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Global Scientific Research Landscape on Aluminum Toxicology

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Abstract

This study aimed to identify the landscape of current aluminum toxicity based on knowledge mapping of the 100 most-cited articles on toxicological aspects of aluminum in biological organisms. The research was searched in the Web of Science Core Collection (WoS-CC) with publications between 1945 and 2022. Data regarding authorship, title, journal, year of publication, citation count, country, keywords, study design, and research hotspots were extracted and all elected articles were analyzed. Our results showed that among the articles selected, literature review and in vivo studies were the most common study designs. The USA and England were found as the countries with most publications. Alzheimer’s disease (AD), aluminum, and neurotoxicity were found as the most frequent keywords. The articles most cited in world literature suggested that aluminum exposure is associated with Alzheimer’s disease, Parkinson’s disease (PD), dialysis encephalopathy, amyotrophic lateral sclerosis, neurodegeneration changes, cognitive impairment, such as bone damage, oxidative alterations, and cytotoxicity.

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Data Availability

Data and material are available from the corresponding author on a reasonable request.

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Funding

RRL is a researcher from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and received grant under number 312275/2021–8. The APC was funded by Pró-Reitoria de Pesquisa e Pós-graduação from Federal University of Pará (PROPESP-UFPA).

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Authors and Affiliations

  1. Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa Street, n. 01, Guamá, Belém, Pará, 66075-110, Brazil

    Weslley Ferreira de Lima, Yago Gecy Sousa Né, Walessa Alana Bragança Aragão, Luciana Eiró-Quirino, Daiane Claydes Baia-da-Silva & Rafael Rodrigues Lima

  2. Faculty of Medicine, Institute of Anatomy, University of Belgrade, Belgrade, Serbia

    Ana Cirovic & Aleksandar Cirovic

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  1. Weslley Ferreira de Lima
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Weslley F. de Lima and Rafael R. Lima: conceptualization; Weslley F. de Lima, Yago G. S. Né, and Rafael R. Lima: data curation; formal analysis; Rafael R. Lima: funding acquisition; Weslley F. de Lima, Yago G. S. Né, and Walessa A. B. Aragão: investigation; Walessa A. B. Aragão, Luciana Eiró-Quirino, and Daiane C. Baia-da-Silva: methodology; Rafael R. Lima: project administration; resources; Daiane C. Baia-da-Silva: software and validation; Rafael R. Lima: supervision and visualization; Walessa A. B. Aragão and Luciana Eiró-Quirino: roles/writing—original draft; Ana Cirovic, Aleksandar Cirovic, and Rafael R. Lima: writing—review and editing. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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de Lima, W.F., Né, Y.G.S., Aragão, W.A.B. et al. Global Scientific Research Landscape on Aluminum Toxicology. Biol Trace Elem Res 201, 3210–3224 (2023). https://doi.org/10.1007/s12011-022-03427-9

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