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Novel Gold Nanoparticles: Green Synthesis with Eryngium thyrsoideum Boiss Extract, Characterization, and In Vivo Investigations on Inflammatory Gene Expression and Biochemical Parameters in Type 2 Diabetic Rats

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Abstract

In this work, we synthesized and reported gold nanoparticles (Au NPs) with Eryngium thyrsoideum Boiss plant extract for first time. The plant extract has important effect as reducing and stabilizing agent for preparation of Au nanoparticles. The synthesized gold nanoparticles were characterized with FT-IR, UV–vis, XRD, SEM, and TEM analyses. All analyses confirmed successful synthesis of gold nanoparticles with high purity. The antidiabetic activity of synthesized Au NPs was investigated on type 2 diabetic rats by studying their influences on serum biochemical parameters and inflammatory markers. Obtained results revealed that hepatic enzymes, TNF-α, and interleukin-6 of diabetic rats receiving gold nanoparticles decreased in compare with healthy control rats. As inflammatory markers are main reasons for hyperglycemic-induced insulin resistance in diabetes, Au NPs have a possible option for management of the diabetes-related complication via their potent anti-inflammatory and hypoglycemic effects.

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Data Availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

References

  1. Nasaruddin RR, Chen T, Yao Q, Zang Sh, Xi J (2021) Toward greener synthesis of gold nanomaterials: from biological to biomimetic synthesis. Coord Chem Rev 426:213540

    Article  CAS  Google Scholar 

  2. Chen X, Xue Zh, Ji J, Wang D, Shi G, Zhao L, Feng Sh (2021) Hedysarum polysaccharides mediated green synthesis of gold nanoparticles and study of its characteristic, analytical merit, catalytic activity. Mater Res Bull 133:111070

    Article  CAS  Google Scholar 

  3. Samantha Sibuyi R, Thipe VCT, Panjtan-Amiri K, Meyer M, Katti KV (2021) Green synthesis of gold nanoparticles using Acai berry and Elderberry extracts and investigation of their effect on prostate and pancreatic cancer cells. Nanobiomedicine 8:1–8

    Google Scholar 

  4. Jyoti K, Baunthiyal M, Singh A (2016) Characterization of silver nanoparticles synthesized using Urtica dioica Linn. leaves and their synergistic effects with antibiotics. J Res Appl Sci 9:217–227

    CAS  Google Scholar 

  5. Zhang XD, Wu HY, Wang YY, Chang JH, Zhai ZB, Meng AM, Liu PX, Zhang LA, Fan FY (2010) Toxicologic effects of gold nanoparticles in vivo by different administration routes. Int J Nanomedicine 5:771–781

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Bahamonde J, Brenseke B, Chan MY, Kent RD, Vikesland PJ, Prater MR (2018) Gold nanoparticle toxicity in mice and rats: species differences. Toxicol Pathol 46(4):431–443

    Article  CAS  PubMed  Google Scholar 

  7. ManiKanth SB, Kalishwaralal K, Sriram M, Kumar Pandian SR, Youn H-S, Eom S, Gurunathan S (2010) Anti-oxidant effect of gold nanoparticles restrains hyperglycemic conditions in diabetic mice. J Nanobiotechnol 8:16

    Article  Google Scholar 

  8. Yang L, Kuang H, Zhang W, Aguilar ZP, Wei H, Xu H (2017) Comparisons of the biodistribution and toxicological examinations after repeated intravenous administration of silver and gold nanoparticles in mice. Sci Rep 7(3303):1–12

    Google Scholar 

  9. Najafi F, Ghasemian N, Safari M, Salami-Kalajahi M (2021) Poly (propylene imine) dendrimer as reducing agent for chloroauric acid to fabricate and stabilize gold nanoparticles. J Phys Chem Solids 148:109682

    Article  CAS  Google Scholar 

  10. Fuentes-García JA, Santoyo-Salzar J, Rangel-Cortes E, Goya GF, Cardozo-Mata V, Pescador-Rojas JA (2021) Effect of ultrasonic irradiation power on sonochemical synthesis of gold nano-particles. Ultrason Sonochem 70:105274

    Article  PubMed  Google Scholar 

  11. Edrees HM, Elbehiry A, Elmosaad YM (2017) Hypoglycemic and anti-inflammatory effect of gold nanoparticles in streptozotocin-induced type 1 diabetes in experimental rats. International J Diabetes Res 6(1):16–23

