Vanadium Compounds as Biocatalyst Models
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Peroxidovanadium(V) and oxidovanadium(IV) compounds have been tested as peroxidase-similar compounds. Their catalytic performance was tested on phenol red and pyrogallol substrates. Bromination kinetic studies revealed Michaelis-Menten behavior with respect to phenol red for both complexes. Catalytic efficiency is ~ 104 M−1 min−1. Both vanadium complexes showed the capacity to oxidize pyrogallol, but only the oxidovanadium (IV) complex follows Michaelis-Menten kinetics with respect to this substrate (Km = 1.05 × 10-3 M). Peroxidovanadium(V) complex displayed a more complex mechanism, and further studies became necessary to elucidate it. The structure-activity relationship was also assessed.
KeywordsVanadium complexes Biocatalyst models Peroxidase-similar activity Phenol red Pyrogallol
This work was supported by the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET, PIP 0611), Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT, PICT16-1814), and Universidad Nacional de La Plata (UNLP, X777) of Argentina. EGF is a Research Fellow of CONICET. JEP and PAMW are Research Fellows of Comisión de Investigaciones Científicas de la Provincia de Buenos Aires (CICPBA) Argentina.
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Conflict of Interest
The authors declare that they have no conflict of interest.
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