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Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial

Biological Trace Element Research volume 191, pages 331–337 (2019)Cite this article

Abstract

This study was carried out to evaluate the effects of selenium supplementation on glycemic control, lipid profiles, and biomarkers of inflammation and oxidative stress in patients undergoing for coronary artery bypass grafting (CABG) surgery. This randomized, double-blind, placebo-controlled trial was performed among 33 patients undergoing for CABG surgery, aged 40–85 years old. Subjects were randomly allocated into two groups to intake either 200 μg/day selenium supplements as selenium yeast (n = 17) or placebo (n = 16) for 4 weeks. Glycemic control, lipid profiles, and biomarkers of inflammation and oxidative stress were assessed at baseline and at the end of trial. After the 4-week intervention, selenium supplementation significantly decreased fasting plasma glucose (FPG) (β, 6.76 mg/dL; 95% CI, − 13.13, − 0.40; P = 0.03), insulin (β, − 1.14 μIU/mL; 95% CI, − 2.01, − 0.28; P = 0.01); homeostasis model of assessment-estimated insulin resistance (HOMA-IR) (β − 0.35; 95% CI, − 0.62, − 0.08; P = 0.01); and total-/HDL-cholesterol ratio (β − 0.31; 95% CI, − 0.51, − 0.09; P = 0.008); and significantly increased HDL-cholesterol levels (β, 2.72 mg/dL; 95% CI, 0.89, 4.55; P = 0.005) compared with the placebo. Moreover, selenium supplementation led to a significant reduction in high-sensitivity C-reactive protein (hs-CRP) (β, − 0.68 mg/L; 95% CI, − 1.18, − 0.17; P = 0.01) and malondialdehyde (MDA) (β, − 0.27 μmol/L; 95% CI, − 0.47, − 0.07; P = 0.009), and a significant elevation in total glutathione (GSH) levels (β, 77.33 μmol/L; 95% CI, 56.11, 98.55; P < 0.001) compared with the placebo. Selenium supplementation did not affect other metabolic profiles. Overall, our study demonstrated that selenium supplementation for 4 weeks to patients undergoing for CABG surgery had beneficial effects on FPG, insulin, HOMA-IR, total-/HDL-cholesterol ratio, HDL-cholesterol, hs-CRP, GSH, and MDA levels, but did not affect other metabolic profiles. Clinical trial registration number: http://www.irct.ir: IRCT2017090533941N22.

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Funding

The current study was founded by a grant from the Vice-chancellor for Research, AUMS, and Iran.

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Affiliations

  1. Department of Anesthesiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran

    Alireza Kamali

  2. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran

    Elaheh Amirani & Zatollah Asemi

Authors
  1. Alireza Kamali
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  2. Elaheh Amirani
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  3. Zatollah Asemi
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Contributions

ZA contributed in conception, design, statistical analysis and drafting of the manuscript. AK and EA contributed in data collection and manuscript drafting. Z.A. supervised the study.

Corresponding author

Correspondence to Zatollah Asemi.

Ethics declarations

This investigation was done according to the principals of the Declaration of Helsinki and the study protocol was approved by the ethics committee of AUMS. All patients were informed about the aims and protocol of the study. Written informed consent was obtained from all subjects prior to the intervention.

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The authors declare that they have no conflict of interest.

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Kamali, A., Amirani, E. & Asemi, Z. Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial. Biol Trace Elem Res 191, 331–337 (2019). https://doi.org/10.1007/s12011-019-1636-7

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  • DOI: https://doi.org/10.1007/s12011-019-1636-7

Keywords

  • Selenium
  • Supplementation
  • Metabolic status
  • Coronary artery bypass grafting