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Cardiovascular Toxicology

, Volume 19, Issue 3, pp 198–209 | Cite as

Combustion Particle-Induced Changes in Calcium Homeostasis: A Contributing Factor to Vascular Disease?

  • Jørn A. HolmeEmail author
  • Bendik C. Brinchmann
  • Eric Le Ferrec
  • Dominique Lagadic-Gossmann
  • Johan ØvrevikEmail author
Article
  • 103 Downloads

Abstract

Air pollution is the leading environmental risk factor for disease and premature death in the world. This is mainly due to exposure to urban air particle matter (PM), in particular, fine and ultrafine combustion-derived particles (CDP) from traffic-related air pollution. PM and CDP, including particles from diesel exhaust (DEP), and cigarette smoke have been linked to various cardiovascular diseases (CVDs) including atherosclerosis, but the underlying cellular mechanisms remain unclear. Moreover, CDP typically consist of carbon cores with a complex mixture of organic chemicals such as polycyclic aromatic hydrocarbons (PAHs) adhered. The relative contribution of the carbon core and adhered soluble components to cardiovascular effects of CDP is still a matter of discussion. In the present review, we summarize evidence showing that CDP affects intracellular calcium regulation, and argue that CDP-induced impairment of normal calcium control may be a critical cellular event through which CDP exposure contributes to development or exacerbation of cardiovascular disease. Furthermore, we highlight in vitro research suggesting that adhered organic chemicals such as PAHs may be key drivers of these responses. CDP, extractable organic material from CDP (CDP-EOM), and PAHs may increase intracellular calcium levels by interacting with calcium channels like transient receptor potential (TRP) channels, and receptors such as G protein-coupled receptors (GPCR; e.g., beta-adrenergic receptors [βAR] and protease-activated receptor 2 [PAR-2]) and the aryl hydrocarbon receptor (AhR). Clarifying a possible role of calcium signaling and mechanisms involved may increase our understanding of how air pollution contributes to CVD.

Keywords

Diesel exhaust particles Polycyclic aromatic hydrocarbons Endothelial dysfunction Aryl hydrocarbon receptor Calcium signaling 

Abbreviations

ADRs

Adrenergic receptors

AhR

Aryl hydrocarbon receptor

ARNT

AhR nuclear translocator

B[a]P

Benzo[a]pyrene

CVD

Cardiovascular diseases

CDP

Combustion-derived particles

CYP

Cytochrome P450

[Ca2+]i

Cytosolic concentration of calcium

DEP

Diesel exhaust particles

DEP-EOM

Extractable organic material of DEP

GPCRs

G protein-coupled receptors

MMPs

Matrix metalloproteinases

NF-κB

Nuclear factor-κB

1-NP

1-nitropyrene

OC

Organic chemicals

oxLDL

Oxidized low-density lipoproteins

PM

Particular matter

PAHs

Polycyclic aromatic hydrocarbons

PAR-2

Protease-activated receptor 2

ROS

Reactive oxygen species

ROCE

Receptor-operated calcium entry

RTKs

Receptor tyrosine kinases

TRP

Transient receptor potential

SOCE

Store-operated calcium entry

XREs

Xenobiotic response elements

Notes

Author Contributions

JAH and BCB drafted the first version of the manuscript and wrote the final version in collaboration with ELF, DLG, and JØ. All authors read, commented, and approved the final manuscript.

Funding

The work was supported by the Research Council of Norway, through the Environmental Exposures and Health Outcomes- and Better Health programs (Grants No. 228143 and 260381).

Compliance with Ethical Standards

Conflict of interest

The authors declare no conflict of interests.

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Air Pollution and Noise, Division of Infection Control, Environment and HealthNorwegian Institute of Public HealthOsloNorway
  2. 2.Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé environnement et travail) - UMR_S 1085RennesFrance
  3. 3.Department of Biosciences, Faculty of Mathematics and Natural SciencesUniversity of OsloOsloNorway

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