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RELATIONSHIP BETWEEN SELENIUM NUTRITIONAL STATUS AND MARKERS OF LOW-GRADE CHRONIC INFLAMMATION IN OBESE WOMEN

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Abstract

Low-grade chronic inflammation is one of the main disorders that characterize adipose tissue dysfunction in obesity and is an important element in the pathogenesis of several comorbidities. In this context, selenium is an essential micronutrient that exerts important anti-inflammatory functions, and the role of selenium in controlling inflammation associated with obesity is not well defined. Thus, this study aimed to evaluate the relationship between markers of the nutritional status of selenium and low-grade chronic inflammation in obese women. This cross-sectional study included 81 women aged between 18 and 50 years, who were divided into two groups according to body mass index (BMI): the obesity group (n = 38) and normal weight group (n = 43). Selenium intake was assessed by 3-day diet records. The plasma, erythrocyte, and urinary selenium concentrations were determined using inductively coupled plasma optical emission spectrometry. The analysis of serum cytokines interleukin (IL)-8, IL-1β, IL-6, IL-10, and tumor necrosis factor alpha (TNFα) was performed using flow cytometry. The results of this study revealed that the obese women had higher dietary intake of selenium than eutrophic women. However, obese participants showed decreased selenium concentrations in plasma and erythrocytes, in parallel with increased concentrations of selenium in the urine. Regarding the inflammatory parameters, obese women exhibited higher concentrations of IL-6 and lower concentrations of the cytokines IL-8, IL-1β, and TNFα than eutrophic women. In the binary logistic regression analysis, erythrocyte selenium was considered an independent predictor of the serum concentrations of cytokine IL-8 in obese women, reflecting the anti-inflammatory action of this micronutrient.

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Data Availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

We would like to thank Editage (www.editage.com) for English language editing.

Funding

This study was partially supported by the National Coordination of High Education Personnel Formation Programs (CAPES – Brazil) (Finance Code 001) and the National Council for Scientific and Technologic Development (CNPq – Brazil).

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Authors and Affiliations

  1. Department of Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil

    Larissa Cristina Fontenelle, Mickael de Paiva Sousa, Loanne Rocha dos Santos, Bruna Emanuele Pereira Cardoso, Thayanne Gabryelle Visgueira de Sousa, Tamires da Cunha Soares, Stéfany Rodrigues de Sousa Melo, Jennifer Beatriz Silva Morais, Thaline Milany da Silva Dias & Dilina do Nascimento Marreiro

  2. Dexlab Diagnostic Medicine Integrated Center, Teresina, Piauí, Brazil

    Francisco Erasmo de Oliveira

  3. Department of Pharmacy, Federal University of Piauí, Teresina, Piauí, Brazil

    Débora Cavalcante Braz

  4. Department of Biochemistry and Pharmacology, Federal University of Piauí, Teresina, Piauí, Brazil

    João Marcelo de Castro e Sousa

  5. Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Piauí, Brazil

    Francisco Leonardo Torres-Leal

  6. Department of Nutrition, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Gilberto Simeone Henriques

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  1. Larissa Cristina Fontenelle
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Contributions

Conceptualization: LCF and DNM; Methodology: LCF, LRS, SRSM, JBSM and DNM; Resources: DNM, GSH, DCB, JMCS, FLTL, and FEO; Investigation: LCF, MPS, LRS, BEPC, TGVS, TCS, SRSM, JBSM, TMSD, FEO, and DCB; Formal analysis: LCF, DCB, and GSH;

Visualization and writing – original draft: LCF; Writing – review & editing: LCF and DNM; Project administration and Supervision: DNM.

Corresponding author

Correspondence to Larissa Cristina Fontenelle.

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Ethics Approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Federal University of Piauí (Date: 12 April 2017/No 2.014.100). Informed consent was obtained from all individual participants included in the study.

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The authors have no relevant financial or non-financial interests to disclose.

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Fontenelle, L.C., de Paiva Sousa, M., dos Santos, L.R. et al. RELATIONSHIP BETWEEN SELENIUM NUTRITIONAL STATUS AND MARKERS OF LOW-GRADE CHRONIC INFLAMMATION IN OBESE WOMEN. Biol Trace Elem Res 201, 663–676 (2023). https://doi.org/10.1007/s12011-022-03209-3

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