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IGF1(CA)19 and IGFBP-3-202A/C Gene Polymorphism and Cancer Risk: A Meta-analysis

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Abstract

Insulin-like growth factor 1 (IGF1)(CA)19 and insulin-like growth factor-binding protein-3 (IGFBP-3)-202A/C gene polymorphisms had been focused by many epidemiological studies recently, which were associated with common cancer risk including colorectal, breast, prostate, and lung cancer. However, the findings of epidemiological investigations are not coincident. We did a systematic review and meta-analysis of case–control studies, including studies nested in cohorts, of the association between IGF1(CA)19 and IGFBP-3-202A/C gene polymorphism and prostate, colorectal, premenopausal and postmenopausal breast cancer. We identified 17 eligible studies (24 datasets), which included 9,744 cases and 11,332 controls. The result displays that individuals carrying (CA)19 allele had a subtly decreased risk of all cancer sites [OR(95 % CI) 0.92(0.87,0.97); 0.882(0.809,0.962); 0.902(0.849,0.958)] and postmenopausal breast cancer [OR(95 % CI) 0.893(0.832,0.959); 0.834(0.719,0.968); 0.862(0.776,0.958)] in allele contrast model, CA19/CA19 vs. non-CA19/non-CA19 model, and recessive genetic model. In subgroup analysis according to ethnicities, (CA)19 repeat polymorphism had an increased risk of common cancers in Asian [OR (95 % CI) of allele contrast model: 1.105(1.000,1.224); additive model: 1.103(0.844,1.441), 1.197(1.013,1.413); recessive model: 1.039(0.831,1.300); and dominant model: 1.191(1.030,1.376)]. On the other hand, IGFBP-3-202A/C gene polymorphism did not seem to be associated with all the cancer sites in any genetic model and ethnicity. In conclusion, the result of this meta-analysis indicates that the IGF1(CA)19 polymorphism is a candidate gene polymorphism for cancer susceptibility regardless of environmental factors, especially in Asian.

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Authors and Affiliations

  1. Department of Histology and Embryology, Third Military Medical University, Chongqing, 400038, People’s Republic of China

    Hongyu Quan, Hao Tang & Hongli Li

  2. Battalion 19 of the Department of Biomedical Engineering, Third Military Medical University, Chongqing, 400038, People’s Republic of China

    Hongyu Quan & Hao Tang

  3. The 169th Hospital of PLA, Dongfeng South Rd, Hengyang, 421002, People’s Republic of China

    Li Fang & Jianjun Bi

  4. Department of Military Medical Geography, Third Military Medical University, Chongqing, 400038, People’s Republic of China

    Yunsheng Liu

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  1. Hongyu Quan
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Correspondence to Yunsheng Liu or Hongli Li.

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Quan, H., Tang, H., Fang, L. et al. IGF1(CA)19 and IGFBP-3-202A/C Gene Polymorphism and Cancer Risk: A Meta-analysis. Cell Biochem Biophys 69, 169–178 (2014). https://doi.org/10.1007/s12013-013-9784-4

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