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Zinc Supplementation Restores Altered Biochemical Parameters in Stomach Tissue of STZ Diabetic Rats

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Abstract

The stomach is among the organs grossly affected organ by diabetic complications. The present study was aimed at investigating the protective role of zinc on stomach of streptozotocin (STZ)-induced diabetes mellitus. Female Swiss albino rats were divided in four experimental groups: Group I, control; group II, control + zinc sulfate; group III, STZ-induced diabetic animals; and group IV, STZ-diabetic + zinc sulfate. Diabetes was induced by intraperitoneal injection of STZ, at a dose of 65 mg/kg body weight. Zinc sulfate (100 mg/kg body weight) was given daily by gavage for 60 days to groups II and IV. At the end of the experiment, the rats were sacrificed, and the tissues were taken. In the diabetic group, hexose, hexosamine, fucose, and sialic acid levels, as well as tissue factor, adenosine deaminase, carbonic anhydrase, xanthine oxidase, lactate dehydrogenase, prolidase activities, advanced oxidized protein products, homocysteine, and TNF-α levels were increased in the stomach tissue homogenates. Whereas, catalase, superoxide dismutase, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, paraoxonase, and aryl esterase activities were decreased in the diabetic group. The administration of zinc reversed all the deformities. These findings suggest that zinc has protective role in ameliorating several mechanisms of STZ-induced diabetic stomach injury.

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Funding

This work was supported by Scientific Research Projects Coordination Unit of Istanbul University and Istanbul University-Cerrahpaşa. Project number: BEK-2016-22420 and FYO-2019-32112.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Engineering, Biochemistry Division, Istanbul University-Cerrahpasa, Avcilar, 34320, Istanbul, Turkey

    Ismet Burcu Turkyilmaz, Bertan Boran Bayrak, Ozlem Sacan, Ozgur Mutlu & Refiye Yanardag

  2. Department of Biochemistry, Faculty of Pharmacy, Istanbul University, 34116, Istanbul, Turkey

    Nuriye Akev

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Turkyilmaz, I.B., Bayrak, B.B., Sacan, O. et al. Zinc Supplementation Restores Altered Biochemical Parameters in Stomach Tissue of STZ Diabetic Rats. Biol Trace Elem Res 199, 2259–2265 (2021). https://doi.org/10.1007/s12011-020-02352-z

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