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Clinical Value of Circulating ZFAS1 and miR-590-3p in the Diagnosis and Prognosis of Chronic Heart Failure

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Abstract

Long non-coding RNAs (lncRNAs) have been reported to be involved in the development of various cardiovascular diseases, including chronic heart failure (CHF). In this study, we aimed to investigate the role of ZFAS1/miR-590-3p axis in the diagnosis and prognosis of CHF. The expression of ZFAS1 and miR-590-3p in the serum samples of CHF was measured using quantitative real-time polymerase chain reaction. Pearson correlation coefficient was applied to analyze the correlation between ZFAS1 and miR-590-3p. The receiver operating characteristic (ROC) curve was used to examine the diagnostic accuracy of ZFAS1, miR-590-3p, and brain natriuretic peptide (BNP). The Kaplan–Meier curve and Cox regression analysis were used to assess the prognostic value of ZFAS1 and miR-590-3p in CHF. This study found that the serum levels of ZFAS1 were significantly higher, while miR-590-3p levels were significantly lower in CHF. ROC results indicated that the combined diagnostic accuracy of ZFAS1 + miR-590-3p + BNP was significantly higher than that of these indicators used alone. Kaplan– Meier results showed that patients with low expression of miR-590-3p or high expression of ZFAS1 had poor prognosis. In conclusion, CHF patients had increased ZFAS1 and decreased miR-590-3p expression. ZFAS1 and miR-590-3p might serve as novel non-invasive diagnostic and prognostic markers for patients with CHF.

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Data Availability

All data generated or analyzed during this study are included in this published article.

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Funding

A Scientific Research Project of Weifang Health Commission (WFWSJK-2020-283).

Author information

Author notes

  1. Guannan Chang and Wenqing Zhang have contributed equally to this work.

Authors and Affiliations

  1. Department of Cardiology, Yidu Central Hospital of Weifang, No. 4138 Linglongshan South Road, Qingzhou City, 262500, Shandong, China

    Guannan Chang & Meicheng Zhang

  2. Department of Geriatrics, Yidu Central Hospital of Weifang, Weifang, 262500, Shandong, China

    Wenqing Zhang

  3. Department of Science and Education, Yidu Central Hospital of Weifang, Weifang, 262500, Shandong, China

    Gang Ding

Authors
  1. Guannan Chang
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  2. Wenqing Zhang
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  3. Meicheng Zhang
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  4. Gang Ding
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Contributions

GC and MZ carried out the research design and conception; WZ and MZ analyzed and interpreted the data; WZ and GD performed the examination of cell; and GC, WZ, and GD wrote and revised the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Guannan Chang.

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The authors declare that they have no competing interests.

Ethical Approval

The experimental procedures were all in accordance with the guideline of the Ethics Committee of Yidu Central Hospital of Weifang and were approved by the Ethics Committee of Yidu Central Hospital of Weifang.

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A signed written informed consent was obtained from each participant.

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Written informed consent for publication was obtained from each participant.

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Handling Editor: Y. James Kang.

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Chang, G., Zhang, W., Zhang, M. et al. Clinical Value of Circulating ZFAS1 and miR-590-3p in the Diagnosis and Prognosis of Chronic Heart Failure. Cardiovasc Toxicol 21, 880–888 (2021). https://doi.org/10.1007/s12012-021-09678-7

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  • DOI: https://doi.org/10.1007/s12012-021-09678-7

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