The Correlation Between 9p21 Chromosome rs4977574 Polymorphism Genotypes and the Development of Coronary Artery Heart Disease
- 154 Downloads
Our aim is to investigate the correlation between 9p21 chromosome rs4977574 polymorphism genotypes and the development of coronary artery heart disease (CHD). Two hundred and eighty-nine patients with angiography-confirmed CHD were recruited as the CHD group, while 338 subjects without CHD symptoms were enrolled as the control group. For all participating subjects, the genotypes of rs4977574 polymorphism were examined by the real-time PCR analysis. Analyses acquired from single-locus technique showed that genotype distribution of rs4977574 polymorphism was significantly different (p = 0.041) between CHD group and the control group. Logistic regression analysis demonstrated that rs4977574 polymorphism in a dominant mode significantly increased (p = 0.038) the risk of CHD, where odds ratio (OR) was 0.71 and the 95 % confidence interval (CI) 0.58–0.97 was applied. 9p21 chromosome rs4977574 polymorphism genotypes are associated with the incidence and development of CHD. The presence of C allele may reduce the risk of CHD.
KeywordsCoronary artery heart disease Gene polymorphism Glycosylated hemoglobin
Coronary heart disease
Low-density lipoprotein cholesterol
Homozygous genotype for the T allele
T/C heterozygous genotype
Homozygous for the C allele
Single nucleotide polymorphism
O.T., J.L., and Y.C. carried out the study and statistical analysis and drafted the manuscript. OT and FQ participated in the experiment design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.
Compliance with Ethical Standards
Conflict of interest
- 8.Lee, I. T., Goodarzi, M. O., Lee, W. J., et al. (2014). The chromosome 9p21 variant not predicting long-term cardiovascular mortality in chinese with established coronary artery disease: An eleven-year follow-up study. Biomed Research International, 2014, 626907. doi: 10.1155/2014/626907.PubMedPubMedCentralGoogle Scholar
- 15.Preuss, M., Konig, I. R., Thompson, J. R., et al. (2010). Design of the coronary artery disease genome-wide replication and meta-analysis (CARDIoGRAM) study: A genome-wide association meta-analysis involving more than 22000 cases and 60000 controls. Circulation Cardiovascular Genetics, 3, 475–483.CrossRefPubMedPubMedCentralGoogle Scholar