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Association of Circulating and Aortic Zinc and Copper Levels with Clinical Abdominal Aortic Aneurysm: a Meta-analysis

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Abstract

It remains obscure whether circulating aortic zinc (Zn) and copper (Cu) levels are associated with the progress of human abdominal aortic aneurysms (AAA). Therefore, we conducted a meta-analysis to explore this relationship. A literature search on circulating and aortic zinc and copper levels and AAA patients was conducted using online databases including PubMed, Embase, and Cochrane up to March 20, 2019. To compare Zn and Cu concentrations in AAA patients with those in aortic occlusive disease (AOD) patients or healthy aorta donors or healthy blood donors, pooled weighted mean difference (WMD) and its 95% confidence interval (CI) were calculated. Subgroup analysis, sensitivity analysis, and meta-regression analysis were applied to explain the heterogeneity and evaluate the robustness of combined results. A total of 10 cross-sectional studies, including 252 cases and 304 controls, were used for meta-analysis. We found that circulating zinc and Zn/Cu ratio in AAA patients were significantly lower [WMD (95%CI): − 2.23 (− 4.10, − 0.36); − 0.18 (− 0.31, − 0.05), respectively] than those in non-AAA patients. Similarly, aneurysmal aorta had significantly lower zinc levels and Zn/Cu ratio [WMD (95%CI): − 9.22 (− 15.37, − 3.07); − 6.46 (− 10.14, − 2.77), respectively] than those in control group. No difference in circulating or aortic copper levels was noted between AAA patients and control group [WMD (95%CI): - 0.24 (- 2.09, 1.61); 0.30 (- 0.01, 0.61) , respectively]. Our meta-analysis suggests that zinc levels and Zn-Cu ratio, but not copper levels, may influence aneurysmal progress of AAA.

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Acknowledgments

This study was supported by the grant from National Natural Science Foundation, China (Grant No. 81770475), and the Major Research and Development Projects for the Zhejiang Science and Technology Agency, China (Grant No. 2017C03034).

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    1. Department of Cardiology, Taizhou Hospital Affiliated to Wenzhou Medical University, Linhai, 317000, Zhejiang Province, China

      Tingting Chen, Hongliang Zhang, Yang Zhang, Mengqi Yang, Juntao Wu, Minjun Yang, Jiangbo Lin, Jianjun Jiang & Xiaofeng Chen

    2. Laboratory of Cardiovascular Disease, Taizhou Hospital Affiliated to Wenzhou Medical University, Linhai, 317000, Zhejiang Province, China

      Tingting Chen, Hongliang Zhang, Yang Zhang, Mengqi Yang, Juntao Wu, Minjun Yang, Jiangbo Lin, Jianjun Jiang & Xiaofeng Chen

    3. Department of Endocrinology, Taizhou Hospital Affiliated to Wenzhou Medical University, Linhai, 317000, Zhejiang Province, China

      Weixu Gao

    4. Department of Cardiology, Zhejiang Hospital, Hangzhou, 310013, Zhejiang Province, China

      Lijiang Tang

    5. Department of Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA

      Baohui Xu

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    Chen, T., Zhang, H., Zhang, Y. et al. Association of Circulating and Aortic Zinc and Copper Levels with Clinical Abdominal Aortic Aneurysm: a Meta-analysis. Biol Trace Elem Res 199, 513–526 (2021). https://doi.org/10.1007/s12011-020-02187-8

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