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Selenium Biomarkers and Their Relationship to Cardiovascular Risk Parameters in Obese Women

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Abstract

A cross-sectional study was carried out with 210 women divided into a case group (obese, n = 84) and a control group (eutrophic, n = 126). Body weight, height, waist circumference (WC), and hip and neck circumference were measured and the waist-hip ratio and conicity index were calculated. Selenium in plasma, erythrocytes and urine, erythrocyte GPx activity, lipid profile, Castelli I and II indices, and systolic and diastolic blood (DBP) pressure were evaluated. Mean dietary selenium intake (µg/kg/day) and plasma and erythrocyte concentrations were lower in the obese group compared to the healthy group (p < 0.001). while urinary selenium concentrations were higher (p < 0.001). There was a statistical difference between groups regarding cardiovascular risk parameters: waist circumference, neck circumference, waist-hip ratio, conicity index, triacylglycerols (TGC), and lipoproteins rich in triacylglycerols (VLDL-c) (p > 0.05). There was a negative correlation between plasma selenium concentrations and total cholesterol (TC), non-high-density lipoprotein (non-HDL), low-density lipoprotein (LDL-c), and systolic blood pressure (SBP). Urinary selenium correlated negatively with waist circumference and hip circumference and positively with neck circumference, TC, TGC, high-density lipoprotein (HDL-c), non-HDL, and VLDL-c. There was a negative correlation between dietary selenium and waist circumference, waist-hip ratio, neck circumference, conicity index, non-HDL cholesterol, LDL-c, and Castelli indices I and II, as well as a positive correlation with HDL-c and diastolic blood pressure. Women with obesity present changes in their nutritional status related to selenium, as well as increased cardiovascular risk parameters. Thus, the positive role of selenium in protecting the risk of cardiovascular disease is likely.

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Data Availability

The dataset that support the results and findings of this research are available from [DM], upon request.

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Authors and Affiliations

  1. Department of Nutrition, Federal University of Piaui, Teresina, Brazil

    Bruna Emanuele Pereira Cardoso, Tamires da Cunha Soares, Thaline Milany da Silva Dias, Larissa Cristina Fontenelle, Jennifer Beatriz Silva Morais, Kyria Jayanne Climaco Cruz, Mickael de Paiva Sousa, Thayanne Gabryelle Visgueira de Sousa, Stéfany Rodrigues de Sousa Melo & Loanne Rocha dos Santos

  2. School of Nursing, Federal University, Minas Gerais, Belo Horizonte, Brazil

    Gilberto Simeone Henriques

  3. Med Imagem Clinical Laboratory, Teresina, Piauí, Brazil

    Francisco Erasmo Oliveira

  4. Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui, Teresina, Brazil

    Dilina do Nascimento Marreiro

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  1. Bruna Emanuele Pereira Cardoso
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  2. Tamires da Cunha Soares
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  3. Thaline Milany da Silva Dias
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  4. Larissa Cristina Fontenelle
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Contributions

Cardoso BE, Morais JBS, Cruz KJC, Santos LR, Melo SRS, and Dias TM have participated to the redaction and the review of the manuscript; Cardoso BE, Morais JBS, Sores TC, Cruz KJC, Santos LR, Fontenelle LC, Sousa MP, Sousa TGV, Sores TC, Melo SRS, Oliveira FE, and Freitas ST have participated to generation, collection, assembly, analysis, and/or interpretation of data; Silva MT and Henriques GS analysis and/or interpretation of data; Cardoso BE and Marreiro DN had supervised the paper and participated in the redaction and the review of the paper.

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Correspondence to Bruna Emanuele Pereira Cardoso.

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Cardoso, B.E.P., da Cunha Soares, T., da Silva Dias, T.M. et al. Selenium Biomarkers and Their Relationship to Cardiovascular Risk Parameters in Obese Women. Biol Trace Elem Res 202, 866–877 (2024). https://doi.org/10.1007/s12011-023-03726-9

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