Skip to main content
Log in

The Relationship Between Metabolic Syndrome Development and Tissue Trace Elements Status and Inflammatory Markers

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

Insulin resistance, impaired glucose regulation, dyslipidemia, low-grade inflammation, and elevated blood pressure are main components of the metabolic syndrome (MetS). Trace elements, especially zinc (Zn) and copper (Cu) and cytokines, have physiological importance due to their presence in inflammatory processes and glucose metabolism. Therefore, this study aimed to investigate the potential relationship between cytokine responses and trace elements in different tissues of sucrose-induced MetS rats compared with healthy controls (n:7/groups). Tissue Zn concentrations are found to be decreased in the liver (p = 0.00) and pancreas (p < 0.01) and increased in the kidney (p = 0.00) and heart tissues (p < 0.001) of MetS group. Serum Zn levels were also found to be decreased in MetS compared with control group (p < 0.01), while there was any significant difference in serum Cu concentrations between groups. The Cu concentration (p < 0.01) was found decreased, and Zn/Cu ratio (p < 0.01) was found increased in kidney tissues. TNF-α, IL-6 levels were found increased in MetS tissues. With this study, the Zn and Cu concentrations and their relationships with inflammatory response in different tissues in MetS are reported for the first time in the literature. Serum and tissue Zn levels with diversities in distribution were found to have a higher impact on MetS pathogenesis than Cu levels. It has been concluded that there is a relationship between Zn and Cu concentrations and inflammatory marker levels in MetS pathophysiological mechanisms.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. NIH and NHBL ATP III guidelines (2001). https://www.nhlbi.nih.gov/files/docs/guidelines/atglance.pdf. Accessed 14 Dec 2019

  2. Srikanthan K, Feyh A, Visweshwar H, Shapiro JI, Sodhi K (2016) Systematic review of metabolic syndrome biomarkers: a panel for early detection, management, and risk stratification in the West Virginian population. Int J Med Sci 13:25–38. https://doi.org/10.7150/ijms.13800

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Milanino R, Cassini A, Conforti A, Franco L, Marrella M, Moretti U, Velo GJA (1986) Copper and zinc status during acute inflammation: studies on blood, liver and kidneys metal levels in normal and inflamed rats. Agents Actions 19:215–223

    Article  CAS  Google Scholar 

  4. Yalcın S, Kayaalti Z, Söylemezoglu T (2011) Role of interleukin-6 −174 G/C promoter polymorphism in trace metal levels of autopsy kidney and liver tissues. Int J Hyg Environ Health 214:219–224. https://doi.org/10.1016/j.ijheh.2011.01.005

    Article  CAS  PubMed  Google Scholar 

  5. Hojyo S, Fukada T (2016) Roles of zinc signaling in the immune system. J Immunol Res 2016

  6. Kardos J, Héja L, Simon Á, Jablonkai I, Kovács R, Jemnitz K (2018) Copper signalling: causes and consequences. Cell Commun Signal 16:1–22

    Article  Google Scholar 

  7. Figlewicz DP, Forhan SE, Hodgson AT, Grodsky GM (1984) 65Zinc and endogenous zinc content and distribution in islets in relationship to insulin content. Endocrinology 115:877–881

    Article  CAS  Google Scholar 

  8. Foster M, Samman S (2012) Zinc and regulation of inflammatory cytokines: implications for cardiometabolic disease. Nutrients 4:676–694

    Article  CAS  Google Scholar 

  9. Gammoh N, Rink L (2017) Zinc in infection and inflammation. Nutrients 9:624

    Article  Google Scholar 

  10. Taneja SK, Mandal R, Girhotra S (2006) Long term excessive Zn-supplemention promotes metabolic syndrome-X in Wistar rats fed sucrose and fat rich semisynthetic diet. Indian J Exp Biol 44:705–718

    CAS  PubMed  Google Scholar 

  11. Kassem AA, Salah HE (2016) Plasma levels of Inflmamatory cytokines in Egyptian adults with metabolic syndrome. Eur J Pharm Med Res 12:668–675

    Google Scholar 

  12. Okatan EN, Durak AT, Turan B (2016) Electrophysiological basis of metabolic-syndrome-induced cardiac dysfunction. Can J Physiol Pharmacol 94:1064–1073

    Article  CAS  Google Scholar 

  13. Vayenas D, Repanti M, Vassilopoulos A, Papanastasiou D (1998) Influence of iron overload on manganese, zinc, and copper concentration in rat tissues in vivo: study of liver, spleen, and brain. Int J Clin Lab Res 28:183–186

    Article  CAS  Google Scholar 

  14. ThePerkin-ElmerCorporation (1996) Analytical methods for atomic absorption spectroscopy. USA

  15. Freitas EP, Cunha AT, Aquino SL, Pedrosa LF, Lima SC, Lima JG, Almeida MG, Sena-Evangelista KC (2017) Zinc status biomarkers and cardiometabolic risk factors in metabolic syndrome: a case control study. Nutrients 9. https://doi.org/10.3390/nu9020175

