Abstract
The aim of this study is to explore the surgical strategies for treating Hashimoto’s disease complicated with thyroid microcarcinoma. We analyzed the clinical data of 25 patients with Hashimoto’s disease with thyroid microcarcinoma who were treated in our hospital from January 1995 to September 2011. The incidence of Hashimoto’s disease with thyroid microcarcinoma was 9.8 % (25/256) in our hospital. Amongst them, 19 patients had papillary thyroid carcinoma and six had follicular thyroid carcinoma. There were 24 cases (96 %) confirmed by the frozen section examination and one (4 %) after surgery. One patient did not undergo remedial surgery. The surgical approaches were determined based on preoperative examinations and intraoperative frozen pathology, including thyroid lobe and isthmus resection with contralateral lobe subtotal resection in 19 cases, and bilateral subtotal thyroid lobectomy in one case. Central lymph node dissection was conducted for all patients except one who was not diagnosed until after the surgery. No recurrence occurred during the follow-up (range: 6 months to 17 years) and all patients have survived to date. The preoperative diagnosis rate of Hashimoto’s disease with thyroid cancer (in particular thyroid microcarcinomas) is low. Preoperative palpation, color Doppler ultrasound, fine needle aspiration, and the frozen section examination are helpful to improve the diagnosis rate of Hashimoto’s disease with thyroid microcarcinoma. Surgery procedure is the most effective approach.
Similar content being viewed by others
References
Baudin, E., Travagli, J. P., Ropers, J., Mancusi, F., Bruno-Bossio, G., Caillou, B., et al. (1998). Microcarcinoma of the thyroid gland: The Gustave-Roussy Institute experience. Cancer, 83, 553–559.
Park, Y. J., Kim, Y. A., Lee, Y. J., Kim, S. H., Park, S. Y., Kim, K. W., et al. (2010). Papillary microcarcinoma in comparison with larger papillary thyroid carcinoma in BRAF (V600E) mutation, clinicopathological features, and immunohistochemical findings. Head and Neck, 32, 38–45.
Sakorafas, G. H., Stafyla, V., Kolettis, T., Tolumis, G., Kassaras, G., & Peros, G. (2007). Microscopic papillary thyroid cancer as an incidental finding in patients treated surgically for presumably benign thyroid disease. Journal of Postgraduate Medicine, 53, 23–26.
Di, Z. M. (2008). Diagnosis and treatment of thyroid microcarcinomas: Report of 52 cases. Chinese Journal of General Surgery, 17, 1058–1060.
He, J. H., Meng, B., Wang, G., et al. (2007). Clinical characteristics study on pathology diagnosis of thyroid nodule. Journal of Regional Anatomy and Operative Surgery, 16, 404.
Intidhar-Labidi, S., Chaabouni, A. M., Kraiem, T., Attia, N., Gritli, S., El May, A., & Ben, S. F. (2006). Thyroid carcinoma and Hashimoto thyroiditis. Ann Otolaryngol Chir Cervicofac, 123, 175–178.
Lang, W., Borrusch, H., & Bauer, L. (1988). Occult carcinoma of the thyroid. Evaluation of 1,020 sequential autopsies. American Journal of Clinical Pathology, 90, 72–76.
Simmons, J. D., Pinson, T. W., Donnellan, K. A., Harbarger, C. F., Pitman, K. T., & Griswold, R. (2010). A rare case of a 1.5 mm papillary microcarcinoma of the thyroid presenting with pituitary metastasis. American Surgeon, 76, 336–338.
Serpell, J. W., & Phan, D. (2007). Safety of total thyroidectomy. ANZ Journal of Surgery, 77, 15–19.
Unalp, H. R., Erbil, Y., Akguner, T., Kamer, E., Derici, H., & Issever, H. (2009). Does near total thyroidectomy offer advantage over total thyroidectomy in terms of postoperative hypocalcemia? International Journal of Surgery, 7, 120–125.
Liu, L. H., Bakhos, R., & Wojcik, E. M. (2001). Concomitant papillary thyroid carcinoma and Hashimoto’s thyroiditis. Seminars in diagnostic pathology, 18, 99–103.
Palestini, N., Borasi, A., Cestino, L., Freddi, M., Odasso, C., & Robecchi, A. (2008). Is central neck dissection a safe procedure in the treatment of papillary thyroid cancer? Our experience. Langenbeck’s archives of surgery. Deutsche Gesellschaft fur Chirurgie, 393, 693–698.
Singh, B., Shaha, A. R., Trivedi, H., Carew, J. F., Poluri, A., & Shah, J. P. (1999). Coexistent Hashimoto’s thyroiditis with papillary thyroid carcinoma: Impact on presentation, management, and outcome. Surgery, 126, 1070–1076.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Tao, L., Xi-lin, H. & Xiang-dong, M. Surgical Treatment of Hashimoto’s with Thyroid Microcarcinoma. Cell Biochem Biophys 72, 123–126 (2015). https://doi.org/10.1007/s12013-014-0418-2
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12013-014-0418-2