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Effect of Boric Acid on Metabolic Peptides and Some Biochemical Parameters in Experimental Diabetic Rats

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A Correction to this article was published on 10 November 2023

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Abstract

Boron (B) is an element that has recently been wondered and researched in many fields, especially due to its effects on energy metabolism. The aim of this study is to evaluate the effect of boric acid (BA) on newly discovered energy metabolism peptides that have not been studied before. In this study, the effects of 15 mg/kg of BA were evaluated in 24 Wistar rats. Groups were named as control group, 15 mg/kg BA group, streptozotocin (STZ)-induced experimental diabetic group, and STZ-induced experimental diabetic + 15 mg/kg BA administered group (STZ+15 mg/kg BA). Serum asprosin, nesfatin-1, preptin, insulin, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), aspartate transaminase (AST), alanine transaminase (ALT), and glucose analyses were performed. In this study, the increase in glucose, TG, TC, LDL-C levels, and AST, ALT activities in STZ-induced groups were reduced with BA administration. While HDL-C level significantly decreased in the STZ group, the level approached the control group values after BA administration (p<0.001). As for peptides, although there was a statistically significant increase after 15 mg/kg BA administration, these levels did not approach the control group values (p<0.001). According to the findings, STZ-induced diabetes mellitus and the biochemical processes that develop accordingly change correlatively. This study showed that BA is effective in energy metabolism.

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Authors and Affiliations

  1. Department of Medical Services and Techniques, Medical Laboratory Techniques Program, Vocational School of Health Services, Çanakkale, Turkey

    Selcen ÇAKIR

  2. Vocational School of Health Services, Çanakkale Onsekiz Mart University, Terzioğlu Campus, SHMYO Z-9. PK:17000, Çanakkale, Turkey

    Selcen ÇAKIR

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Selcen CAKIR wrote the manuscript and conducted experiments, analyzed the data, and revised the manuscript. The author approved the final draft.

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Correspondence to Selcen ÇAKIR.

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The study was approved by Çanakkale Onsekiz Mart University Animal Experiments Local Ethics Committee (ÇOMÜ HADYEK 30.06.2020; 2020/06-05).

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Further studies are required to better monitor the effect of BA on energy metabolism.

The original online version of this article was revised: the tables and figures have been updated

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ÇAKIR, S. Effect of Boric Acid on Metabolic Peptides and Some Biochemical Parameters in Experimental Diabetic Rats. Biol Trace Elem Res 202, 1001–1008 (2024). https://doi.org/10.1007/s12011-023-03910-x

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