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The Association Between Essential Metal Element Mixture and Sleep Quality in Chinese Community-Dwelling Older Adults

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Abstract

Previous studies have related single essential metal elements (EMEs) to sleep quality among older adults, however, the association of the EME mixture with sleep quality remained poorly understood. This study aimed to investigate the relationships between single EMEs and the EME mixture and sleep quality in older adults living in Chinese communities. This study consisted of 3957 older adults aged 60 years or over. Urinary concentrations of cobalt (Co), vanadium (V), selenium (Se), molybdenum (Mo), strontium (Sr), calcium (Ca), and magnesium (Mg) were detected using inductively coupled plasma mass spectrometry. Sleep quality was evaluated using Pittsburgh Sleep Quality Index (PSQI). The associations of single EMEs and EME mixture with sleep quality were assessed using logistic regression and Bayesian kernel machine regression (BKMR) models, respectively. Adjusted single-element logistic regression models showed that Mo (OR = 0.927, 95%CI:0.867–0.990), Sr (OR = 0.927, 95%CI:0.864–0.994), and Mg (OR = 0.934, 95%CI:0.873–0.997) were negatively related to poor sleep quality. BKMR models exhibited similar results. Also, higher levels of the EME mixture in urine were inversely related to the odds of poor sleep quality after adjustment for covariates, and Mo had the largest conditional posterior inclusion probability (condPIP) value in the mixture. Mo, Sr, and Mg were negatively related to poor sleep quality, separately and as the mixture. The EME mixture in urine was associated with decreased odds of poor sleep quality in older adults, and Mo was the greatest contributor within the mixture. Additional cohort research is warranted to clarify the relationship of multiple EMEs with sleep quality.

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Data Availability

The datasets analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors would like to thank all participants and the research group on the Health of Older Adults and Modifiable Factors, the Fuyang Center for Disease Control and Prevention. We are grateful to the Scientific Research Center in Preventive Medicine, School of Public Health, Anhui Medical University for the technical support in our experiment.

Funding

This study was supported by Major Projects on College Leading Talent Team Introduced of Anhui [grant number 0303011224], the Key Scientific Research Fund of Anhui Provincial Education Department [grant number KJ2017A189], Grants for Scientific Research of BSKY from Anhui Medical University [grant number Xj201525], Investigation on the Use of Microecological Agents for the Community-dwelling Older Adults in Hefei City, Anhui Province [grant number 2017062], and Investigation and Analysis of Residents’ Diseases in Fuyang City [grant number 2018160].

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  1. Hongli Wang, Yan Zhang and Huaibiao Li have equal contributions to this work.

Authors and Affiliations

  1. School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China

    Hongli Wang, Yan Zhang, Junzhe Li, Qiang Liu, Yuan Wang & Linsheng Yang

  2. Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, 230032, Anhui, China

    Hongli Wang, Yan Zhang, Guimei Chen, Dongmei Zhang, Fangbiao Tao & Linsheng Yang

  3. Fuyang Center for Diseases Prevention and Control, Fuyang, 236069, Anhui, China

    Huaibiao Li, Liang Sun & Bing Hu

  4. School of Health Services Management, Anhui Medical University, Hefei, 230032, Anhui, China

    Guimei Chen & Dongmei Zhang

  5. School of Public Health, Department of Hygiene Inspection and Quarantine, Anhui Medical University, Hefei, 230032, Anhui, China

    Chunmei Liang, Jingyuan Lei & Panpan Wang

  6. Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People’s Republic of China, Hefei, 230032, Anhui, China

    Chunmei Liang & Fangbiao Tao

  7. NHC Key Laboratory of Study On Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, 230032, Anhui, China

    Chunmei Liang

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Contributions

Hongli Wang, Yan Zhang, Huaibiao Li: Writing-original draft, Formal analysis, Validation. Junzhe Li, Qiang Liu, Yuan Wang, Guimei Chen: Investigation, Data curation, Validation. Liang Sun, Bing Hu, Dongmei Zhang: Investigation, Validation. Chunmei Liang, Fangbiao Tao: Methodology, Investigation, Validation. Jingyuan Lei, Panpan Wang: Investigation, Data curation. Linsheng Yang: Investigation, Data curation, Methodology, Writing – review & editing, Validation. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Linsheng Yang.

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The biomedical ethics board at Anhui Medical University (No. 20190288) approved our study protocol.

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Wang, H., Zhang, Y., Li, H. et al. The Association Between Essential Metal Element Mixture and Sleep Quality in Chinese Community-Dwelling Older Adults. Biol Trace Elem Res 202, 900–912 (2024). https://doi.org/10.1007/s12011-023-03729-6

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