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Association Between Trace Element Status and Depression in HTLV-1-Infected Patients: a Retrospective Cohort Study

Biological Trace Element Research volume 191, pages 75–80 (2019)Cite this article

Abstract

Depression and Anxiety are two important public health problems that are known to be associated with viral infections. The association between the intake of nutrients such as zinc and copper with symptoms of depression has been studied previously. The aim of the current study was to investigate the association between depression with human T cell lymphotropic virus type 1 (HTLV-1) infection and serum content of zinc and copper in a large Iranian population cohort. The study population consisted of 279 HTLV-1-positive patients who were identified after recruitment as part of a large cohort study: the Mashhad Stroke and Heart Association Disorder (MASHAD) study. They were divided into two groups of diagnosed with or without depression based on their symptoms. Serum zinc and copper levels of all subjects were measured using the flame atomic absorption spectrometry. The population sample comprised of 279 individuals infected with HTLV-1 of whom 192 (68.8%) were women. The mean serum zinc in the group with and without depression was 78.69 ± 13.79 μg/dl and 86.87 ± 19.44 μg/dl, respectively (p < 0.001). Also, the serum copper level was higher in the depressive group (116.75 ± 39.56) than in the non-depressive group (104.76 ± 30.77) (p 0.004). The association between serum zinc and copper with depression in HTLV-1-infected patients which was shown in this study could be considered in the treatment strategies in these patients.

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References

  1. Galvão-Castro B, Loures L, Rodriques L, Sereno A, Ferreira O Jr, Franco L et al (1997) Distribution of human T-lymphotropic virus type I among blood donors: a nationwide Brazilian study. Transfusion 37(2):242–243

    PubMed  Article  Google Scholar 

  2. Carneiro-Proietti ABF, Catalan-Soares B, Proietti FA (2002) Human T cell lymphotropic viruses (HTLV-I/II) in South America: should it be a public health concern? J Biomed Sci 9(6):587–595

    PubMed  Article  Google Scholar 

  3. Hlela C, Shepperd S, Khumalo NP, Taylor GP (2009) The prevalence of human T-cell lymphotropic virus type 1 in the general population is unknown. AIDS Rev 11(4):205–214

    PubMed  Google Scholar 

  4. Bhigjee A, Harvey M, Windsor I, Bill P (1989) Blood transfusion and HTLV-I-associated myelopathy. South African medical journal= Suid-Afrikaanse tydskrif vir geneeskunde 76(12):700

    CAS  PubMed  Google Scholar 

  5. Gessain A, Vernant J, Maurs L, Barin F, Gout O, Calender A (1985) Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 326(8452):407–410

    Article  Google Scholar 

  6. Carvalho AGJ, Galvão-Phileto AV, Lima NS, RSd J, Galvão-Castro B, Lima MG (2009) Frequency of mental disturbances in HTLV-1 patients in the state of Bahia, Brazil. Braz J Infect Dis 13(1):5–8

    PubMed  Article  Google Scholar 

  7. Kessler RC, Barber C, Birnbaum HG, Frank RG, Greenberg PE, Rose RM, Simon GE, Wang P (1999) Depression in the workplace: effects on short-term disability. Health Aff 18(5):163–171

    CAS  Article  Google Scholar 

  8. Murray CJ, Lopez AD, Organization WH. The global burden of disease: a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020: summary. 1996

    Google Scholar 

  9. Harden CL (2002) The co-morbidity of depression and epilepsy epidemiology, etiology, and treatment. Neurology 59(6 suppl 4):S48–S55

    CAS  PubMed  Article  Google Scholar 

  10. Kamerow DB (1988) Anxiety and depression in the medical setting: an overview. Med Clin North Am 72(4):745–751

    CAS  PubMed  Article  Google Scholar 

  11. Druss BG, Schlesinger M, Allen HM Jr (2001) Depressive symptoms, satisfaction with health care, and 2-year work outcomes in an employed population. Am J Psychiatr 158(5):731–734

