Cell Biochemistry and Biophysics

, Volume 62, Issue 1, pp 55–58 | Cite as

Treatment with Huperzine A Improves Cognition in Vascular Dementia Patients

  • Zhi-Qiang Xu
  • Xiao-Min Liang
  • Juan-Wu
  • Yuan-Feng Zhang
  • Chun-Xia Zhu
  • Xiao-Jiang JiangEmail author
Original Paper


In the present study, we tested the efficacy and safety of Huperzine A in treatment of mild to moderate vascular dementia (VaD). This was a randomized, double-blinded, placebo-controlled study with 78 patients with mild to moderate VaD. The participants were randomized to receive either vitamin C (100-mg bid) as placebo (n = 39) or Huperzine A (0.1-mg bid) (n = 39) for 12 consecutive weeks. The mini-mental state examination (MMSE), clinical dementia rating (CDR), and activities of daily living (ADL) scores were used for the assessment of cognition. The assessments were made prior to treatment, and 4, 8, and 12 weeks of the treatment. The adverse effects of the treatment were also recorded. After 12 weeks of treatment, the MMSE, CDR, and ADL scores significantly improved in the Huperzine A group (P < 0.01 for all comparisons), whereas the placebo group did not show any such improvement (P > 0.05 for all comparisons). No serious adverse events were recorded during the treatment. Conclusion: Huperzine A can significantly improve the cognitive function in patients with mild to moderate vascular dementia. Further, the medicament is safe.


Huperzine A Vascular dementia Cognition Mini-mental state examination Clinical dementia rating Activities of daily living 



This study is supported by the Natural Science Foundation Project of CQ CSTC (2008BB5014) and the Scientific Research & Innovation Fund of the Third Military Medical University of China (2007XG063).


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Zhi-Qiang Xu
    • 1
  • Xiao-Min Liang
    • 1
  • Juan-Wu
    • 1
  • Yuan-Feng Zhang
    • 1
  • Chun-Xia Zhu
    • 1
  • Xiao-Jiang Jiang
    • 1
    Email author
  1. 1.Department of Neurology, Research Institute of SurgeryDaping Hospital, Third Military Medical UniversityChongqingChina

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