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Vanadium Compounds as Biocatalyst Models

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Abstract

Peroxidovanadium(V) and oxidovanadium(IV) compounds have been tested as peroxidase-similar compounds. Their catalytic performance was tested on phenol red and pyrogallol substrates. Bromination kinetic studies revealed Michaelis-Menten behavior with respect to phenol red for both complexes. Catalytic efficiency is ~ 104 M−1 min−1. Both vanadium complexes showed the capacity to oxidize pyrogallol, but only the oxidovanadium (IV) complex follows Michaelis-Menten kinetics with respect to this substrate (Km = 1.05 × 10-3 M). Peroxidovanadium(V) complex displayed a more complex mechanism, and further studies became necessary to elucidate it. The structure-activity relationship was also assessed.

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Scheme 1
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Scheme 2
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Funding

This work was supported by the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET, PIP 0611), Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT, PICT16-1814), and Universidad Nacional de La Plata (UNLP, X777) of Argentina. EGF is a Research Fellow of CONICET. JEP and PAMW are Research Fellows of Comisión de Investigaciones Científicas de la Provincia de Buenos Aires (CICPBA) Argentina.

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  1. Center of Inorganic Chemistry (CEQUINOR, CONICET-CICPBA-UNLP)-Department of Chemistry-Faculty of Exact Sciences, National University of La Plata, Boulevard 120 e/60 y 64, 1900, B1900AVV, La Plata, Argentina

    Juliana E. Parente, Patricia A. M. Williams & Evelina G. Ferrer

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  1. Juliana E. Parente
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  2. Patricia A. M. Williams
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  3. Evelina G. Ferrer
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Correspondence to Evelina G. Ferrer.

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Parente, J.E., Williams, P.A.M. & Ferrer, E.G. Vanadium Compounds as Biocatalyst Models. Biol Trace Elem Res 195, 725–731 (2020). https://doi.org/10.1007/s12011-019-01874-5

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