    CAS  PubMed  Article  Google Scholar 

  12. Pohjasvaara T, Vataja R, Leppävuori A, Kaste M, Erkinjuntti T (2001) Depression is an independent predictor of poor long-term functional outcome post-stroke. Eur J Neurol 8(4):315–319

    CAS  PubMed  Article  Google Scholar 

  13. Dwight MM, Kowdley KV, Russo JE, Ciechanowski PS, Larson AM, Katon WJ (2000) Depression, fatigue, and functional disability in patients with chronic hepatitis C. J Psychosom Res 49(5):311–317

    CAS  PubMed  Article  Google Scholar 

  14. Ickovics JR, Hamburger ME, Vlahov D, Schoenbaum EE, Schuman P, Boland RJ, Moore J, HIV Epidemiology Research Study Group (2001) Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women: longitudinal analysis from the HIV Epidemiology Research Study. JAMA 285(11):1466–1474

    CAS  PubMed  Article  Google Scholar 

  15. McDaniel JS, Fowlie E, Summerville MB, Farber EW, Cohen-Cole SA (1995) An assessment of rates of psychiatric morbidity and functioning in HIV disease. Gen Hosp Psychiatry 17(5):346–352

    CAS  PubMed  Article  Google Scholar 

  16. Gascón MRP, Capitão CG, Casseb J, Nogueira-Martins MCF, Smid J, Oliveira ACP (2011) Prevalence of anxiety, depression and quality of life in HTLV-1 infected patients. Braz J Infect Dis 15(6):578–582

    PubMed  Article  Google Scholar 

  17. Russo A (2011) Analysis of plasma zinc and copper concentration, and perceived symptoms, in individuals with depression, post zinc and anti-oxidant therapy. Nutr Metab Insights 4:NMI. S6760

    Article  CAS  Google Scholar 

  18. Maret W (2013) Zinc biochemistry: from a single zinc enzyme to a key element of life. Adv Nutr 4(1):82–91

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  19. Ghasemi A, Zahediasl S, Hosseini-Esfahani F, Azizi F (2012) Reference values for serum zinc concentration and prevalence of zinc deficiency in adult Iranian subjects. Biol Trace Elem Res 149(3):307–314

    CAS  PubMed  Article  Google Scholar 

  20. Skalnaya MG, Skalny AV (2018) Essential trace elements in human health: a physician’s view

    Google Scholar 

  21. Otten JJ, Hellwig JP, Meyers LD (2006) Dietary reference intakes: the essential guide to nutrient requirements. National Academies Press

  22. Ghayour-Mobarhan M, Moohebati M, Esmaily H, Ebrahimi M, Parizadeh SMR, Heidari-Bakavoli AR, Safarian M, Mokhber N, Nematy M, Saber H, Mohammadi M, Andalibi MSS, Ferns GA, Azarpazhooh MR (2015) Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study: design, baseline characteristics and 10-year cardiovascular risk estimation. Int J Public Health 60(5):561–572

    PubMed  Article  Google Scholar 

  23. Hamedi A, Akhlaghi F, Meshkat Z, Sezavar M, Nomani H, Meshkat M (2012) The prevalence of human T-cell lymphotropic virus type 1 in pregnant women and their newborns. ISRN Obstet Gynecol 2012:1–5

    Article  Google Scholar 

  24. Dozois DJ, Dobson KS, Ahnberg JL (1998) A psychometric evaluation of the Beck Depression Inventory–II. Psychol Assess 10(2):83–89

    Article  Google Scholar 

  25. Scogin F, Beutler L, Corbishley A, Hamblin D (1988) Reliability and validity of the short form Beck Depression Inventory with older adults. J Clin Psychol 44(6):853–857

    CAS  PubMed  Article  Google Scholar 

  26. Ghayour-Mobarhan M, Shapouri-Moghaddam A, Azimi-Nezhad M, Esmaeili H, Parizadeh S, Safarian M et al (2009) The relationship between established coronary risk factors and serum copper and zinc concentrations in a large Persian cohort. J Trace Elem Med Biol 23(3):167–175

