Abstract
In order to determine the clinical efficacy and adverse reactions of chemotherapy and verapamil infusion through a target artery to treat colorectal cancer patients with metastasis after failure with previous conventional treatments. Patients with metastatic colon cancer (n = 36) received an infusion of verapamil, interleukin-2, oxaliplatin (or hydroxy camptothecin or irinotecan hydrochloride), fluorouracil and calcium folinate through target artery using the Seldinger puncture technique. From the second day of infusion, the patients were treated with fluorouracil and calcium folinate via systematic intravenous injection for 2–3 days. Efficacy was evaluated after at least two treatment courses. The objective response including complete or partial response was 58.3% in the 36 patients; clinical benefit rate, evaluated by Karnofsky Performance Status score was 91.7%; by weight was 83.3%; by the amount of painkiller consumed was 80.6%. No patient experienced side effects associated with heart function. Post-treatment, the P–R period, Q–T period, QRS, and heart rate were not significantly different than before treatment. Liver function was significantly improved. Side effects of chemotherapy were minor in comparison to those observed with intravenous chemotherapy. Infusion of verapamil and chemotherapy directly into pelvic tumor tissue can increase treatment efficacy and has been shown to be a relatively safe technique.
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Herszenyi, L., & Tulassay, Z. (2010). Epidemiology of gastrointestinal and liver tumors. European Review for Medical and Pharmacological Sciences, 14, 249–258.
Oliverius, M., Safanda, M., & Petruzelka, L. (2010). Treatment of colorectal liver metastases: A current view. Klinická Onkologie, 23, 73–77.
Carlsson, G., Hafstrom, L., Jonsson, P. E., Ask, A., Kallum, B., & Lunderquist, A. (1986). Unrespectable and locally recurrent rectal cancer treated with radiotherapy or bilateral internal iliac artery infusion of 5-fluorouracil. Cancer, 58, 336–340.
Tang, Z. (2000). Modern oncology (2nd ed.). Shanghai: Shanghai Medical University.
Broelsch, C. E., Frilling, A., Bockhorn, M., Fruhauf, N., Beckebaum, S., Paul, A., et al. (2005). Surgical and interventional treatment of liver metastases. MMW Fortschritte der Medizin, 147, 21–24.
Arnold, D., Hohler, T., Dittrich, C., Lordick, F., Seufferlein, T., Riemann, J., et al. (2008). Cetuximab in combination with weekly 5-fluorouracil/folinic acid and oxaliplatin (FUFOX) in untreated patients with advanced colorectal cancer: A phase Ib/II study of the AIO GI Group. Annals of Oncology, 19, 1442–1449.
Van Cutsem, E., Kohne, C. H., Hitre, E., Zaluski, J., Chang Chien, C. R., Makhson, A., et al. (2009). Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. New England Journal of Medicine, 360, 1408–1417.
Liu, Y., Li, Y., & Tang, Y. (2010). Clinical effect of verapamil combined with chemotherapeutics in perfusion treating hydrothorax and seroperitoneum. Anhui Medical and Pharmaceutical Journal, 14, 453–455.
Seldinger, S. I. (1953). Catheter replacement of the needle in percutaneous arteriography: A new technique. Acta Radiologica, 39, 368–376.
Tsuruo, T., Iida, H., Tsukagoshi, S., & Sakurai, Y. (1982). Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors. Cancer Research, 42, 4730–4733.
Broxterman, H. J., Lankelma, J., & Pinedo, H. M. (1996). How to probe clinical tumour samples for P-glycoprotein and multidrug resistance-associated protein. European Journal of Cancer, 32A, 1024–1033.
Ford, J. M., & Hait, W. N. (1990). Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacological Reviews, 42, 155–199.
Mori, T., Iwasaki, Y., Takahashi, K., & Takahashi, T. (1992). Experimental study on adequate 5-FU dose and flow volume for continuous arterial liver infusion. Gan To Kagaku Ryoho, 19, 1547–1549.
Sumiyoshi, Y., Yokota, K., Akiyama, M., Kawaoto, H., & Kosugi, I. (1991). Tissue levels of pirarubicin (THP) in dogs following intra-arterial infusion. Gan To Kagaku Ryoho, 18, 1621–1626.
Shudo, N., Mizoguchi, T., Kiyosue, T., Arita, M., Yoshimura, A., Seto, K., et al. (1990). Two pyridine analogues with more effective ability to reverse multidrug resistance and with lower calcium channel blocking activity than their dihydropyridine counterparts. Cancer Research, 50, 3055–3061.
Ruiz Gomez, M. J., Souviron, A., Gil, L., & Martinez Morillo, M. (2001). Verapamil sensitisation to alkaloids on colchicine-selected human colon adenocarcinoma cells. Journal of Physiology and Biochemistry, 57, 343–344.
Andre, T., Boni, C., Mounedji-Boudiaf, L., Navarro, M., Tabernero, J., Hickish, T., et al. (2004). Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. New England Journal of Medicine, 350, 2343–2351.
Andre, T., Colin, P., Louvet, C., Gamelin, E., Bouche, O., Achille, E., et al. (2003). Semimonthly versus monthly regimen of fluorouracil and leucovorin administered for 24 or 36 weeks as adjuvant therapy in stage II and III colon cancer: Results of a randomized trial. Journal of Clinical Oncology, 21, 2896–2903.
de Gramont, A., Bosset, J. F., Milan, C., Rougier, P., Bouche, O., Etienne, P. L., et al. (1997). Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: A French intergroup study. Journal of Clinical Oncology, 15, 808–815.
de Gramont, A., Figer, A., Seymour, M., Homerin, M., Hmissi, A., Cassidy, J., et al. (2000). Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. Journal of Clinical Oncology, 18, 2938–2947.
Wolmark, N., Bryant, J., Smith, R., Grem, J., Allegra, C., Hyams, D., et al. (1998). Adjuvant 5-fluorouracil and leucovorin with or without interferon alfa-2a in colon carcinoma: National Surgical Adjuvant Breast and Bowel Project protocol C-05. Journal of the National Cancer Institute, 90, 1810–1816.
Russell, S. D., Saval, M. A., Robbins, J. L., Ellestad, M. H., Gottlieb, S. S., Handberg, E. M., et al. (2009). New York Heart Association functional class predicts exercise parameters in the current era. American Heart Journal, 158, S24–S30.
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Liu, Y., Lu, Z., Fan, P. et al. Clinical Efficacy of Chemotherapy Combined with Verapamil in Metastatic Colorectal Patients. Cell Biochem Biophys 61, 393–398 (2011). https://doi.org/10.1007/s12013-011-9198-0
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DOI: https://doi.org/10.1007/s12013-011-9198-0