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Myocardial Repolarization Parameters and Neutrophil-to-Lymphocyte Ratio are Associated with Cardiotoxicity in Carbon Monoxide Poisoning

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Abstract

The present study aims to examine the clinical values of complete blood count (CBC) bioindicators and corrected QT (QTc), Tpeak − Tend interval (Tp−e), Tpeak dispersion (Tp disp), and Tp−e/QT ratio that are the parameters of myocardial repolarization (M-rep) for cardiotoxicity, which develops due to acute carbon monoxide (CO) intoxication in patients admitted to the emergency service. This retrospective, cross-sectional, observational, and single-center study was conducted between April and June 2019. Statistical analysis was performed using the SPSS 23.0 software. Data of 234 participants were analyzed. Of these, 54.9% (n = 129) were female. Neutrophil-to-lymphocyte ratio (NLR), QTc, Tp–e values were significantly high in the CO intoxication group (p < 0.001, p < 0.001, and p < 0.001, respectively), whereas Tp−e/QTc ratio was significantly lower in the CO intoxication group than that in the control group (p < 0.001). NLR, Tp−e, Tp disp values were significantly high in the myocardial injury (M-inj) group (p < 0.001, p = 0.003, and p = 0.018, respectively). Furthermore, Tp−e/QTc ratio was significantly low in the M-inj group (p = 0.002). M-rep parameters and NLR are associated with CO intoxication and the development of M-inj. Moreover, these bioindicators and can provide clinicians an early indication of M-inj.

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Authors and Affiliations

  1. Department of Emergency Medicine, University of Health Sciences, 06800, Ankara, Turkey

    Tuğba Atmaca Temrel

  2. Department of Emergency Medicine, Gulhane Education and Research Hospital, University of Health Scicences, Ankara, Turkey

    Sedat Bilge

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  1. Tuğba Atmaca Temrel
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  2. Sedat Bilge
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Correspondence to Tuğba Atmaca Temrel.

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Temrel, T.A., Bilge, S. Myocardial Repolarization Parameters and Neutrophil-to-Lymphocyte Ratio are Associated with Cardiotoxicity in Carbon Monoxide Poisoning. Cardiovasc Toxicol 20, 190–196 (2020). https://doi.org/10.1007/s12012-019-09560-7

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