    CAS  PubMed  Article  Google Scholar 

  27. Taylor A (1996) Detection and monitoring of disorders of essential trace elements. Ann Clin Biochem 33(6):486–510

    CAS  PubMed  Article  Google Scholar 

  28. Galvão-Castro AV, Boa-Sorte N, Kruschewsky RA, Grassi MFR, Galvão-Castro B (2012) Impact of depression on quality of life in people living with human T cell lymphotropic virus type 1 (HTLV-1) in Salvador, Brazil. Qual Life Res 21(9):1545–1550

    PubMed  Article  Google Scholar 

  29. Stumpf BP, Carneiro-Proietti AB, Proietti FA, Rocha FL, GROUP IHR (2008) Higher rate of major depression among blood donor candidates infected with human t-cell lymphotropic virus type 1. Int J Psychiatry Med 38(3):345–355

    PubMed  Article  Google Scholar 

  30. Silva MT, Galvao TF, Martins SS, Pereira MG (2014) Prevalence of depression morbidity among Brazilian adults: a systematic review and meta-analysis. Rev Bras Psiquiatr 36(3):262–270

    PubMed  Article  Google Scholar 

  31. Tayefi M, Shafiee M, Kazemi-Bajestani SMR, Esmaeili H, Darroudi S, Khakpouri S, Mohammadi M, Ghaneifar Z, Azarpajouh MR, Moohebati M, Heidari-Bakavoli A, Parizadeh MR, Nematy M, Safarian M, Ebrahimi M, Ferns GA, Mokhber N, Ghayour-Mobarhan M (2017) Depression and anxiety both associate with serum level of hs-CRP: a gender-stratified analysis in a population-based study. Psychoneuroendocrinology 81:63–69

    CAS  PubMed  Article  Google Scholar 

  32. Singh N, Gayowski T, Wagener MM, Marino IR (1997) Vulnerability to psychologic distress and depression in patients with end-stage liver disease due to hepatitis C virus. Clin Transpl 11(5 Pt 1):406–411

    CAS  Google Scholar 

  33. Souza ARM (2009) Frequency of major depressive disorder in HTLV-I infected patients. Arq Neuropsiquiatr 67(2A):365–366

    Article  Google Scholar 

  34. Jacka FN, Overland S, Stewart R, Tell GS, Bjelland I, Mykletun A (2009) Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study. Aust N Z J Psychiatry 43(1):45–52

    PubMed  Article  Google Scholar 

  35. Takeda A, Tamano H (2009) Insight into zinc signaling from dietary zinc deficiency. Brain Res Rev 62(1):33–44

    CAS  PubMed  Article  Google Scholar 

  36. Frederickson CJ, Koh J-Y, Bush AI (2005) The neurobiology of zinc in health and disease. Nat Rev Neurosci 6(6):449–462

    CAS  PubMed  Article  Google Scholar 

  37. Yary T, Aazami S (2012) Dietary intake of zinc was inversely associated with depression. Biol Trace Elem Res 145(3):286–290

    CAS  PubMed  Article  Google Scholar 

  38. Ranjbar E, Kasaei MS, Mohammad-Shirazi M, Nasrollahzadeh J, Rashidkhani B, Shams J et al (2013) Effects of zinc supplementation in patients with major depression: a randomized clinical trial. Iranian J Psychiatry 8(2):73

    Google Scholar 

  39. Takeda A, Hirate M, Tamano H, Oku N (2003) Release of glutamate and GABA in the hippocampus under zinc deficiency. J Neurosci Res 72(4):537–542

    CAS  PubMed  Article  Google Scholar 

  40. Rahelić D, Kujundžić M, Romić Ž, Brkić K, Petrovečki M (2006) Serum concentration of zinc, copper, manganese and magnesium in patients with liver cirrhosis. Coll Antropol 30(3):523–528

    PubMed  Google Scholar 

  41. Sharonova IN, Vorobjev VS, Haas HL (1998) High-affinity copper block of GABAA receptor-mediated currents in acutely isolated cerebellar Purkinje cells of the rat. Eur J Neurosci 10(2):522–528

