Abstract
Obestatin, encoded by the same gene as ghrelin, was first described as a physiological opponent of ghrelin. The association between circulating obestatin levels and blood pressure remains unclear. Furthermore, adequate information is non-existent regarding the older male population with hypertension. For this purpose, we enrolled 185 unrelated hypertensive male patients aged ≥80 years (range 80–102 years). One hundred seventy nine age-matched healthy subjects served as controls. Plasma levels of obestatin and insulin were measured using commercial ELISA and RIA. HOMA-IR was calculated using standard method. We found that plasma obestatin levels correlated significantly with insulin levels (P = 0.034) and homeostasis model assessment index for insulin resistance (HOMA-IR: P = 0.028). However, plasma obestatin differed non-significantly between hypertensive (5.06 ± 0.68 ng/mL) and non-hypertensive (4.72 ± 0.82 ng/mL) individuals. Plasma obestatin levels were not associated with systolic (P = 0.818) or diastolic (P = 0.564) blood pressure, waist-to-hip ratio (WHR: P = 0.725), uric acid (P = 0.603), total cholesterol (TC: P = 0.589), low-density lipoprotein cholesterol (LDL-C: P = 0.057); high-density lipoprotein cholesterol (HDL-C: P = 0.432), triglyceride (TG: P = 0.418), and fasting blood glucose (FBG: P = 0.101). We, therefore, concluded that fasting circulating obestatin levels did not directly correlate with blood pressure in men aged ≥80 years.
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This research was supported by grants from the National Natural Science Foundation of China (30600294), Natural Science Foundation of Shanghai (11ZR1429500), Science and Technology Funds from Pudong New Area (PKJ2010-Y08; PKJ2012-Y07), Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai (PWZxkq2010-05), and Academic Leaders Training Program of Pudong Health Bureau of Shanghai (PWRd2011-01).
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Li Shao, Yin-tao Zhao and Li-li Teng contributed equally to this work.
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Shao, L., Zhao, Yt., Teng, Ll. et al. Circulating Obestatin Levels Correlate with Fasting Insulin and HOMA-IR but Not with Hypertension in Elderly Men. Cell Biochem Biophys 69, 89–92 (2014). https://doi.org/10.1007/s12013-013-9772-8
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DOI: https://doi.org/10.1007/s12013-013-9772-8