Abstract
Copper (Cu) is a vital microelement required for the optimum growth performance and wellbeing of aquatic animals. It contributed to various biological, physiological, and metabolic function in the entire body of the aquatic animals. Further, Cu is a cofactor for several enzymes involved in the antioxidation capacity and metalloenzyme formation. Some ingredients used for aquafeed formulation include sufficient amounts of Cu that can provide aquatic animals with their requirements. Nevertheless, in some cases, external Cu sources are needed to optimize the essential needs of aquatic animals. Inorganic, organic, and nano Cu forms are included in aquafeed and result in regulated physiological and biological functions. The addition of Cu should be added at particular doses considering the species, size, duration, and environmental conditions. Water-borne Cu level should also be considered as long as aquatic animals can obtain their requirements through gills to avoid overdosing and toxicity. Several studies reported the optimum doses of Cu required for optimal growth, productivity, and health status in several aquatic animals. This review article presents the up-to-date results of Cu-related studies in aquafeed. It also helps academia design further studies to better understand the border between Cu requirements and toxicity. Besides, planning for more studies involved in the understanding of the primary mode of action of Cu in aquatic animals’ entire bodies.
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References
Mustapha UF, Alhassan A-W, Jiang D-N, Li G-L (2021) Sustainable aquaculture development: a review on the roles of cloud computing, internet of things and artificial intelligence (CIA). Rev Aquac 13(4):2076–2091
Dawood MAO (2021) Nutritional immunity of fish intestines: important insights for sustainable aquaculture. Rev Aquac 13(1):642–663
Agboola JO, Øverland M, Skrede A, Hansen JØ (2021) Yeast as major protein-rich ingredient in aquafeeds: a review of the implications for aquaculture production. Rev Aquac 13(2):949–970
Dawood MAO, Koshio S (2020) Application of fermentation strategy in aquafeed for sustainable aquaculture. Rev Aquac 12(2):987–1002
Tacon AGJ (2020) Trends in global aquaculture and aquafeed production: 2000–2017. Reviews in Fisheries Science & Aquaculture 28(1):43–56
Antony Jesu Prabhu P, Schrama JW, Kaushik SJ (2016) Mineral requirements of fish: a systematic review. Rev Aquac 8(2):172–219
Watanabe T, Kiron V, Satoh S (1997) Trace minerals in fish nutrition. Aquaculture 151(1):185–207
Dawood MAO, Basuini MFE, Yilmaz S, Abdel-Latif HMR, Kari ZA, Abdul Razab MK, Ahmed HA, Alagawany M, Gewaily MS (2021) Selenium nanoparticles as a natural antioxidant and metabolic regulator in aquaculture: a review. Antioxidants 10(9):1364
Davis DA, Gatlin DM (1996) Dietary mineral requirements of fish and marine crustaceans. Rev Fish Sci 4(1):75–99
Dawood MAO, Alagawany M, Sewilam H (2021) The role of zinc microelement in aquaculture: a review. Biological Trace Element Research
Malhotra N, Ger T-R, Uapipatanakul B, Huang J-C, Chen KHC, Hsiao CD (2020) Review of copper and copper nanoparticle toxicity in fish. Nanomaterials 10(6):1126
Sabry MIE, Stino FKR, El-Ghany WAA (2021) Copper: benefits and risks for poultry, livestock, and fish production. Trop Anim Health Prod 53(5):487
