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Flecainide-Induced Left Ventricular Dysfunction: Fact or Fiction?

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References

  1. Tamargo, J., Capucci, A., & Mabo, P. (2012). Safety of flecainide. Drug Safety, 35(4), 273–289.

    Article  CAS  PubMed  Google Scholar 

  2. Brazil, E., Bodiwala, G. G., & Bouch, D. C. (1998). Fatal flecainide intoxication. Journal of Accident and Emergency Medicine, 15(6), 423–425.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Holmes, B., & Heel, R. C. (1985). Flecainide; a preliminary review of its pharmacodynamic properties and therapeutic efficacy. Drugs, 29(1), 1–33.

    Article  CAS  PubMed  Google Scholar 

  4. Roden, D. M., & Woosley, R. L. (1986). Drug therapy: Flecainide. The New England Journal of Medicine, 315(1), 36–41.

    Article  CAS  PubMed  Google Scholar 

  5. Winkelmann, B. R., & Leinberger, H. (1987). Life-threatening flecainide toxicity: A pharmacodynamic approach. Annals of Internal Medicine, 106(6), 807–814.

    Article  CAS  PubMed  Google Scholar 

  6. Kihara, Y., Inoko, M., Hatakeyama, N., Momose, Y., & Sasayama, S. (1996). Mechanisms of negative inotropic effects of class Ic antiarrhythmic agents: Comparative study of the effects of flecainide and pilsicainide on intracellular calcium handling in dog ventricular myocardium. Journal of Cardiovascular Pharmacology, 27(1), 42–51.

    Article  CAS  PubMed  Google Scholar 

  7. Camm, J. (2012). Antiarrhythmic drugs for the maintenance of sinus rhythm: Risks and benefits. International Journal of Cardiology, 155, 362–371.

    Article  PubMed  Google Scholar 

  8. Josephson, M. A., Ikeda, N., & Singh, B. N. (1984). Effects of flecainide on ventricular function: Clinical and experimental correlations. The American Journal of Cardiology, 53(5), 95B–100B.

    Article  CAS  PubMed  Google Scholar 

  9. Legrand, V., Vandormael, M., Collignon, P., & Kulbertus, H. E. (1983). Hemodynamic effects of a new antiarrhythmic agent, flecainide (R-818), in coronary heart disease. The American Journal of Cardiology, 51(3), 422–426.

    Article  CAS  PubMed  Google Scholar 

  10. Santinelli, V., Arnese, M., & Oppo, I. (1993). Effects of flecainide and propafenone on systolic performance in subjects with normal cardiac function. Chest, 103(4), 1068–1073.

    Article  CAS  PubMed  Google Scholar 

  11. Brembilla-Perrot, B., Amor, M., & Auque, F. (1987). Effect of flecainide on left ventricular ejection fraction. European Heart Journal, 8(7), 754–761.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, Section of Cardiology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA

    Umair Khalid, Francia Rojas & Nasser Lakkis

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  1. Umair Khalid
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  2. Francia Rojas
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  3. Nasser Lakkis
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Correspondence to Umair Khalid.

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The authors declare no competing interests. There has been no prior publication of any part of this manuscript. The manuscript is not under consideration or review at any other journal.

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Khalid, U., Rojas, F. & Lakkis, N. Flecainide-Induced Left Ventricular Dysfunction: Fact or Fiction?. Cardiovasc Toxicol 17, 494–495 (2017). https://doi.org/10.1007/s12012-017-9410-6

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  • DOI: https://doi.org/10.1007/s12012-017-9410-6

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