Abstract
Exposures to toxic trace elements and deficiencies of essential elements during pregnancy are associated to various birth complications. Assessment of the trace elements in pregnant women living in specific areas is important for biomonitoring. A total of 196 healthy pregnant women absent of pregnancy complications living in Wuhan of China and 210 healthy non-pregnant women were enrolled. The whole blood were collected. The toxic element chromium (Cr), arsenic (As), cadmium (Cd), mercury (Hg), thallium (Tl), and lead (Pb) and essential elements magnesium (Mg), calcium (Ca), manganese (Mn), iron (Fe), copper (Cu), and zinc (Zn) were determined by using a inductively coupled plasma mass spectrometry (ICP-MS)–based method. All the metal(loid)s, except for Cd, Hg, and Tl, showed different levels in whole blood of the pregnant women compared with the non-pregnant women (p < 0.05), among which Mg, Fe, As, and Pb were lower while Ca, Cr, Mn, Cu, and Zn were higher. Moreover, whole blood levels of Mg, Mn, Fe, Cu, and Zn showed significant variations among different gestational ages, while As and Cd showed significant variations among different maternal ages. In addition, Fe-Mg, Fe-Zn, Cu-Ca, and Hg-As were found to be correlated positively in whole blood of the pregnant women, while Fe-Ca, Zn-Ca, and Fe-Cu were correlated negatively. The systematic information of toxic and essential elements in whole blood of pregnant women living in Wuhan of China can provide important guidance for the supplementation of essential elements during pregnancy and for biomonitoring of environmental overexposure.
Similar content being viewed by others
References
McKeating DR, Fisher JJ, Perkins AV (2019) Elemental metabolomics and pregnancy outcomes. Nutrients 11(1):73. https://doi.org/10.3390/nu11010073
Abu-Saad K, Fraser D (2010) Maternal nutrition and birth outcomes. Epidemiol Rev 32(1):5–25. https://doi.org/10.1093/epirev/mxq001
Blumfield ML, Hure AJ, Macdonald-Wicks L, Smith R, Collins CE (2013) Micronutrient intakes during pregnancy in developed countries: systematic review and meta-analysis. Nutr Rev 71(2):118–132. https://doi.org/10.1111/nure.12003
Mistry HD, Williams PJ (2011) The importance of antioxidant micronutrients in pregnancy. Oxidative Med Cell Longev 2011:841749–841712. https://doi.org/10.1155/2011/841749
Caserta D, Graziano A, Lo Monte G, Bordi G, Moscarini M (2013) Heavy metals and placental fetal-maternal barrier: a mini-review on the major concerns. Eur Rev Med Pharmacol Sci 17(16):2198–2206
Chen Z, Myers R, Wei T, Bind E, Kassim P, Wang G, Ji Y, Hong X, Caruso D, Bartell T, Gong Y, Strickland P, Navas-Acien A, Guallar E, Wang X (2014) Placental transfer and concentrations of cadmium, mercury, lead, and selenium in mothers, newborns, and young children. J Expo Sci Environ Epidemiol 24(5):537–544. https://doi.org/10.1038/jes.2014.26
Bocca B, Ruggieri F, Pino A, Rovira J, Calamandrei G, Martínez MÁ, Domingo JL, Alimonti A, Schuhmacher M (2019) Human biomonitoring to evaluate exposure to toxic and essential trace elements during pregnancy. Part A. concentrations in maternal blood, urine and cord blood. Environ Res 177:108599. https://doi.org/10.1016/j.envres.2019.108599
King JC (2000) Physiology of pregnancy and nutrient metabolism. Am J Clin Nutr 71(5 Suppl):1218S–1225S. https://doi.org/10.1093/ajcn/71.5.1218s
Zhang Z, Yuan E, Liu J, Lou X, Jia L, Li X, Zhang L (2013) Gestational age-specific reference intervals for blood copper, zinc, calcium, magnesium, iron, lead, and cadmium during normal pregnancy. Clin Biochem 46(9):777–780. https://doi.org/10.1016/j.clinbiochem.2013.03.004
Jain RB, Choi YS (2015) Normal reference ranges for and variability in the levels of blood manganese and selenium by gender, age, and race/ethnicity for general U.S. population. J Trace Elem Med Biol 30:142–152. https://doi.org/10.1016/j.jtemb.2014.12.004
