoxib administration on postoperative pain control and cytokine response after total hip replacement. Journal of International Medical Research, 40(5), 1804–1811.

    Article  CAS  PubMed  Google Scholar 

  15. Akimoto, N., et al. (2013). CCL-1 in the spinal cord contributes to neuropathic pain induced by nerve injury. Cell Death and Disease, 4, e679.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Liu, M., et al. (2012). Analgesic effect of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on spared nerve injury rat model of neuropathic pain. Pharmacology, Biochemistry and Behavior, 102(3), 465–470.

    Article  CAS  PubMed  Google Scholar 

  17. Kim, C. F., & Moalem-Taylor, G. (2011). Interleukin-17 contributes to neuroinflammation and neuropathic pain following peripheral nerve injury in mice. Journal of Pain, 12(3), 370–383.

    Article  CAS  PubMed  Google Scholar 

  18. Guan, Y., et al. (2008). Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury. Pain, 138(2), 318–329.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Mamet, J., et al. (2014). Single intrathecal administration of the transcription factor decoy AYX1 prevents acute and chronic pain after incisional, inflammatory, or neuropathic injury. Pain, 155(2), 322–333.

    Article  CAS  PubMed  Google Scholar 

  20. Alexander, J. K., et al. (2012). Macrophage migration inhibitory factor (MIF) is essential for inflammatory and neuropathic pain and enhances pain in response to stress. Experimental Neurology, 236(2), 351–362.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  21. Zhao, J., et al. (2006). Nociceptor-derived brain-derived neurotrophic factor regulates acute and inflammatory but not neuropathic pain. Molecular and Cellular Neuroscience, 31(3), 539–548.

    Article  CAS  PubMed  Google Scholar 

  22. Quintao, N. L., et al. (2006). Long-lasting neuropathic pain induced by brachial plexus injury in mice: Role triggered by the pro-inflammatory cytokine, tumour necrosis factor alpha. Neuropharmacology, 50(5), 614–620.

    Article  CAS  PubMed  Google Scholar 

  23. Chodakiewitz, Y. G., Bicalho, G. V., & Chodakiewitz, J. W. (2013). Multi-target neurostimulation for adequate long-term relief of neuropathic and nociceptive chronic pain components. Surgical Neurology International, 4(Suppl 3), S170–S175.

    Article  PubMed Central  PubMed  Google Scholar 

  24. Zamponi, G. W. (2011). Antiallodynic effects of a confused alpha-conotoxin: Vc1.1 relieves neuropathic pain via off target actions on GABA(B) receptors and N-type channels. Pain, 152(2), 241–242.

    Article  CAS  PubMed  Google Scholar 

  25. Sakai, A., & Suzuki, H. (2008). NCAM as a target for GDNF-induced analgesia in neuropathic pain. Journal of Nippon Medical School, 75(3), 136–137.

    Article  PubMed  Google Scholar 

  26. Li, J. Z., et al. (2013). Effects of parecoxib sodium analgesia on serum concentrations of neuron-specific enolase and S-100beta and postoperative cognitive function of elderly patients undergoing acute replacement of femoral head. Zhonghua Yi Xue Za Zhi, 93(27), 2152–2154.

    CAS  PubMed  Google Scholar 

  27. Apfelbaum, J. L., et al. (2008). Multiple-day efficacy of parecoxib sodium treatment in postoperative bunionectomy pain. Clinical Journal of Pain, 24(9), 784–792.

    Article  PubMed  Google Scholar 

  28. Wiktorowska-Owczarek, A. (2013). The effect of valdecoxib on the production of growth factors evoked by hypoxia and bacterial lipopolysaccharide in HMEC-1 cells. Advances in Clinical and Experimental Medicine, 22(6), 795–800.

    PubMed  Google Scholar 

  29. Thakral, N. K., et al. (2011). The quest for targeted delivery in colon cancer: Mucoadhesive valdecoxib microspheres. International Journal of Nanomedicine, 6, 1057–1068.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  30. Keshetti, S., & Ciddi, V. (2010). Biotransformation of valdecoxib by microbial cultures. Journal of Microbiology and Biotechnology, 20(4), 809–816.

    PubMed  Google Scholar 

  31. Zall, A., et al. (2011). NSAID-derived gamma-secretase modulation requires an acidic moiety on the carbazole scaffold. Bioorganic and Medicinal Chemistry, 19(16), 4903–4909.

    Article  CAS  PubMed  Google Scholar 

  32. Valdes, A. M., et al. (2014). History of knee surgery is associated with higher prevalence of neuropathic pain-like symptoms in patients with severe osteoarthritis of the knee. Seminars in Arthritis and Rheumatism, 43(5), 588–592.

    Article  PubMed  Google Scholar 

  33. Searle, R. D., & Bennett, M. I. (2011). Neuropathic pain after thoracic surgery. Pain, 152(4), 958.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This study was funded by 2011 Research Project of Shenyang Science and Technology Bureau (F11-262-9-04).

Author information

Authors and Affiliations

  1. Department of Anesthesiology, The First Affiliated Hospital, China Medical University, NO.155 of Nanjingbei Street, Heping District, Shenyang, 110001, Liaoning, China

    Wenyao Cui, Xue Yu & Huiqian Zhang

Authors
  1. Wenyao Cui
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xue Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Huiqian Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Wenyao Cui.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cui, W., Yu, X. & Zhang, H. The Study of Different Approaches of Parecoxib Sodium Pretreatment on the Behavior of Rats with Neuropathic Pain. Cell Biochem Biophys 72, 137–140 (2015). https://doi.org/10.1007/s12013-014-0424-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12013-014-0424-4

Keywords

Search

Navigation