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The Effects of 50 nm Unmodified Nano-ZnO on Lipid Metabolism and Semen Quality in Male Mice

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A Correction to this article was published on 24 July 2019

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Abstract

Fifty male mice were exposed to 50 nm unmodified nano-ZnO through intragastric administration for 90 days to detect the long-term effects of unmodified nano-ZnO in mice. Results showed that the blood glucose, serum follicle stimulating hormone, luteinizing hormone, testosterone, and estradiol were significantly decreased (p < 0.05). The serum triglyceride, total cholesterol, and low-density lipoprotein were significantly increased (p < 0.05). The semen quality of the 160 mg/kg·bw group were significantly lowered (p < 0.05). The liver and testis catalase and CuZn-SOD activities were significantly elevated (p < 0.05). The abilities of •OH inhibition in the livers and testes of the 160 mg/kg·bw group were significantly lowered (p < 0.05). The liver and testis MDA levels of the 160 mg/kg·bw group were significantly elevated (p < 0.05). Results indicate that exposure of nano-ZnO could induce lipid metabolism disorder, hyperlipidemia, and reproductive toxicity to male mice through oxidative injury.

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  • 24 July 2019

    The original version of this article unfortunately contained a mistake. The correct title should be “The Effects of 50 nm Unmodified Nano-ZnO on Lipid Metabolism and Semen Quality in Male Mice”. The original article has been corrected.

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Funding

This work was supported by the National Natural Science Foundation of China (Nos. 31402263, 31872537, 41301562), the National Natural Science Foundation of Henan province (No. 182300410087), and the Key Scientific and Technological Project of Henan province (No. 182102110257).

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Authors and Affiliations

  1. College of Animal Science and Veterinary Medicine, Henan University of Science and Technology, No. 263 Kaiyuan Road, Luoyang, 471023, Henan, People’s Republic of China

    Tao Kong, Cai Zhang, Ji-Liang Zhang, Fan Yang, Guo-Yong Wang, Zi-Jun Yang, Dong-Ying Bai, Yun-Yun Shi, Tian-Qi Liu & Hai-Long Li

  2. Environmental and Animal Products Safety Laboratory of Key Discipline in University of Henan Province, No. 263 Kaiyuan Road, Luoyang, 471023, Henan, People’s Republic of China

    Tao Kong, Cai Zhang, Ji-Liang Zhang, Fan Yang & Zi-Jun Yang

  3. Library of Henan University of Science and Technology, No. 263 Kaiyuan Road, Luoyang, 471023, Henan, People’s Republic of China

    Shu-Hui Zhang

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  1. Tao Kong
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Correspondence to Tao Kong.

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The original version of this article was revised: The correct title should be “The Effects of 50 nm Unmodified Nano-ZnO on Lipid Metabolism and Semen Quality in Male Mice”.

Highlights

• Nano-ZnO could induce lipid metabolism disorder and reproductive toxicity.

• Nano-ZnO showed adverse effects on semen quality and spermatogenesis.

• The lipid metabolism disorder and reproductive toxicity induced by nano-ZnO might be through oxidative stress.

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Kong, T., Zhang, SH., Zhang, C. et al. The Effects of 50 nm Unmodified Nano-ZnO on Lipid Metabolism and Semen Quality in Male Mice. Biol Trace Elem Res 194, 432–442 (2020). https://doi.org/10.1007/s12011-019-01792-6

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  • DOI: https://doi.org/10.1007/s12011-019-01792-6

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