Cell Biochemistry and Biophysics

, Volume 48, Issue 2–3, pp 177–182 | Cite as

Deleting islet autoimmunity

  • Edwin Liu
  • Marcella Li
  • Jean Jasinski
  • Masakazu Kobayashi
  • Roberto Gianani
  • Maki Nakayama
  • George S. EisenbarthEmail author
Original Paper


Even though there are numerous autoantigens for type 1 diabetes, current evidence suggests that a single autoantigen, namely insulin, is responsible for the key initiating event in autoimmunity. If a single autoantigen is necessary for triggering the autoimmune process, then antigen-specific therapy to block or delete the immune response against that autoantigen before epitope spreading occurs, may become a larger focus of future immunotherapeutic strategies. In this article, we review current literature regarding insulin as an autoantigen and potential approaches to deleting insulin-reactive T cells through the use of peptide vaccines and targeted T cell receptor immunizations.


Diabetes Deletional therapy B:9-23 NOD mouse BDC12-4.1 Insulin knockout 



Research supported by NIH (R01 DK32083, DK32493, DK 55969, DK 06218, DK06405); Immune Tolerance Network (AI 15416); Diabetes Endocrine Research Center (DK 057516); Autoimmunity Prevention Center (AI 50864); and Clinical Research Centers Program (M01 RR00069, M01RR00051), American Diabetes Foundation, Juvenile Diabetes Foundation, and the Children’s Diabetes Foundation.


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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Edwin Liu
    • 1
  • Marcella Li
    • 1
  • Jean Jasinski
    • 1
  • Masakazu Kobayashi
    • 1
  • Roberto Gianani
    • 1
  • Maki Nakayama
    • 1
  • George S. Eisenbarth
    • 1
    Email author
  1. 1.Barbara Davis Center for Childhood Diabetes, Department of PediatricsUniversity of Colorado Health Sciences CenterAuroraUSA

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