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Genetic polymorphisms of glutathione S-transferases are associated with ulcerative colitis in central China

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Abstract

The present study aimed to investigate the association between genetic polymorphisms of glutathione S-transferases (GSTs) and susceptibility to ulcerative colitis (UC) in central China. The prevalence of GSTM1, GSTT1, and GSTP1 gene polymorphisms were examined using polymerase chain reaction methods in 270 consecutive UC patients and 623 age- and sex-matched healthy controls. The frequencies of the GSTM1(null) and GSTT1(null) as well as GSTP1 (Val/Val) genotypes were significantly higher in UC patients than in the controls (70.74% vs. 41.74%, P = 0.0001; 64.82% vs. 47.19%, P = 0.0001; and 48.89% vs. 34.35%, P = 0.0004, respectively). When the UC patients were stratified according to clinical features, we found that the frequencies of the GSTT1(null) and GSTP1 (Val/Val) genotypes but not the GSTM1(null) genotype were significantly higher in patients with distal colitis than in extensive colitis (P = 0.0007, P = 0.001, and P = 0.271, respectively). However, these variant GST genotypes were not significantly linked to severity of the disease (P > 0.05). GST variant genotypes are strongly correlated with prevalence and extent but not with severity of UC in the Hubei Han population in central China.

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Author notes

  1. Yi Jiang

    Present address: Department of Gastroenterology, The Second Hospital of Wenzhou Medical College, 325027, Wenzhou, People’s Republic of China

Authors and Affiliations

  1. Integrated Department of Wuhan University Zhongnan Hospital, 430071, Wuhan, People’s Republic of China

    Xujun Ye, Hua Wang, Ling Chen & Sheng Yuan

  2. Department of Gastroenterology, Wuhan University Zhongnan Hospital, Clinical Center of Intestinal & Colorectal Diseases of Hubei Province, Donghu Road 169, Wuhan, 430071, Hubei Province, People’s Republic of China

    Bing Xia

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  1. Xujun Ye
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  4. Ling Chen
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Correspondence to Bing Xia.

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Ye, X., Jiang, Y., Wang, H. et al. Genetic polymorphisms of glutathione S-transferases are associated with ulcerative colitis in central China. Cell Biochem Biophys 60, 323–328 (2011). https://doi.org/10.1007/s12013-011-9154-z

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