Molina-Poveda C (2016) 4 - Nutrient requirements. In: Nates SF (ed) Aquafeed formulation. Academic Press, San Diego, pp 75–216
Tacon AGJ, Metian M (2008) Global overview on the use of fish meal and fish oil in industrially compounded aquafeeds: Trends and future prospects. Aquaculture 285(1):146–158
Masagounder K, Ramos S, Reimann I, Channarayapatna G (2016) 6 - Optimizing nutritional quality of aquafeeds. In: Nates SF (ed) Aquafeed Formulation. Academic Press, San Diego, pp 239–264
Scott A, Vadalasetty KP, Chwalibog A, Sawosz E (2018) Copper nanoparticles as an alternative feed additive in poultry diet: a review. Nanotechnol Rev 7(1):69–93
Bost M, Houdart S, Oberli M, Kalonji E, Huneau J-F, Margaritis I (2016) Dietary copper and human health: Current evidence and unresolved issues. J Trace Elem Med Biol 35:107–115
Bonham M, O’Connor JM, Hannigan BM, Strain JJ (2002) The immune system as a physiological indicator of marginal copper status? Br J Nutr 87(5):393–403
Uriu-Adams JY, Keen CL (2005) Copper, oxidative stress, and human health. Mol Aspects Med 26(4):268–298
Rowley DA (1998) Handbook of copper compounds and applications H. Wayne Richardson, Material and Manufacturing Process 13(3):479–480
Ghuglot R, Titus W, Agnihotri AS, Krishnakumar V, Krishnamoorthy G, Marimuthu N (2021) Stable copper nanoparticles as potential antibacterial agent against aquaculture pathogens and human fibroblast cell viability. Biocatal. Agric. Biotechnol 32:101932
Chari N, Felix L, Davoodbasha M, Sulaiman Ali A, Nooruddin T (2017) In vitro and in vivo antibiofilm effect of copper nanoparticles against aquaculture pathogens. Biocatal. Agric. Biotechnol 10(336):341
Hall AC, Young BW, Bremner I (1979) Intestinal metallothionein and the mutual antagonism between copper and zinc in the rat. J Inorg Biochem 11(1):57–66
Evans GW, Majors PF, Cornatzer WE (1970) Mechanism for cadmium and zinc antagonism of copper metabolism. Biochem Biophys Res Commun 40(5):1142–1148
Gatlin DM, Phillips HF, Torrans EL (1989) Effects of various levels of dietary copper and zinc on channel catfish. Aquaculture 76(1):127–134
Knox D, Cowey CB, Adron JW (1982) Effects of dietary copper and copper: zinc ratio on rainbow trout Salmo gairdneri. Aquaculture 27(2):111–119
Shi B, Lu J, Hu X, Betancor MB, Zhao M, Tocher DR, Zhou Q, Jiao L, Xu F, Jin M (2021) Dietary copper improves growth and regulates energy generation by mediating lipolysis and autophagy in hepatopancreas of Pacific white shrimp (Litopenaeus vannamei). Aquaculture 537:736505
Xu Z, Wang Y, Gul Y, Li Q, Song J, Hu M (2020) Effects of copper supplement on the immune function and blood-chemistry in adult Chinese horseshoe crab Tachypleus tridentatus. Aquaculture 515:734576
El-Sharawy ME, Mahmoud AA, Soliman AA, Amer AA, Mahmoud MA, Alkafafy M, Dawood MAO (2021) Studying the influence of copper on the growth behavior, antioxidative status, and histology of the intestine and liver of striped catfish (Pangasianodon hypophthalmus). Biological Trace Element Research
Gatlin DM, Wilson RP (1986) Dietary copper requirement of fingerling channel catfish. Aquaculture 54(4):277–285
Lee M-H, Shiau S-Y (2002) Dietary copper requirement of juvenile grass shrimp, Penaeus monodon, and effects on non-specific immune responses. Fish Shellfish Immunol 13(4):259–270
Murai T, Andrews JW, Smith RG (1981) Effects of dietary copper on channel catfish. Aquaculture 22:353–357