  16. Gao H, Dai W, Zhao L, Min J, Wang F (2018) The role of zinc and zinc homeostasis in macrophage function. J Immunol Res 2018

  17. Zhang C, Lu X, Tan Y, Li B, Miao X, Jin L, Shi X, Zhang X, Miao L, Li X, Cai L (2012) Diabetes-induced hepatic pathogenic damage, inflammation, oxidative stress, and insulin resistance was exacerbated in zinc deficient mouse model. PLoS One 7:e49257. https://doi.org/10.1371/journal.pone.0049257

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Kennedy ML, Failla ML, Smith JC Jr (1986) Influence of genetic obesity on tissue concentrations of zinc, copper, manganese and iron in mice. J Nutr 116:1432–1441. https://doi.org/10.1093/jn/116.8.1432

    Article  CAS  PubMed  Google Scholar 

  19. Church SJ, Begley P, Kureishy N, McHarg S, Bishop PN, Bechtold DA, Unwin RD, Cooper GJ (2015) Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: a potential model for study of defective copper regulation in metabolic liver disease. Biochem Biophys Res Commun 460:549–554. https://doi.org/10.1016/j.bbrc.2015.03.067

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Gatiatulina ER, Popova EV, Polyakova VS, Skalnaya AA, Agletdinov EF, Nikonorov AA, Skalny AV, Tinkov AA (2017) Evaluation of tissue metal and trace element content in a rat model of non-alcoholic fatty liver disease using ICP-DRC-MS. J Trace Elem Med Biol 39:91–99. https://doi.org/10.1016/j.jtemb.2016.08.007

    Article  CAS  PubMed  Google Scholar 

  21. Turan B (2019) A brief overview from the physiological and detrimental roles of zinc homeostasis via zinc transporters in the heart. Biol Trace Elem Res 188:160–176

    Article  CAS  Google Scholar 

  22. Yu X, Huang L, Zhao J, Wang Z, Yao W, Wu X, Huang J, Bian B (2018) The relationship between serum zinc level and heart failure: a meta-analysis. Biomed Res Int 2018:1–9

    Google Scholar 

  23. Henrotte JG, Santarromana M, Franck G, Guicheney P, Boulu R, Bourdon R (1992) High cardiac zinc levels in spontaneously hypertensive rats. J Hypertens 10:553–559

    Article  CAS  Google Scholar 

  24. Stadler N, Heeneman S, Vöö S, Stanley N, Giles GI, Gang BP, Croft KD, Mori TA, Vacata V, Daemen MJ (2012) Reduced metal ion concentrations in atherosclerotic plaques from subjects with type 2 diabetes mellitus. Atherosclerosis 222:512–518

    Article  CAS  Google Scholar 

  25. Ranasinghe P, Mathangasinghe Y, Jayawardena R, Hills AP, Misra A (2017) Prevalence and trends of metabolic syndrome among adults in the asia pacific region, a systematic review. BMC Public Health 17:1–9. https://doi.org/10.1186/s12889-017-4041-1

    Article  Google Scholar 

  26. Søndergaard LG, Stoltenberg M, Doering P, Flyvbjerg A, Rungby J (2006) Zinc ions in the endocrine andexocrine pancreas of zinc deficient rats. Histol Histopathol 21:619–625

    PubMed  Google Scholar 

  27. Somboonwong J, Traisaeng S, Saguanrungsirikul S (2015) Moderate-intensity exercise training elevates serum and pancreatic zinc levels and pancreatic ZnT8 expression in streptozotocin-induced diabetic rats. Life Sci 139:46–51

    Article  CAS  Google Scholar 

  28. Zou Q, Gang K, Yang Q, Liu X, Tang X, Lu H, He J, Luo L (2018) The CCCH-type zinc finger transcription factor Zc3h8 represses NF-κB–mediated inflammation in digestive organs in zebrafish. J Biol Chem 293:11971–11983

    Article  CAS  Google Scholar 

  29. Vujasinovic M, Hedström A, Maisonneuve P, Valente R, von Horn H, Löhr J-M, Haas SL (2019) Zinc deficiency in patients with chronic pancreatitis. World J Gastroenterol 25:600

    Article  CAS  Google Scholar 

Download references

Funding

This study was supported by Ankara University Scientific Research Projects Directorate with the project number 19L0230005.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Nuray Yazihan.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

This study has been approved by the Ethics Committee of the Ankara University Local Ethics Committee for Experimental Animals (2019-5-50).

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Akdas, S., Turan, B., Durak, A. et al. The Relationship Between Metabolic Syndrome Development and Tissue Trace Elements Status and Inflammatory Markers. Biol Trace Elem Res 198, 16–24 (2020). https://doi.org/10.1007/s12011-020-02046-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12011-020-02046-6

Keywords

Navigation