    CAS  PubMed  Article  Google Scholar 

  42. Schlegel-Zawadzka M, Zieba A, Dudek D, Zak-Knapik J, Nowak G (1999) Is serum copper a “trait marker” of unipolar depression? A preliminary clinical study. Pol J Pharmacol 51(6):535–538

    CAS  PubMed  Google Scholar 

  43. Nechifor M (2008) Interactions between magnesium and psychotropic drugs. Magnes Res 21(2):97–100

    CAS  PubMed  Google Scholar 

  44. Chang M-Y, Tseng C-H, Chiou Y-L (2014) The plasma concentration of copper and prevalence of depression were positively correlated in shift nurses. Biol Res Nurs 16(2):175–181

    CAS  PubMed  Article  Google Scholar 

  45. Jacka FN, Maes M, Pasco JA, Williams LJ, Berk M (2012) Nutrient intakes and the common mental disorders in women. J Affect Disord 141(1):79–85

    CAS  PubMed  Article  Google Scholar 

  46. Harris E, Kirk J, Rowsell R, Vitetta L, Sali A, Scholey AB, Pipingas A (2011) The effect of multivitamin supplementation on mood and stress in healthy older men. Hum Psychopharmacol Clin Exp 26(8):560–567

    CAS  Article  Google Scholar 

  47. Li Z, Wang W, Xin X, Song X, Zhang D (2018) Association of total zinc, iron, copper and selenium intakes with depression in the US adults. J Affect Disord 228:68–74

    CAS  PubMed  Article  Google Scholar 

  48. Islam MR, Islam MR, Qusar MS, Islam MS, Kabir MH, Rahman GM et al (2018) Alterations of serum macro-minerals and trace elements are associated with major depressive disorder: a case-control study. BMC Psychiatry 18(1):94

    PubMed  PubMed Central  Article  CAS  Google Scholar 

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Acknowledgments

We thank Prof. Gholam Hossein Hagh Nia for his critical review of this manuscript.

Grant

This study was supported by a grant from Mashhad University of Medical Sciences and was part of two Molecular Medicine PhD thesis (codes: 940247 and 941175).

Author information

Author notes

  1. Susan Darroudi, Samaneh Abolbashari, Najmeh Ahangari, and Maryam Tayefi contributed equally as first authors.

Affiliations

  1. Student Research Committee, Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Susan Darroudi, Samaneh Abolbashari & Najmeh Ahangari

  2. Cardiovascular Research Center, Mashhad University of Medical Science , Mashhad, Iran

    Maryam Tayefi

  3. University International Accreditation, International Office, Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran

    Maryam Tayefi

  4. Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Zahra Khashyarmanesh & Hamideh Moalemzadeh Haghighi

  5. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Parvin Zamani

  6. Clinical Pharmacy Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Amir Hooshang Mohammadpour

  7. Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amir Hooshang Mohammadpour

  8. Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Shima Tavalaei & Majid Ghayour-Mobarhan

  9. Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran

    Habibollah Esmaily

  10. Division of Medical Education, Brighton and Sussex Medical School, Falmer, Brighton, Sussex, BN1 9PH, UK

    Gordon A. Ferns

  11. Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Zahra Meshkat

  12. Preventive Medicine and Public Health Research Center, Iran University of Medical Sciences, Tehran, Iran

    Batool Tayefi

  13. Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, 99199-91766, Iran

    Majid Ghayour-Mobarhan

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  1. Susan Darroudi
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Correspondence to Zahra Meshkat or Majid Ghayour-Mobarhan.

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Darroudi, S., Abolbashari, S., Ahangari, N. et al. Association Between Trace Element Status and Depression in HTLV-1-Infected Patients: a Retrospective Cohort Study. Biol Trace Elem Res 191, 75–80 (2019). https://doi.org/10.1007/s12011-018-1613-6

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  • DOI: https://doi.org/10.1007/s12011-018-1613-6

Keywords

  • HTLV-1
  • Depression
  • Zinc
  • Copper
  • MASHAD study