Skalny AV, Tinkov AA, Voronina I, Terekhina O, Skalnaya MG, Bohan TG, Agarkova LA, Kovas Y (2018) The impact of lifestyle factors on age-related differences in hair trace element content in pregnant women in the third trimester [pdf]. Acta Sci Pol Technol Aliment 17(1):83–89. https://doi.org/10.17306/j.afs.2018.0539\
Zhang F, Wang ZW, Cheng HR, Lv XP, Gong W, Wang XM, Zhang G (2015) Seasonal variations and chemical characteristics of PM(2.5) in Wuhan, central China. Sci Total Environ 518-519:97–105. https://doi.org/10.1016/j.scitotenv.2015.02.054
Zeng HL, Li H, Lu J, Guan Q, Cheng L (2019) Assessment of 12 metals and metalloids in blood of general populations living in Wuhan of China by ICP-MS. Biol Trace Elem Res 189(2):344–353. https://doi.org/10.1007/s12011-018-1486-8
Reddy YS, Aparna Y, Ramalaksmi BA, Kumar BD (2014) Lead and trace element levels in placenta, maternal and cord blood: a cross-sectional pilot study. J Obstet Gynaecol Res 40(12):2184–2190. https://doi.org/10.1111/jog.12469
Jeong KS, Ha E, Shin JY, Park H, Hong YC, Ha M, Kim S, Lee SJ, Lee KY, Kim JH, Kim Y (2017) Blood heavy metal concentrations in pregnant Korean women and their children up to age 5 years: Mothers’ and Children’s Environmental Health (MOCEH) birth cohort study. Sci Total Environ 605-606:784–791. https://doi.org/10.1016/j.scitotenv.2017.06.007
Liu X, Zhang Y, Piao J, Mao D, Li Y, Li W, Yang L, Yang X (2017) Reference values of 14 serum trace elements for pregnant Chinese women: a cross-sectional study in the China Nutrition and Health Survey 2010-2012. Nutrients 9(3). https://doi.org/10.3390/nu9030309
Jiang Y, Wang H, Chen J, Zhang G, Chen L, Dai W, Zhou W, Yang H, Shi H (2011) Blood lead levels during different trimesters of pregnancy and the possible influencing factors in Chengdu, China. Biol Trace Elem Res 144(1-3):27–35. https://doi.org/10.1007/s12011-011-9020-2
Li A, Zhuang T, Shi J, Liang Y, Song M (2019) Heavy metals in maternal and cord blood in Beijing and their efficiency of placental transfer. J Environ Sci 80:99–106. https://doi.org/10.1016/j.jes.2018.11.004
Bocca B, Ruggieri F, Pino A, Rovira J, Calamandrei G, Martinez MA, Domingo JL, Alimonti A, Schuhmacher M (2019) Human biomonitoring to evaluate exposure to toxic and essential trace elements during pregnancy. Part A. concentrations in maternal blood, urine and cord blood. Environ Res 177:108599. https://doi.org/10.1016/j.envres.2019.108599
Rollin HB, Rudge CV, Thomassen Y, Mathee A, Odland JO (2009) Levels of toxic and essential metals in maternal and umbilical cord blood from selected areas of South Africa--results of a pilot study. J Environ Monit : JEM 11(3):618–627. https://doi.org/10.1039/b816236k
Kopp RS, Kumbartski M, Harth V, Bruning T, Kafferlein HU (2012) Partition of metals in the maternal/fetal unit and lead-associated decreases of fetal iron and manganese: an observational biomonitoring approach. Arch Toxicol 86(10):1571–1581. https://doi.org/10.1007/s00204-012-0869-4
Ashrap P, Watkins DJ, Mukherjee B, Boss J, Richards MJ, Rosario Z, Velez-Vega CM, Alshawabkeh A, Cordero JF, Meeker JD (2020) Predictors of urinary and blood Metal(loid) concentrations among pregnant women in Northern Puerto Rico. Environ Res 183:109178. https://doi.org/10.1016/j.envres.2020.109178
Motawei SM, Gouda HE (2016) Screening of blood levels of mercury, cadmium, and copper in pregnant women in Dakahlia, Egypt: new attention to an old problem. Biol Trace Elem Res 171(2):308–314. https://doi.org/10.1007/s12011-015-0525-y
Rudge CV, Calderon IM, Rudge MV, Volpato G, Silva JL, Duarte G, Neto CM, Sass N, Mattar R, Rollin HB, Thomassen Y, Odland JO (2011) Toxic and essential elements in blood from delivering women in selected areas of Sao Paulo State, Brazil. J Environ Monit : JEM 13(3):563–571. https://doi.org/10.1039/c0em00570c