Abdel-Hameid N-AH, Zehra S, Khan MA (2017) Dietary copper requirement of fingerling Channa punctatus (Bloch) based on growth, feed conversion, blood parameters and whole body copper concentration. Aquac Res 48(6):2787–2797
Farmer BD, Beck BH, Mitchell AJ, Rawles SD, Straus DL (2017) Dietary copper effects survival of channel catfish challenged with Flavobacterium columnare. Aquac Res 48(4):1751–1758
Berntssen MHG, Lundebye AK, Maage A (1999) Effects of elevated dietary copper concentrations on growth, feed utilisation and nutritional status of Atlantic salmon (Salmo salar L.) fry. Aquaculture 174(1):167–181
Lin Y-H, Shie Y-Y, Shiau S-Y (2008) Dietary copper requirements of juvenile grouper Epinephelus malabaricus. Aquaculture 274(1):161–165
Shiau SY, Ning YC (2003) Estimation of dietary copper requirements of juvenile tilapia, Oreochromis niloticus * O. aureus. Animal Science 77(2):287–292
Wang W, Mai K, Zhang W, Ai Q, Yao C, Li H, Liufu Z (2009) Effects of dietary copper on survival, growth and immune response of juvenile abalone Haliotis discus hannai Ino. Aquaculture 297(1):122–127
Tan XY, Luo Z, Liu X, Xie CX (2011) Dietary copper requirement of juvenile yellow catfish Pelteobagrus fulvidraco. Aquac Nutr 17(2):170–176
Chen Q-L, Luo Z, Wu K, Huang C, Zhuo M-Q, Song Y-F, Hu W (2015) Differential effects of dietary copper deficiency and excess on lipid metabolism in yellow catfish Pelteobagrus fulvidraco. Comp Biochem Physiol B: Biochem Mol Biol 184:19–28
Sun S, Qin J, Yu N, Ge X, Jiang H, Chen L (2013) Effect of dietary copper on the growth performance, non-specific immunity and resistance to Aeromonas hydrophila of juvenile Chinese mitten crab Eriocheir sinensis. Fish Shellfish Immunol 34(5):1195–1201
Tang QQ, Feng L, Jiang WD, Liu Y, Jiang J, Li SH, Kuang SY, Tang L, Zhou XQ (2013) Effects of dietary copper on growth, digestive, and brush border enzyme activities and antioxidant defense of hepatopancreas and intestine for young grass carp (Ctenopharyngodon idella). Biol Trace Elem Res 155(3):370–380
Cao J, Miao X, Xu W, Li J, Zhang W, Mai K (2014) Dietary copper requirements of juvenile large yellow croaker Larimichthys croceus. Aquaculture 432:346–350
Meng F, Li M, Tao Z, Yuan L, Song M, Ren Q, Xin X, Meng Q, Wang R (2016) Effect of high dietary copper on growth, antioxidant and lipid metabolism enzymes of juvenile larger yellow croaker Larimichthys croceus. Aquaculture Reports 3:131–135
Mohseni M, Pourkazemi M, Bai SC (2014) Effects of dietary inorganic copper on growth performance and immune responses of juvenile beluga Husohuso. Aquac Nutr 20(5):547–556
Damasceno FM, Fleuri LF, Sartori MMP, Amorim RL, Pezzato LE, da Silva RL, Carvalho PLPF, Barros MM (2016) Effect of dietary inorganic copper on growth performance and hematological profile of Nile tilapia subjected to heat-induced stress. Aquaculture 454:257–264
Luo F, Wang W, Chen M, Zheng Z, Zeng D, Hasan M, Fu Z, Shu X (2020) Synthesis and efficacy of the N-carbamoyl-methionine Copper on the growth performance, tissue mineralization, immunity, and enzymatic antioxidant capacity of nile tilapia (Oreochromis niloticus). ACS Omega 5(35):22578–22586
Wang H, Li E, Zhu H, Du Z, Qin J, Chen L (2016) Dietary copper requirement of juvenile Russian sturgeon Acipenser gueldenstaedtii. Aquaculture 454:118–124
Wang H, Zhu H, Wang X, Li E, Du Z, Qin J, Chen L (2018) Comparison of copper bioavailability in copper-methionine, nano-copper oxide and copper sulfate additives in the diet of Russian sturgeon Acipenser gueldenstaedtii. Aquaculture 482:146–154
