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Effect of Different Intensity Pulsed Ultrasound on the Restoration of Rat Skeletal Muscle Contusion

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Abstract

Muscle damage is a common form of injury. The incidence of muscle damage accounts for up to half of the sports injuries. The aim of this study was to investigate the effect of pulsed ultrasound on the healing process in an animal contusion injury model. SD rats (62) were randomly divided into control group (CG, 14 rats) and treatment group (48). According to the intensities of Ultrasound therapy, the treatment group was divided into 4 subgroups of 12 rats, each: A (0.25 W/cm2, US1), B (0.5 W/cm2, US2), C (0.75 W/cm2, US3) and D (0.25 W/cm2). The effectiveness of ultrasound treatment on muscle injuries was evaluated, and the optimal intensity of ultrasound in treating muscle injuries was explored. The results obtained provide experimental and theoretical evidence for the clinical effectiveness of Ultrasound therapy in treating muscle injuries.

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References

  1. Jarvinen, T. A., Jarvinen, T. L., Kaariainen, M., et al. (2007). Muscle injuries: Optimising recovery. Best Practice & Research Clinical Rheumatology, 21, 317–331.

    Article  Google Scholar 

  2. Shu, B. (Ed.). (2010). Trauma rehabilitation (1st ed.). Beijing: People’s Health Publishing Press.

    Google Scholar 

  3. McBrier, N. M., Lekan, J. M., Druhan, L. J., et al. (2007). Therapeutic ultrasound decreases mechano-growth factor messenger ribonucleic acid expression after muscle contusion injury. Archives of Physical Medicine and Rehabilitation, 88, 936–940.

    Article  PubMed  Google Scholar 

  4. Markert, C. D., Merrick, M. A., Kirby, T. E., & Devor, S. T. (2005). Nonthermal ultrasound and exercise in skeletal muscle regeneration. Archives of Physical Medicine and Rehabilitation, 86, 1304–1310.

    Article  PubMed  Google Scholar 

  5. Richard-Bulteau, H., Serrurier, B., Crassous, B., et al. (2008). Recovery of skeletal muscle mass after extensive injury: Positive effects of increased contractile activity. American Journal of Physiology and Cell Physiology, 294, C467–C476.

    Article  CAS  Google Scholar 

  6. Anderson, J. E. (2000). A role for nitric oxide in muscle repair: Nitric oxide-mediated activation of muscle satellite cells. Molecular Biology of the Cell, 11, 1859–1874.

    PubMed  CAS  Google Scholar 

  7. Rantanen, J., Thorsson, O., Wollmer, P., et al. (1999). Effects of therapeutic ultrasound on the regeneration of skeletal myofibers after experimental muscle injury. American Journal of Sports Medicine, 27, 54–59.

    PubMed  CAS  Google Scholar 

  8. Lawson-Smith, M. J., & McGeachie, J. K. (1998). The identification of myogenic cells in skeletal muscle, with emphasis on the use of tritiated thymidine autoradiography and desmin antibodies. Journal of Anatomy, 192(Pt 2), 161–171.

    Article  PubMed  Google Scholar 

  9. Fu, S. C., Shum, W. T., Hung, L. K., et al. (2008). Low-intensity pulsed ultrasound on tendon healing: A study of the effect of treatment duration and treatment initiation. American Journal of Sports Medicine, 36, 1742–1749.

    Article  PubMed  Google Scholar 

  10. Freitas, L. S., Freitas, T. P., Silveira, P. C., et al. (2007). Effect of therapeutic pulsed ultrasound on parameters of oxidative stress in skeletal muscle after injury. Cell Biology International, 31, 482–488.

    Article  PubMed  CAS  Google Scholar 

  11. Piedade, M. C., Galhardo, M. S., Battlehner, C. N., et al. (2008). Effect of ultrasound therapy on the repair of gastrocnemius muscle injury in rats. Ultrasonics, 48, 403–411.

    Article  PubMed  CAS  Google Scholar 

  12. Karnes, J. L., & Burton, H. W. (2002). Continuous therapeutic ultrasound accelerates repair of contraction-induced skeletal muscle damage in rats. Archives of Physical Medicine and Rehabilitation, 83, 1–4.

    Article  PubMed  Google Scholar 

  13. Larsen, A., Kristensen, G., Thorlacius-Ussing, O., & Oxlund, H. (2005). The influence of ultrasound on the mechanical properties of healing tendons in rabbits. Acta Orthopaedics, 76, 225–230.

    Article  Google Scholar 

  14. Amaral, A. C., Parizotto, N. A., & Salvini, T. F. (2001). Dose-dependency of low-energy HeNe laser effect in regeneration of skeletal muscle in mice. Lasers in Medical Science, 16, 44–51.

    Article  PubMed  CAS  Google Scholar 

  15. Vaittinen, S., Lukka, R., Sahlgren, C., et al. (2001). The expression of intermediate filament protein nestin as related to vimentin and desmin in regenerating skeletal muscle. Journal of Neuropathology and Experimental Neurology, 60, 588–597.

    PubMed  CAS  Google Scholar 

  16. Speed, C. A. (2001). Therapeutic ultrasound in soft tissue lesions. Rheumatology (Oxford), 40, 1331–1336.

    Article  CAS  Google Scholar 

  17. Reher, P., Doan, N., Bradnock, B., et al. (1999). Effect of ultrasound on the production of IL-8, basic FGF and VEGF. Cytokine, 11, 416–423.

    Article  PubMed  CAS  Google Scholar 

  18. Warden, S. J. (2003). A new direction for ultrasound therapy in sports medicine. Sports Medicine, 33, 95–107.

    Article  PubMed  Google Scholar 

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Correspondence to Bin Shu.

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Shu, B., Yang, Z., Li, X. et al. Effect of Different Intensity Pulsed Ultrasound on the Restoration of Rat Skeletal Muscle Contusion. Cell Biochem Biophys 62, 329–336 (2012). https://doi.org/10.1007/s12013-011-9310-5

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  • DOI: https://doi.org/10.1007/s12013-011-9310-5

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