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Effect of Resveratrol, l-Carnitine, and Aromatic Amino Acid Supplements on the Trace Element Content in the Organs of Mice with Dietary-Induced Obesity

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Abstract

Given environmental contamination with toxic metals, diets that promote the elimination of these metals from the body of individuals, including those suffering from obesity, are urgently needed. The aim of this study was to determine the effects of supplementation with resveratrol (Res), l-carnitine (l-Car), tyrosine (Tyr), and tryptophan (Trp) on the content of trace elements in the organs of mice. DBA/2J mice and DBCB tetrahybrid mice received diets high in carbohydrate and fat supplemented with Res, l-Car, Tyr, or Trp for 65 days. In the liver, kidneys, and brain, the contents of 18 elements, including Al, As, Cu, Fe, Mn, Pb, Se, and Zn, were determined by inductively coupled plasma mass spectrometry. Res, l-Car, Tyr, and Trp had minimal or no effect on the essential elements (Fe, Mg, Cu, Zn, Se) in all organs studied. The Mn content notably increased in the organs of mice consuming l-Car and Trp. Mn accumulation was stimulated by Res in organs exclusively in DBCB mice and by Tyr exclusively in livers and brains of DBA/2J mice. Al levels were significantly reduced by l-Car and Trp in all organs of the mice, by Res in only DBCB mice, and by Tyr in only kidneys and livers of DBA/2J mice. In addition, l-Car and Trp decreased Pb accumulation in most organs of mice. Res and Tyr also inhibited Pb accumulation in some cases. Thus, the studied supplements affected the metabolism of trace elements, which may contribute to dietary treatments for obese individuals.

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Data Availability

The datasets generated during the current study are available from the corresponding author on reasonable request by email.

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Funding

The work was supported by a grant from the Russian Scientific Foundation: No. 17-16-01043, “Search for effector units of metabolism regulated by alimentary factors in obesity or the development of innovative specialized food.”

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Authors and Affiliations

  1. Federal Research Centre of Nutrition, Biotechnology and Food Safety, Ust’insky proezd 2/14, Moscow, 109240, Russia

    Antonina A. Shumakova, Vladimir A. Shipelin, E. V. Leontyeva & Ivan V. Gmoshinski

  2. Plekhanov Russian University of Economics, Moscow, 115093, Russia

    Vladimir A. Shipelin

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  1. Antonina A. Shumakova
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  2. Vladimir A. Shipelin
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  3. E. V. Leontyeva
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  4. Ivan V. Gmoshinski
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Contributions

A.A. Shumakova: methodology, data curation, visualization, supervision, validation.

V.A. Shipelin: writing—original draft, supervision, project administration.

E.V. Leontyeva: investigation, resources.

I.V. Gmoshinski: conceptualization, formal analysis, writing—review and editing, supervision, funding acquisition.

Corresponding author

Correspondence to Ivan V. Gmoshinski.

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Ethics Approval

The design of the experiment was approved by the Ethics Committee of the Federal Research Centre of Nutrition and Biotechnology (protocol no. 4 of 04/20/2017).

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The authors declare no competing interests.

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Shumakova, A.A., Shipelin, V.A., Leontyeva, E.V. et al. Effect of Resveratrol, l-Carnitine, and Aromatic Amino Acid Supplements on the Trace Element Content in the Organs of Mice with Dietary-Induced Obesity. Biol Trace Elem Res 200, 281–297 (2022). https://doi.org/10.1007/s12011-021-02642-0

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