Skip to main content
SpringerLink
Log in

Resveratrol Ameliorates the Deleterious Effect of Severe Acute Pancreatitis

  • Translational Biomedical Research
  • Published:
Cell Biochemistry and Biophysics Aims and scope Submit manuscript

Abstract

Resveratrol (RES) is a traditional Chinese herbal medicine having anti-inflammatory properties. We sought to explore the role of RES in intestinal injury during severe acute pancreatitis (SAP) in a rat model study. For this purpose, RES-treated and sham-operated (SO) SAP rat models were established, and SAP was induced in rats by injecting 4% sodium taurocholate into the biliary-pancreatic duct. In the RES group, RES was infused intravenously immediately after the SAP induction in rats; SO group served as controls. Histopathological analysis, determination of tissue levels of superoxide dismutase (SOD) and malondialdehyde (MDA) and serum levels of TNF-α as well as ICAM-1 and VCAM-1 expression were carried out at 3, 6, and 12 h following SAP induction. The data show that following SAP induction, SOD levels decreased and MDA levels increased along with ICAM-1 and VCAM-1 expression in the intestine. Serum TNF-α levels increased in the SAP group. Importantly, RES treatment significantly reversed all the pathological changes. In conclusion, this study confirmed the anti-inflammatory properties of RES and demonstrated the prevention of injury to the intestinal barrier in the rat SAP model.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Steer, M. L. (1997). Pathogenesis of acute pancreatitis. Digestion, 58, 46–49.

    Article  PubMed  Google Scholar 

  2. Wu, X. Z. (2001). The combined therapy in the treatment of acute pancreatitis. Shijie Huaren Xiaohua Zazhi, 9, 417–418.

    Google Scholar 

  3. Wu, C. T., Li, Z. L., & Huang, X. C. (1999). Effect of Chinese medicine “Qing Yi Tang” and bifidobacterium mixture on intestinal bacterial translocation following acute necrotizing pancreatitis. Shijie Huaren Xiaohua Zazhi, 7, 525–528.

    Google Scholar 

  4. Bhat, K. P. L., Kosmeder, J. W., & Pezzuto, J. M. (2001). Biological effects of resveratrol. Antioxidants & Redox Signaling, 3, 1041–1064.

    Article  CAS  Google Scholar 

  5. Wang, L. C., & Ma, Q. Y. (2008). Effects of resveratrol on calcium regulation in rats with severe acute pancreatitis. European Journal of Pharmacology, 580, 271–276.

    Article  PubMed  CAS  Google Scholar 

  6. Kollar, P., & Hotolova, H. (2003). Biological effects of resveratrol and other constituents of wine. Ceská a Slovenská Farmacie, 52, 272–281.

    PubMed  CAS  Google Scholar 

  7. Meng, Y., Ma, Q. Y., Kou, X. P., & Xu, J. (2005). Effect of resveratrol on activation of nuclear factor kappa-B and inflammatory factors in rat model of acute pancreatitis. World Journal of Gastroenterology, 11, 525–528.

    PubMed  CAS  Google Scholar 

  8. Girgin, F., Karaoglu, O., Erkus, M., et al. (2000). Effects of trimetazidine on oxidant/antioxidant status in trinitrobenzenesulfonic acid-induced chronic colitis. Journal of Toxicology and Environmental Health—Part A, 59, 641–652.

    Article  PubMed  CAS  Google Scholar 

  9. Rogler, G., & Andus, T. (1998). Cytokines in inflammatory bowel disease. World Journal of Surgery, 22, 382–389.

    Article  PubMed  CAS  Google Scholar 

  10. Henninger, D. D., Panes, J., Eppihimer, M., et al. (1997). Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse. The Journal of Immunology, 158, 1825–1832.

    PubMed  CAS  Google Scholar 

  11. Segui, J., Gil, F., Gironella, M., et al. (2005). Down-regulation of endothelial adhesion molecules and leukocyte adhesion by treatment with superoxide dismutase is beneficial in chronic immune experimental colitis. Inflammatory Bowel Disease, 11, 872–882.

    Google Scholar 

  12. Reinecker, H. C., Steffen, M., Witthoeft, T., Pflueger, I., Schreiber, S., & Macdermott, R. P. (1993). Enhanced secretion of tumour necrosis factor-α, IL-6, and IL-1β by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn’s disease. Clinical and Experimental Immunology, 94, 174–181.

    Article  PubMed  CAS  Google Scholar 

  13. Neurath, M. F., Fuss, I., Pasparakis, M., et al. (1997). Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice. European Journal of Immunology, 27, 1743–1750.

    Article  PubMed  CAS  Google Scholar 

  14. Larrick, J. W., & Wright, S. C. (1990). Cytotoxic mechanism of tumor necrosis factor-α. The FASEB Journal, 4, 3215–3223.

    CAS  Google Scholar 

  15. Baeuerle, P. A., & Henkel, T. (1994). Function and activation of NF-κB in the immune system. Annual Review of Immunology, 12, 141–179.

    Article  PubMed  CAS  Google Scholar 

  16. Baldwin, A. S., Jr. (2001). Series introduction: the transcription factor NF-κB and human disease. The Journal of Clinical Investigation, 107, 3–6.

    Article  PubMed  CAS  Google Scholar 

  17. Qing, Y., Ma, Q. Y., & Dang, X. Y. (2007). Effects of resveratrol on apoptosis of oxygen free radicals of multiple organs in rats with severe acute pancreatitis. Xian Jiaotong Daxue Xuebao, 28, 572–574.

    Google Scholar 

  18. Jha, R. K., Ma, Q. Y., & Sha, H. C. (2008). The protective effect of resveratrol on the intestinal mucosal barrier in rats with severe acute pancreatitis. Medical Science Monitor, 14, 28–33.

    Google Scholar 

Download references

Acknowledgments

The authors thank the National Natural Science Foundation of China for financial support (Grant No. 81050110453) and Postdoctoral department of China.

Author information

Authors and Affiliations

  1. Department of Surgery, First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an, 710061, China

    Rajiv K. Jha, Qingyong Ma, Zhang Lei & Huanchen Sha

Authors
  1. Rajiv K. Jha
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Qingyong Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Zhang Lei
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Huanchen Sha
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Rajiv K. Jha or Qingyong Ma.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jha, R.K., Ma, Q., Lei, Z. et al. Resveratrol Ameliorates the Deleterious Effect of Severe Acute Pancreatitis. Cell Biochem Biophys 62, 397–402 (2012). https://doi.org/10.1007/s12013-011-9313-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12013-011-9313-2

Keywords

Search

Navigation