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The Effect of Oral Magnesium Supplementation on Inflammatory Biomarkers in Adults: A Comprehensive Systematic Review and Dose–response Meta-analysis of Randomized Clinical Trials

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Abstract

This is a comprehensive systematic review and dose–response meta-analysis evaluating the effects of oral magnesium supplementation on inflammatory biomarkers including C-reactive protein (CRP), interleukin‐6 (IL‐6), and tumor necrosis factor-alpha (TNF‐α) among adults. The major databases including PubMed, Web of Science, Embase, and Google Scholar were searched for relevant publications until December 14, 2020, using appropriate keywords. The Cochrane Collaboration tool was used to assess the quality of each study. We also performed a subgroup analysis to identify probable sources of heterogeneity. A total of 18 studies with 927 participants fulfilled the eligibility criteria and included in this meta-analysis. Our results indicate that the supplementation with magnesium had no statistically significant effect on serum concentrations of CRP (WMD, − 0.49; 95% CI, − 1.72 to 0.75 mg/L; P = 0.44), IL-6 (WMD, − 0.03; 95% CI, − 0.40 to 0.33 pg/mL; P = 0.86), and TNF‐α (WMD, 0.12; 95% CI, − 0.08 to 0.31 pg/mL; P = 0.24) compared with controls. In addition, based on dose–response assessment, no significant non-linear association was found between magnesium supplementation dosage or duration on serum CRP and IL-6 concentrations. The findings of the present systematic review and meta-analysis did not support the notion that oral magnesium supplementation could have favorable effects on CRP, IL-6, and TNF-α in the adult population.

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Authors and Affiliations

  1. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

    Sepide Talebi & Hamed Mohammadi

  2. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Maryam Miraghajani

  3. The Early Life Research Unit, Academic Division of Child Health, Obstetrics and Gynaecology, and Nottingham Digestive Disease Centre and Biomedical Research Centre, The School of Medicine, University of Nottingham, Nottingham, NG7 2UH, UK

    Maryam Miraghajani

  4. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    Reza Hosseini

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  1. Sepide Talebi
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  2. Maryam Miraghajani
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  3. Reza Hosseini
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  4. Hamed Mohammadi
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Sepide Talebi and Hamed Mohammadi contributed to the conception of research, searched databases and data extraction, and performed statistical analysis. Sepide Talebi and Maryam Miraghajani wrote the manuscript. Hamed Mohammadi and Reza Hosseini contributed to the revision of the manuscript. All authors approved the final manuscript for submission.

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Correspondence to Hamed Mohammadi.

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Talebi, S., Miraghajani, M., Hosseini, R. et al. The Effect of Oral Magnesium Supplementation on Inflammatory Biomarkers in Adults: A Comprehensive Systematic Review and Dose–response Meta-analysis of Randomized Clinical Trials. Biol Trace Elem Res 200, 1538–1550 (2022). https://doi.org/10.1007/s12011-021-02783-2

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