Moazenzadeh K, RajabiIslami H, Zamini A, Soltani M (2020) Effect of dietary inorganic copper on growth performance and some hematological indices of Siberian sturgeon Acipenserbaerii Juveniles. N. Am. J. Aquac 82(2):200–207
Moazenzadeh K, RajabiIslami H, Zamini A, Soltani M (2020) Quantitative dietary copper requirement of juvenile Siberian sturgeon, Acipenser baerii, and effects on muscle composition and some enzymatic activities. Aquac. Nutr 26(4):1108–1118
Domínguez D, Sarmiento P, Sehnine Z, Castro P, Robaina L, Fontanillas R, Prabhu PAJ, Izquierdo M (2019) Effects of copper levels in diets high in plant ingredients on gilthead sea bream (Sparus aurata) fingerlings. Aquaculture 507:466–474
Chen K, Yamamoto FY, Gatlin Iii DM (2020) Effects of inorganic and organic dietary copper supplementation on growth performance and tissue composition for juvenile red drum (Sciaenops ocellatus L.). Aquac. Nutr 26(3):820–827
Song J, Li L-Y, Chen B-B, Shan L-L, Yuan S-Y, Yu H-R (2021) Dietary copper requirements of postlarval coho salmon (Oncorhynchus kisutch). Aquaculture Nutrition
Zafar N, Khan MA (2020) Dietary copper requirement of fingerling Heteropneustes fossilis for formulating copper-balanced commercial feeds. Aquac Nutr 26(2):248–260
Liang H, Ji K, Ge X, Mi H, Xi B, Ren M (2020) Effects of dietary copper on growth, antioxidant capacity and immune responses of juvenile blunt snout bream (Megalobramaamblycephala) as evidenced by pathological examination. Aquac Rep 17:100296
Shao X-P, Liu W-B, Lu K-L, Xu W-N, Zhang W-W, Wang Y, Zhu J (2012) Effects of tribasic copper chloride on growth, copper status, antioxidant activities, immune responses and intestinal microflora of blunt snout bream (Megalobrama amblycephala) fed practical diets. Aquaculture 338–341:154–159
Davis DA, Lawrence AL, Gatlin Iii D (1993) Dietary copper requirement of Penaeusvannamei. NIPPON SUISAN GAKKAISHI 59(1):117–122
Zhou Y, Zhang D, Peatman E, Rhodes MA, Liu J, Davis DA (2017) Effects of various levels of dietary copper supplementation with copper sulfate and copper hydroxychloride on Pacific white shrimp Litopenaeus vannamei performance and microbial communities. Aquaculture 476:94–105
Zhou Y, Allen Davis D, Rhodes MA (2014) Comparative evaluation of copper sulfate and tribasic copper chloride on growth performance and tissue response in Pacific white shrimp Litopenaeusvannamei fed practical diets. Aquaculture 434:411–417
Musharraf M, Khan MA (2022) Estimation of dietary copper requirement of fingerling Indian major carp, Labeorohita (Hamilton). Aquaculture 549:737742
Bharadwaj AS, Patnaik S, Browdy CL, Lawrence AL (2014) Comparative evaluation of an inorganic and a commercial chelated copper source in Pacific white shrimp Litopenaeus vannamei (Boone) fed diets containing phytic acid. Aquaculture 422–423:63–68
Lin Y-H, Shih C-C, Kent M, Shiau S-Y (2010) Dietary copper requirement reevaluation for juvenile grouper, Epinephelus malabaricus, with an organic copper source. Aquaculture 310(1):173–177
Shao X-P, Liu W-B, Xu W-N, Lu K-L, Xia W, Jiang Y-Y (2010) Effects of dietary copper sources and levels on performance, copper status, plasma antioxidant activities and relative copper bioavailability in Carassius auratus gibelio. Aquaculture 308(1):60–65
