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Expression and Biological Significance of Leptin, Leptin Receptor, VEGF, and CD34 in Colorectal Carcinoma

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Abstract

To investigate the expression and biological significance of Leptin, Leptin receptor, Vascular Endothelial Growth Factor (VEGF), and CD34 protein in colorectal carcinoma tissues. The expression of Leptin, Leptin receptor, VEGF, and CD34 was detected in 68 cases of colorectal carcinoma tissues, paired para-carcinoma tissues and normal colorectal tissues by Immunohistochemical SP Method. The results and related clinicopathological data were analyzed. The positive rate of Leptin, Leptin receptor, and VEGF was significantly higher in colorectal carcinoma tissues than that in paired para-carcinoma tissues and normal colorectal tissues. The expression of Leptin, Leptin receptor, and VEGF was correlated with grade of tumor differentiation, depth of bowel wall invasion, lymph node metastasis, Dukes stage, distant metastasis, and lympho/vascular tumor embolization. Microvessel density (MVD) value in colorectal carcinoma was significantly higher than that in para-carcinoma tissues and normal colorectal tissues, and the density in para-carcinoma tissues was higher than that in normal colorectal tissues. The expression of Leptin, Leptin receptor, VEGF, and MVD value in colorectal carcinoma was positively correlated. In conclusion, microvessel density value is an important index of the growth, invasion, and metastasis of colorectal carcinoma. The binding of Leptin and Leptin receptor promotes the proliferation of colorectal carcinoma cells. The synergy between Leptin and VEGF accelerates the angiogenesis in colorectal carcinoma and accelerates the invasion and metastasis of the tumor cells.

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Authors and Affiliations

  1. Department of Colorectal Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China

    Liu Hui, Wan Desen, Pan Zhizhong, Wu Xiaojun & Lu Zhenhai

  2. College of Traditional Chinese Medicine, Hebei Medical University, Shijiazhuang, Hebei, 050091, People’s Republic of China

    Cao Lijing

  3. The Second Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, People’s Republic of China

    Kang Tai

Authors
  1. Liu Hui
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  2. Wan Desen
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  3. Pan Zhizhong
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  4. Cao Lijing
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  5. Wu Xiaojun
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  6. Lu Zhenhai
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  7. Kang Tai
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Correspondence to Wan Desen.

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Hui, L., Desen, W., Zhizhong, P. et al. Expression and Biological Significance of Leptin, Leptin Receptor, VEGF, and CD34 in Colorectal Carcinoma. Cell Biochem Biophys 60, 241–244 (2011). https://doi.org/10.1007/s12013-010-9145-5

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  • DOI: https://doi.org/10.1007/s12013-010-9145-5

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