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Insights into the Role of Magnesium Ions in Affecting Osteogenic Differentiation of Mesenchymal Stem Cells

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Abstract

Bone marrow mesenchymal stem cells (MSCs) are multipotent stem cells with the ability to differentiate into bone-producing cells, which is essential for bone formation. Magnesium biomedical materials, such as biodegradable matters with osteoinductive properties, play a vital role in the osteogenic differentiation of MSCs. International and Chinese studies have shown that magnesium ions, which are produced by biodegradation, mainly achieve this effect by regulating the expression of genes and proteins associated with osteogenesis, activating multiple signal pathways, elevating autophagic activities, and adjusting the pH in the microenvironment. It is of great significance to study the regulatory mechanisms and identify the optimal conditions that how magnesium ions promote osteogenic differentiation of MSCs. In this study, we summarized the regulatory mechanisms noted above.

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Funding

This study was supported by the funding of ‘San-ming’ Project of Medicine in Shenzhen (No. SZSM201612092) and the Research and Development Projects of Shenzhen (No. JCYJ20170307111755218), and the basic research project of Peking University Shenzhen hospital (NO.JCYJ2018004), Natural Science Foundation of Guangdong Province, China (2019A1515011290)

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Authors and Affiliations

  1. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, 518036, People’s Republic of China

    Tiantian Qi, Jian Weng, Fei Yu, Weifei Zhang, Guoqing Li, Haotian Qin, Zhen Tan & Hui Zeng

  2. Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, 518036, People’s Republic of China

    Tiantian Qi, Jian Weng, Fei Yu, Weifei Zhang, Guoqing Li, Haotian Qin, Zhen Tan & Hui Zeng

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  1. Tiantian Qi
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  2. Jian Weng
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  3. Fei Yu
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  4. Weifei Zhang
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  5. Guoqing Li
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  6. Haotian Qin
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  7. Zhen Tan
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  8. Hui Zeng
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Correspondence to Hui Zeng.

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Qi, T., Weng, J., Yu, F. et al. Insights into the Role of Magnesium Ions in Affecting Osteogenic Differentiation of Mesenchymal Stem Cells. Biol Trace Elem Res 199, 559–567 (2021). https://doi.org/10.1007/s12011-020-02183-y

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