    Google Scholar 

  12. Selim ME, Abd-Elhakim YM, Al-Ayadhi LY (2015) Pancreatic response to gold nanoparticles includes decrease of oxidative stress and inflammation in autistic diabetic model. Cell Physiol Biochem 35(2):586–600

    Article  CAS  PubMed  Google Scholar 

  13. Chen H, Ng JPM, Bishop DP, Milthorpe BK, Valenzuela SM (2018) Gold nanoparticles as cell regulators: beneficial effects of gold nanoparticles on the metabolic profile of mice with pre-existing obesity. J Nanobiotechnol 16(1):88

    Article  CAS  Google Scholar 

  14. GhajariehSepanlou M, MirabzadehArdakani M, Hajimahmoodi M, Sadrai S, Amin Gh-R, Sadeghi N, Lamardi SNS (2019) Tradi Med Res 4(3):148–159

    Google Scholar 

  15. Peña-Montes DJ, Huerta-Cervantes M, Ríos-Silva M, Trujillo X, Huerta M, Noriega-Cisneros R, Salgado-Garciglia R, Saavedra-Molina A (2019) Protective effect of the hexanic extract of Eryngium carlinae inflorescences in vitro, in yeast, and in streptozotocin-induced diabetic male rats. Antioxidants (Basel) 8(3):1–12

    Google Scholar 

  16. Akash MSH, Rehman K, Liaqat A (2018) Tumor necrosis factor-alpha: role in development of insulin resistance and pathogenesis of type 2 diabetes mellitus. J Cell Biochem 119(1):105–110

    Article  CAS  PubMed  Google Scholar 

  17. Yung JHM, Giacca A (2020) Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2. Diabetes Cells 9(3):706

    CAS  Google Scholar 

  18. Tsalamandris S, Antonopoulos AS, Oikonomou E, Papamikroulis G-A, Vogiatzi G, Papaioannou S, Deftereos S, Tousoulis D (2019) The role of inflammation in diabetes: current concepts and future perspectives. Eur Cardiol 14(1):50–59

    Article  PubMed  PubMed Central  Google Scholar 

  19. Mahmoudi F, Mahmoudi F, Haghighat Gollo Kh, Amini MM (2021) Biosynthesis of novel silver nanoparticles using Eryngium thyrsoideum Boiss extract and comparison of their antidiabetic activity with chemical synthesized silver nanoparticles in diabetic rats. Biol Trace Elem Res 199(5):1967–1978

    Article  CAS  PubMed  Google Scholar 

  20. Lee KX, Shameli K, Yew YP, Teow S-Y, Jahangirian H, Rafiee-Moghaddam R, Webster TJ (2020) Recent developments in the facile bio-synthesis of gold nanoparticles (AuNPs) and their biomedical applications. Int J Nanomed 15:275–300

    Article  CAS  Google Scholar 

  21. Khan ShA, Shahid S, Lee Ch-S (2020) Green synthesis of gold and silver nanoparticles using leaf extract of Clerodendrum inerme; characterization, antimicrobial, and antioxidant activities. Biomolecules 10(6):835

    Article  CAS  PubMed Central  Google Scholar 

  22. Wen W, Lin Y, Ti Zh (2019) Antidiabetic, antihyperlipidemic, antioxidant, anti-inflammatory activities of ethanolic seed extract of Annona reticulata L. in streptozotocin induced diabetic rats. Front Endocrinol (Lausanne) 10:716

    Article  Google Scholar 

  23. Potarniche AV, Dreanca AL, Sarpataki O, Sevastre B, Marcus L (2018) Experimental model of streptozotocin-nicotinamide induced diabetes mellitus type II in sprague-dawley rats: step by step protocol and the encountered issues. Rev Rom Med Vet 28(2):22–26

    Google Scholar 

  24. Haghighat Kh, Mahmoudi F, Bayrami A, Zahri S (2020) Influences of L-DOPA and blocking dopamine receptors on aromatase gene expression and serum concentration of LH in polycystic ovary syndrome model rats. J fasa Univ Med Sci 10(3):2448–2455

