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Cardiovascular Toxicology

, Volume 17, Issue 2, pp 185–189 | Cite as

The Correlation Between 9p21 Chromosome rs4977574 Polymorphism Genotypes and the Development of Coronary Artery Heart Disease

  • Oushan Tang
  • Jin Lv
  • Yinhong Cheng
  • Fengming Qin
Article
  • 176 Downloads

Abstract

Our aim is to investigate the correlation between 9p21 chromosome rs4977574 polymorphism genotypes and the development of coronary artery heart disease (CHD). Two hundred and eighty-nine patients with angiography-confirmed CHD were recruited as the CHD group, while 338 subjects without CHD symptoms were enrolled as the control group. For all participating subjects, the genotypes of rs4977574 polymorphism were examined by the real-time PCR analysis. Analyses acquired from single-locus technique showed that genotype distribution of rs4977574 polymorphism was significantly different (p = 0.041) between CHD group and the control group. Logistic regression analysis demonstrated that rs4977574 polymorphism in a dominant mode significantly increased (p = 0.038) the risk of CHD, where odds ratio (OR) was 0.71 and the 95 % confidence interval (CI) 0.58–0.97 was applied. 9p21 chromosome rs4977574 polymorphism genotypes are associated with the incidence and development of CHD. The presence of C allele may reduce the risk of CHD.

Keywords

Coronary artery heart disease Gene polymorphism Glycosylated hemoglobin 

Abbreviations

CHD

Coronary heart disease

OR

Odds ratio

CI

Confidence interval

LDL-C

Low-density lipoprotein cholesterol

HDL

High-density lipoprotein

TT

Homozygous genotype for the T allele

TC

T/C heterozygous genotype

CC

Homozygous for the C allele

SNP

Single nucleotide polymorphism

Notes

Author Contributions

O.T., J.L., and Y.C. carried out the study and statistical analysis and drafted the manuscript. OT and FQ participated in the experiment design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.

Compliance with Ethical Standards

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Oushan Tang
    • 1
  • Jin Lv
    • 1
  • Yinhong Cheng
    • 1
  • Fengming Qin
    • 1
  1. 1.Department of CardiologySecond Hospital of ShaoxingShaoxingChina

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