Mohseni M, Park G-H, Lee J-H, Okorie OE, Browdy C, Bharadwaj A, Bai SC (2012) Evaluation of toxicity of dietary chelated copper in juvenile olive flounder, Paralichthys olivaceus, Based on growth and tissue copper concentration. J World Aquaculture Soc 43(4):548–559
Wang L-M, Wang J, Bharadwaj AS, Xue M, Qin Y-C, Wu X-F, Zheng Y-H, Han F (2015) Effects of dietary copper sources on growth, tissue copper accumulation and physiological responses of Japanese sea bass (Lateolabrax japonicus) (Cuvier, 1828) fed semipurified or practical diets. Aquac Res 46(7):1619–1627
Yuan Y, Jin M, Luo J, Xiong J, Ward TL, Ji F, Xu G, Sun M, Zhou Q (2019) Effects of different dietary copper sources on the growth and intestinal microbial communities of Pacific white shrimp (Litopenaeus vannamei). Aquac Nutr 25(4):828–840
Shi B, Yuan Y, Jin M, Betancor MB, Tocher DR, Jiao L, Song D, Zhou Q (2021) Transcriptomic and physiological analyses of hepatopancreas reveal the key metabolic changes in response to dietary copper level in Pacific white shrimp Litopenaeusvannamei. Aquaculture 532:736060
Katya K, Lee S, Yun H, Dagoberto S, Browdy CL, Vazquez-Anon M, Bai SC (2016) Efficacy of inorganic and chelated trace minerals (Cu, Zn and Mn) premix sources in Pacific white shrimp, Litopenaeus vannamei (Boone) fed plant protein based diets. Aquaculture 459:117–123
Swain PS, Rao SBN, Rajendran D, Dominic G, Selvaraju S (2016) Nano zinc, an alternative to conventional zinc as animal feed supplement: a review. Animal Nutrition 2(3):134–141
Konkol D, Wojnarowski K (2018) The use of nanominerals in animal nutrition as a way to improve the composition and quality of animal products. J Chem 2018:5927058
El Basuini MF, El-Hais AM, Dawood MAO, Abou-Zeid AE-S, El-Damrawy SZ, Khalafalla MMELS, Koshio S, Ishikawa M, Dossou S (2016) Effect of different levels of dietary copper nanoparticles and copper sulfate on growth performance, blood biochemical profiles, antioxidant status and immune response of red sea bream (Pagrus major). Aquaculture 455:32–40
Dawood MAO, Eweedah NM, Moustafa EM, El-Sharawy ME, Soliman AA, Amer AA, Atia MH (2020) Copper Nanoparticles mitigate the growth, immunity, and oxidation resistance in common carp (Cyprinus carpio). Biol Trace Elem Res 198(1):283–292
Afshari A, Sourinejad I, Gharaei A, Johari SA, Ghasemi Z (2021) The effects of diet supplementation with inorganic and nanoparticulate iron and copper on growth performance, blood biochemical parameters, antioxidant response and immune function of snow trout Schizothoraxzarudnyi (Nikolskii, 1897). Aquaculture 539:736638
Muralisankar T, SaravanaBhavan P, Radhakrishnan S, Seenivasan C, Srinivasan V (2016) The effect of copper nanoparticles supplementation on freshwater prawn Macrobrachiumrosenbergii post larvae. J Trace Elem Med Biol 34(39):49
Delavari NM, Gharaei A, Mirdar HJ, Davari A, Rastiannasab A (2021) Modulatory effect of dietary copper nanoparticles and vitamin C supplementations on growth performance, hematological and immune parameters, oxidative status, histology, and disease resistance against Yersinia ruckeri in rainbow trout (Oncorhynchus mykiss). Fish Physiology and Biochemistry
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Dawood, M.A.O. Dietary Copper Requirements for Aquatic Animals: A Review. Biol Trace Elem Res 200, 5273–5282 (2022). https://doi.org/10.1007/s12011-021-03079-1
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DOI: https://doi.org/10.1007/s12011-021-03079-1