    CAS  Google Scholar 

  25. Vijayan R, Joseph S, Mathew B (2018) Indigofera tinctoria leaf extract mediated green synthesis of silver and gold nanoparticles and assessment of their anticancer, antimicrobial, antioxidant and catalytic properties. Artif Cell, Nanomed B 46(4):861–871

    Article  CAS  Google Scholar 

  26. Lee KX, Shameli K, Miyake M, Kuwano N, Khairudin NB, Mohamad ShE, Yew YP (2016) Green synthesis of gold nanoparticles using aqueous extract of Garcinia mangostana fruit peels. J Nanomater Article ID 8489094

  27. Depciuch J, Stec M, Kandler M, Baran J, Parlinska-Wojtan M (2020) From spherical to bone-shaped gold nanoparticles-time factor in the formation of Au NPs, their optical and photothermal properties. Photodiagn Photodyn Ther 30:101670

    Article  CAS  Google Scholar 

  28. Singh Priyanka, Kim YeonJu, Wang Chao, RamyaMathiyalagan DCh, Yang, (2016) The development of a green approach for the biosynthesis of silver and gold nanoparticles by using Panax ginseng root extract, and their biological applications. Artif Cells Nanomed Biotechnol 44(4):1150–1157

    CAS  PubMed  Google Scholar 

  29. Oguntibeju O (2019) Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links. Int J Physiol Pathophysiol Pharmacol 11(3):45–63

    CAS  PubMed  PubMed Central  Google Scholar 

  30. Agarwal H, Nakara A, Shanmugam VK (2019) Anti-inflammatory mechanism of various metal and metal oxide nanoparticles synthesized using plant extracts: a review. Biomed Pharmacother 109:2561–2572

    Article  CAS  PubMed  Google Scholar 

  31. Kim MJ, Rehman ShU, Ul Amin F, Kim MO (2017) Enhanced neuroprotection of anthocyanin-loaded PEG-gold nanoparticles against Aβ-induced neuroinflammation and neurodegeneration via the NF- K B /JNK/GSK3β signaling pathway. Nanomed 13(8):2533–2544

    Article  CAS  Google Scholar 

  32. Burgos-Morón E, Abad-Jiménez Z, de Marañón AM, Iannantuoni F, Escribano-López I, López-Domènech S, Salom Ch, Jover A, Mora V, Roldan I, Solá E, Rocha M, Víctor VM (2019) Relationship between oxidative stress, ER stress, and inflammation in type 2 diabetes: the battle continues. J Clin Med 8(9):1385

    Article  PubMed Central  Google Scholar 

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Acknowledgements

The authors thank University of Mohaghegh Ardabili and Shahid Beheshti University for support of this work.

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Authors and Affiliations

  1. Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, 5619913131, Ardabil, Iran

    Fariba Mahmoudi & Khadijeh Haghighat Gollo

  2. Department of Chemistry, Shahid Beheshti University, G. C., 1983963113, Tehran, Iran

    Farzaneh Mahmoudi & Mostafa M. Amini

Authors
  1. Fariba Mahmoudi
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  2. Farzaneh Mahmoudi
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  3. Khadijeh Haghighat Gollo
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  4. Mostafa M. Amini
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Contributions

Fariba Mahmoudi: project administration; supervision. Farzaneh Mahmoudi: formal analysis; investigation; validation; visualization. Khadijeh Haghighat Gollo: formal analysis; investigation; validation. Mostafa M. Amini: supervision; validation.

Corresponding authors

Correspondence to Fariba Mahmoudi or Farzaneh Mahmoudi.

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Ethics Approval and Consent to Participate

This study was approved by the Research and Ethics Committee of Ardabil University of Medical Sciences (IR.ARUMS.REC.1399.354), and relevant descriptions were provided with respect to the aims of the research.

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The authors declare no competing interests.

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Mahmoudi, F., Mahmoudi, F., Gollo, K.H. et al. Novel Gold Nanoparticles: Green Synthesis with Eryngium thyrsoideum Boiss Extract, Characterization, and In Vivo Investigations on Inflammatory Gene Expression and Biochemical Parameters in Type 2 Diabetic Rats. Biol Trace Elem Res 200, 2223–2232 (2022). https://doi.org/10.1007/s12011-021-02819-7

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  • DOI: https://doi.org/10.1007/s12011-021-02819-7

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