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Efficacy of Repetitive Transcranial Magnetic Stimulation in the Treatment of Patients with Chronic Primary Insomnia

  • Translational Biomedical Research
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Abstract

This study assessed the efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of patients with chronic primary insomnia. Hundred and twenty patients with chronic primary insomnia were randomly assigned to three study groups (n = 40 per group): rTMS, medication, or psychotherapy treatment (both latter as controls). The treatments proceeded for 2 weeks, after which treatment efficacies were assessed in each study group based on changes in polysomnography parameters, Pittsburgh sleep quality index, and indices of HPA and HPT axes (serum cortisol, adrenocorticotropic hormone, highly sensitive thyrotropin, free T3, and free T4). Further, the relapse and recurrence rates within 3 months after respective treatments were also measured. rTMS treatment significantly better (p < 0.05) improved stage III sleep and REM sleep cycle compared with both control groups. Further, rTMS treatment group was more advantageous in improving the indices of HPA and HPT axes (p < 0.05 vs. both control groups). In addition, the relapse and recurrence rates were also the lowest in rTMS treatment group. In conclusion, rTMS treatment is more advantageous than both medication and psychotherapy treatments in improving the sleep architecture. Further, rTMS significantly decreases the body awakening level and provides a better long-term treatment effect.

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References

  1. Wang, G. (2009). The survey of the quality of sleep in general population. Healthy Psychology, 2009(10), 431.

    Google Scholar 

  2. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders. Washington, DC: American Psychiatric Association.

    Google Scholar 

  3. American Academy of Sleep Medicine. (2007). The AASM manual for the scoring of sleep and associated events: Rules, terminology and technical specifications. Westchester, IL: American Academy of Sleep Medicine.

    Google Scholar 

  4. Barker, A. T., Jalinous, R., & Freeston, I. L. (1985). Non-invasive magnetic stimulation of human motor cortex. Lancet, 1, 1106–1107.

    Article  PubMed  CAS  Google Scholar 

  5. Maeda, F., Keenan, J. P., Tormos, J. M., Topka, H., & Pascual-Leone, A. (2000). Interindividual variability of the modulatory effects of repetitive transcranial magnetic stimulation on cortical excitability. Experimental Brain Research, 133, 425–430.

    Article  CAS  Google Scholar 

  6. Strafella, A. P., Paus, T., Fraraccio, M., & Dagher, A. (2003). Striatal dopamine release induced by repetitive transcranial magnetic stimulation of the human motor cortex. Brain, 126, 2609–2615.

    Article  PubMed  Google Scholar 

  7. Riemann, D., Spiegelhalder, K., Feige, B., Voderholzer, U., Berger, M., Perlis, M., et al. (2010). The hyperarousal model of insomnia: A review of the concept and its evidence. Sleep Medicine Reviews, 14, 19–31.

    Article  PubMed  Google Scholar 

  8. Bonnet, M. H., & Arand, D. L. (2010). Hyperarousal and insomnia: State of the science. Sleep Medicine Reviews, 14, 9–15.

    Article  PubMed  Google Scholar 

  9. Cortoos, A., Verstraeten, E., & Cluydts, R. (2006). Neurophysiological aspects of primary insomnia: Implications for its treatment. Sleep Medicine Reviews, 10, 255–266.

    Article  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Sleep and Psychology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China

    Cheng-gang Jiang, Ting Zhang, Fa-guo Yue, Ming-ling Yi & Dong Gao

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  1. Cheng-gang Jiang
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  2. Ting Zhang
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  3. Fa-guo Yue
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  4. Ming-ling Yi
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  5. Dong Gao
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Correspondence to Dong Gao.

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Jiang, Cg., Zhang, T., Yue, Fg. et al. Efficacy of Repetitive Transcranial Magnetic Stimulation in the Treatment of Patients with Chronic Primary Insomnia. Cell Biochem Biophys 67, 169–173 (2013). https://doi.org/10.1007/s12013-013-9529-4

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  • DOI: https://doi.org/10.1007/s12013-013-9529-4

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