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Effects of Supranutritional Selenium Nanoparticles on Immune and Antioxidant Capacity in Sprague-Dawley Rats

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Abstract

The present study was conducted to investigate the effects of supranutritional selenium nanoparticles (SeNPs) on immune and antioxidant capacity in rats. Forty male Sprague-Dawley (SD) rats were randomly divided into four groups and given intragastric administration of SeNPs at doses of 0, 0.2, 0.4, and 0.8 mg Se/kg BW, respectively, for 2 weeks. Serum immune parameters, serum and organic tissues (liver, heart, kidney) antioxidant indices, and liver mRNA expression of glutathione peroxidase 1 (GPx1) and glutathione peroxidase 4 (GPx4) were examined. The results showed that supranutritional doses of 0.4 and 0.8 mg Se/kg BW SeNPs promoted the immune responses in serum. SeNPs administration improved antioxidant capacity in the liver and kidney, and the best improvement on antioxidant capacity was found in the kidney. Furthermore, intragastric administration of SeNPs upregulated mRNA expression of GPx1 and GPx4 in the liver. The results obtained indicated that SeNPs administration at supranutritional levels had beneficial effects on immune and antioxidant capacity and supplemental SeNPs at dose of 0.4 mg Se/kg BW exhibited the best response in SD rats.

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Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgments

We acknowledge financial support from the Three Agricultural and Six Party Research Cooperation Project of Zhejiang Province (CTZBF180706LWZ-SNY1) and the Science and Technology Research Project of Education Department of Jiangxi Province (171342).

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Authors and Affiliations

  1. Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Science, Zhejiang University, Hangzhou, 310058, China

    Yuyue Jin, Lujie Liu, Wenjing Tao, Geng Wang, Wanjing Sun, Xun Pei, Zhiping Xiao, Haidong Wang & Minqi Wang

  2. Department of Animal Science, Jiangxi Biotech Vocational College, 608 Nanlian Road, Nanchang, 330200, Jiangxi, People’s Republic of China

    Yudan He

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  1. Yuyue Jin
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Jin, Y., He, Y., Liu, L. et al. Effects of Supranutritional Selenium Nanoparticles on Immune and Antioxidant Capacity in Sprague-Dawley Rats. Biol Trace Elem Res 199, 4666–4674 (2021). https://doi.org/10.1007/s12011-021-02601-9

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