Guy M, Accrombessi M, Fievet N, Yovo E, Massougbodji A, Le Bot B, Glorennec P, Bodeau-Livinec F, Briand V (2018) Toxics (Pb, Cd) and trace elements (Zn, Cu, Mn) in women during pregnancy and at delivery, South Benin, 2014-2015. Environ Res 167:198–206. https://doi.org/10.1016/j.envres.2018.06.054
Ladipo O (2000) Nutrition in pregnancy: mineral and vitamin supplements. Am J Clin Nutr 72:280S–290S. https://doi.org/10.1093/ajcn/72.1.280S
Anetor JI, Adelaja O, Adekunle AO (2003) Serum micronutrient levels, nucleic acid metabolism and antioxidant defences in pregnant Nigerians: implications for fetal and maternal health. Afr J Med Med Sci 32(3):257–262
Takser L, Lafond J, Bouchard M, St-Amour G, Mergler D (2004) Manganese levels during pregnancy and at birth: relation to environmental factors and smoking in a Southwest Quebec population. Environ Res 95(2):119–125. https://doi.org/10.1016/j.envres.2003.11.002
Anetor JI, Ajose OA, Adeleke FN, Olaniyan-Taylor GO, Fasola FA (2010) Depressed antioxidant status in pregnant women on iron supplements: pathologic and clinical correlates. Biol Trace Elem Res 136(2):157–170. https://doi.org/10.1007/s12011-009-8534-3
O’Brien KO, Zavaleta N, Caulfield LE, Wen J, Abrams SA (2000) Prenatal iron supplements impair zinc absorption in pregnant Peruvian women. J Nutr 130(9):2251–2255. https://doi.org/10.1093/jn/130.9.2251
Riedt CS, Buckley BT, Brolin RE, Ambia-Sobhan H, Rhoads GG, Shapses SA (2009) Blood lead levels and bone turnover with weight reduction in women. J Expo Sci Environ Epidemiol 19(1):90–96. https://doi.org/10.1038/jes.2008.5
Hertz-Picciotto I, Schramm M, Watt-Morse M, Chantala K, Anderson J, Osterloh J (2000) Patterns and determinants of blood lead during pregnancy. Am J Epidemiol 152(9):829–837. https://doi.org/10.1093/aje/152.9.829
Schwalfenberg GK, Genuis SJ (2015) Vitamin D, essential minerals, and toxic elements: exploring interactions between nutrients and toxicants in clinical medicine. Sci World J 2015:318595–318598. https://doi.org/10.1155/2015/318595
Zeng HL, Liu CW, Lu J, Wang X, Cheng L (2019) Analysis of urinary trace element levels in general population of Wuhan in central China. Environ Sci Pollut Res Int 26:27823–27831. https://doi.org/10.1007/s11356-019-05973-7
Maia AR, Soler-Rodriguez F, Perez-Lopez M (2017) Concentration of 12 metals and metalloids in the blood of White Stork (Ciconia ciconia): basal values and influence of age and gender. Arch Environ Contam Toxicol 73(4):522–532. https://doi.org/10.1007/s00244-017-0431-8
Kim HJ, Lim HS, Lee KR, Choi MH, Kang NM, Lee CH, Oh EJ, Park HK (2017) Determination of trace metal levels in the general population of Korea. Int J Environ Res Public Health 14(7). https://doi.org/10.3390/ijerph14070702
Funding
This work was supported by National Natural Science Foundation of China (31600666).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Ethical Approval
Ethical approval was obtained from the Ethics Committee of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology in Wuhan, China. All the procedures involving human samples conformed to the principles outlined in the Declaration of Helsinki.
Informed Consent
Participation was voluntary and written informed consent obtained in all cases.
Competing Interests
The authors declare that they have no conflict of interest.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Gong, L., Yang, Q., Liu, CWB. et al. Assessment of 12 Essential and Toxic Elements in Whole Blood of Pregnant and Non-pregnant Women Living in Wuhan of China. Biol Trace Elem Res 199, 2121–2130 (2021). https://doi.org/10.1007/s12011-020-02337-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12011-020-02337-y