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Association of CYP19A1 Gene, Plasma Zinc, and Urinary Zinc with the Risk of Type 2 Diabetes Mellitus in a Chinese Population

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Abstract

To explore the effects of CYP19A1 gene polymorphisms, plasma zinc, and urinary zinc levels and their interactions on type 2 diabetes mellitus (T2DM) in residents of Gongcheng County, Guangxi, China. The case–control study was used for the investing. The MassARRAY System was applied to genotype the CYP19A1 genes rs752760, rs10046, rs10459592, and rs700518 in 540 study subjects. Plasma and urinary zinc concentrations were measured by inductively coupled plasma mass spectrometry (ICP-MS). Conditional logistic regression showed that rs752760 and plasma zinc were associated with T2DM risks with ORs of 0.593 (95% CI: 0.371–0.948) and 0.563 (95% CI: 0.356–0.889), respectively. Unconditional logistic regression analysis showed an association between urinary zinc levels and the risk of T2DM as well, with an OR of 0.352 (95% CI: 0.212–0.585). The results of the multiplicative interaction model showed that the rs752760 T allele was associated with a significantly reduced risk of T2DM with moderate/low plasma zinc levels, with ORs of 0.340 (95% CI: 0.161–0.715) and 0.583 (95% CI: 0.346–0.981), respectively, and the rs752760 T allele was also associated with a significantly decreased risk of T2DM with moderate/low urinary zinc levels, with ORs of 0.358 (95% CI: 0.201–0.635) and 0.321 (95% CI: 0.183–0.562), respectively. CYP19A1 rs752760 T allele and moderate/low plasma/urinary zinc levels reduce the risk of T2DM.

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Data Availability

The datasets generated during and/or analyzed during the current study are not publicly available due to [REASON(S) WHY DATA ARE NOT PUBLIC] but are available from the corresponding authors on reasonable request.

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Acknowledgements

We are deeply appreciative of the participants in this study, and we thank all the staff for their support and assistance.

Funding

The study was supported by the National Natural Science Foundation of China (Grant Nos. 81960583, 81760577, 81560523, and 82260629), Major Science and Technology Projects in Guangxi (AA22096026), the Guangxi Science and Technology Development Project (Grant Nos. AD 17129003 and 18050005), the Guangxi Natural Science Foundation for Innovation Research Team (2019GXNSFGA245002), and the Guangxi Scholarship Fund of Guangxi Education Department of China.

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Author notes

  1. Xuexiu Wang, Yujian Liang, and Qiumei Liu contributed equally to this work.

Authors and Affiliations

  1. Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, China

    Xuexiu Wang, Yujian Liang, Qiumei Liu, Jiansheng Cai, Xu Tang, Shuzhen Liu, Junling Zhang, Min Xu, Chunmei Wei, Xiaoting Mo, Yanfei Wei, Yinxia Lin, Shenxiang Huang, Jian Qin & Zhiyong Zhang

  2. Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, China

    Jiansheng Cai

  3. Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin, China

    Tingyu Mai, Dechan Tan, Tingyu Luo, Ruoyu Gou & Zhiyong Zhang

  4. Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, China

    Jian Qin

  5. Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, China

    Jian Qin

  6. Key Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of Education, Guangxi Medical University, Nanning, China

    Jian Qin

  7. Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, Guilin Medical University, Guilin, China

    Zhiyong Zhang

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  1. Xuexiu Wang
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Contributions

Xuexiu Wang analyzed the data and wrote the manuscript. Yujian Liang, Qiumei Liu, and Jiansheng Cai revised the manuscript and gave suggestions. Xu Tang, Shuzhen Liu, Junling Zhang, Min Xu, Chunmei Wei, Xiaoting Mo, Yanfei Wei, Yinxia Lin, Shenxiang Huang, Tingyu Mai, Dechan Tan, Tingyu Luo, and Ruoyu Gou collected the relevant data. Jian Qin and Zhiyong Zhang put forward the study topic and provided advice on the writing of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Jian Qin or Zhiyong Zhang.

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Approval was obtained from the ethics committee of Guilin Medical University (No. 20180702–3). The procedures used in this study adhere to the tenets of the Declaration of Helsinki.

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Wang, X., Liang, Y., Liu, Q. et al. Association of CYP19A1 Gene, Plasma Zinc, and Urinary Zinc with the Risk of Type 2 Diabetes Mellitus in a Chinese Population. Biol Trace Elem Res 201, 4205–4215 (2023). https://doi.org/10.1007/s12011-022-03502-1

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