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Uric Acid as a Predictor of In-Hospital Mortality in Acute Myocardial Infarction: A Meta-analysis

Cell Biochemistry and Biophysics volume 70, pages 1597–1601 (2014)Cite this article

Abstract

Uric acid (UA) is generalized as a byproduct the terminal steps of purine catabolism, which are catalyzed by xanthine oxidoreductase. Xanthine oxidase activity and uric acid synthesis are reported to be increased under tissue ischemia. Therefore, elevated uric acid may act as a prognostic marker of acute myocardial infarction (AMI). A few studies have showed that UA is associated with therapeutic outcomes in patients with acute myocardial infarction. The purpose of this meta-analysis is to evaluate the prognostic significance of the UA as a predictor of in-hospital mortality. We performed a systematic review and included studies that used both UA and in-hospital mortality from Embase and PubMed. Six studies have been included in this review with totally 5,686 patients. During the follow-up, high UA level was found to be associated with an increased risk of in-hospital mortality [risk ratios (RR) 2.10 (1.03–4.26), number needed to harm (NNH) 37], MACE [RR 3.44 (2.33–5.08), NNH 17]. High UA level has the potential to be an important prognostic marker for in-hospital mortality in individuals with AMI.

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The authors declare that they have no conflict of interest.

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Affiliations

  1. Department of Geriatric Outpatient, The Fourth Affiliated Hospital of Harbin Medical University, 37 Yiyuan Road, Nangang District, Harbin, 150001, Heilongjiang Province, China

    Liru Yan

  2. Department of Cardiac Surgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Road, Nangang District, Harbin, 150001, Heilongjiang Province, China

    Zonghong Liu

  3. Department of Cardiac Surgery, The Fourth Affiliated Hospital of Harbin Medical University, 37 Yiyuan Road, Nangang District, Harbin, 150001, Heilongjiang Province, China

    Chaoying Zhang

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  1. Liru Yan
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  2. Zonghong Liu
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Correspondence to Zonghong Liu.

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Yan, L., Liu, Z. & Zhang, C. Uric Acid as a Predictor of In-Hospital Mortality in Acute Myocardial Infarction: A Meta-analysis. Cell Biochem Biophys 70, 1597–1601 (2014). https://doi.org/10.1007/s12013-014-0101-7

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  • DOI: https://doi.org/10.1007/s12013-014-0101-7

Keywords

  • Uric acid
  • In-hospital mortality
  • Acute myocardial infarction