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The Effects of Magnesium and Vitamin E Co-Supplementation on Hormonal Status and Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome

Biological Trace Element Research volume 191, pages 54–60 (2019)Cite this article

Abstract

Synergistic approach of magnesium and vitamin E may benefit clinical symptoms of patients with polycystic ovary syndrome (PCOS) through improving their metabolic profiles and reducing oxidative stress and inflammation. This study was designed to determine the effects of magnesium and vitamin E co-supplementation on hormonal status and biomarkers of inflammation and oxidative stress in women with PCOS. This randomized, double-blind, placebo-controlled trial was conducted among 60 women with PCOS, aged 18–40 years old. Participants were randomly divided into two groups to take 250 mg/day magnesium plus 400 mg/day vitamin E supplements or placebo (n = 30 each group) for 12 weeks. Fasting blood samples were taken at baseline and after the 12-week intervention to quantify related variables. Magnesium and vitamin E co-supplementation resulted in a significant reduction in hirsutism (β − 0.37; 95% CI, − 0.70, − 0.05; P = 0.02) and serum high-sensitivity C-reactive protein (hs-CRP) (β − 0.67 mg/L; 95% CI, − 1.20, − 0.14; P = 0.01), and a significant increase in plasma nitric oxide (NO) (β 3.40 μmol/L; 95% CI, 1.46, 5.35; P = 0.001) and total antioxidant capacity (TAC) levels (β 66.32 mmol/L; 95% CI, 43.80, 88.84; P < 0.001). Overall, magnesium and vitamin E co-supplementation for 12 weeks may benefit women with PCOS on hirsutism, serum hs-CRP, plasma NO, and TAC levels. Clinical trial registration number http://www.irct.ir: IRCT2017082733941N8

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Funding

The present study was supported by a grant from the Vice-chancellor for Research, AUMS, Arak, and Iran.

Author information

Affiliations

  1. Endocrinology and Metabolism Research Center, Arak University of Medical Sciences, Arak, Iran

    Maryam Shokrpour

  2. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran

    Zatollah Asemi

Authors
  1. Maryam Shokrpour
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  2. Zatollah Asemi
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Contributions

ZA and MS contributed in conception, design, statistical analysis, and drafting of the manuscript. ZA supervised the study.

Corresponding author

Correspondence to Zatollah Asemi.

Ethics declarations

This randomized, double-blinded, placebo-controlled clinical trial is registered in the Iranian clinical trials website (http://www.irct.ir: IRCT2017082733941N8), has followed the Declaration of Helsinki guideline, and informed consent was given by all participants. The study protocol was approved by the Ethics Committee of Arak University of Medical Sciences (AUMS).

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The authors declare that they have no conflict of interest.

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Shokrpour, M., Asemi, Z. The Effects of Magnesium and Vitamin E Co-Supplementation on Hormonal Status and Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome. Biol Trace Elem Res 191, 54–60 (2019). https://doi.org/10.1007/s12011-018-1602-9

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  • DOI: https://doi.org/10.1007/s12011-018-1602-9

Keywords

  • Supplementation
  • Hormonal status
  • Inflammation
  • Oxidative damage